目的:肠道菌群紊乱与多种疾病的病理改变有关。益生菌可以通过调节胃肠道微生态环境来改善症状并发挥临床作用,中国医生通常配发的益生菌产品是活的双歧杆菌的组合,乳酸菌,和粉末/胶囊形式的肠球菌。它含有三株长双歧杆菌,嗜酸乳杆菌,和粪肠球菌-可以协同作用以平衡微生物组,调节免疫力,修复肠道屏障.虽然本产品已在临床实践中被证明是安全有效的,关于其用于治疗消化系统疾病的不确定性仍然存在。迄今为止,本产品尚无指导临床实践的参考标准,也没有相关专家共识,在中国。
方法:在文献检索之后,根据建议评估的等级对证据进行分级和分类,发展,一个由52名专家组成的小组获得了评估系统和共识。
结果:已经形成专家共识,双歧杆菌联合活菌的临床应用,乳酸菌,和肠球菌在各种消化系统疾病中,为其临床使用提供参考。
结论:双歧杆菌三联活菌粉/胶囊可能有好处,通过调节肠道微生态的平衡。它可用于各种消化系统疾病的治疗和预防,具有良好的总体安全性;需要进一步的研究以确认其在其他情况下的应用。本共识中的建议将根据未来的研究和临床实践得到确认或完善。
OBJECTIVE: Disturbance of gut microbiota is associated with pathological change in multiple diseases. Probiotics can improve symptoms and exert clinical effects via regulation of gastrointestinal microecological environments, and a probiotic product commonly dispensed by Chinese physicians is a combination of live Bifidobacterium, Lactobacillus, and Enterococcus in powder/capsule form. It contains three strains-of Bifidobacterium longum, Lactobacillus acidophilus, and Enterococcus faecalis-which can act synergistically to balance the microbiome, regulate immunity, and repair the gut barrier. Although this product has been proven safe and effective in clinical practice, uncertainty remains regarding its use to treat digestive system diseases. To date, there have been no reference standards to guide clinical practice and no relevant expert
consensus on this product, in China.
METHODS: Following a literature search, evidence was graded and classified according to the grading of recommendations assessment, development, and evaluation (GRADE) system and
consensus was secured from a panel of 52 experts.
RESULTS: An expert
consensus has been formed, on the clinical application of live combined Bifidobacterium, Lactobacillus, and Enterococcus in various digestive system diseases, to provide reference for its clinical use.
CONCLUSIONS: Bifidobacterium triple viable powder/capsule may offer benefits, by regulating the balance of intestinal microecology. It can be used for the treatment and prevention of various digestive system diseases with good overall safety; further research is needed to confirm its application in other contexts. The recommendations in this
consensus will be confirmed or refined in light of future research and clinical practice.