先兆子痫是妊娠并发症的主要原因,影响3-7%的孕妇。子痫前期的病理生理学尚不清楚。根据子痫前期的两阶段模型,胎盘异常和灌注不足(第1阶段)向血流释放因子,导致产妇症状(第二阶段),以全身性炎症和内皮功能障碍为特征。氧化应激在先兆子痫的病理生理学中起着重要作用,并且可能是两者之间的共同点。这篇综述总结了目前对该疾病新的潜在病因的认识,特别关注氧化应激。我们还回顾了引起先兆子痫内皮细胞功能障碍的不同因素。和研究补充抗氧化剂在先兆子痫中的作用的试验。
Preeclampsia is a leading cause of pregnancy complications and affects 3-7% of pregnant women. Pathophysiology of preeclampsia is still unclear. According to the two-stage model of preeclampsia, the abnormal and hypoperfused placenta (stage 1) releases factors to the bloodstream, which are responsible for the maternal symptoms (stage 2), characterised by a systemic inflammation and endothelial dysfunction. Oxidative stress plays an important role in the pathophysiology of the preeclampsia and could be the common denominator between the two. This
review summarizes the current knowledge of a new potential etiology of the disease, with a special focus on oxidative stress. We also
review the different factors that have been proposed to cause endothelial cell dysfunction in preeclampsia, and trials investigating the role of antioxidant supplementation in preeclampsia.