Postoperative period

术后期间
  • 文章类型: Journal Article
    探讨精细化护理策略对术后生活质量的影响,疼痛程度,心理状况,以及其他颈椎病患者的康复训练。本研究为回顾性研究,并选取2022年4月至2023年6月我院收治的500例颈椎病患者作为研究对象.根据是否接受个性化重症监护分为对照组(250例)和实验组(250例)。对照组给予标准护理,而实验组给予个性化,优质护理。精细化护理策略包括个性化康复训练计划,心理支持,营养咨询,和疼痛管理。疼痛程度等指标,颈椎功能,生活质量,并发症统计,并对2种护理方法的临床疗效进行评价。在疼痛评估中,实验组和对照组的疼痛评分分别为(1.98±0.84)和(5.78±0.63),分别,护理干预后。与护理前相比,实验组患者的疼痛减轻非常显着(P<0.05)。医疗保健开始六个月后,实验组和对照组的颈椎功能评分分别为(93.36±4.74)和(82.68±5.42),分别。此外,实验组的颈椎功能恢复显著。与对照组相比,实验组出现并发症的可能性较低。此外,实验组的生活质量明显高于对照组(P<0.05)。实验组患者的改善时间和愈合时间明显短于对照组。在护理满意度方面,实验组的满意率为87.57%,明显高于对照组(P<0.05)。精细化护理策略显著提高了患者功能恢复的速度和质量。此外,在颈椎病术后治疗过程中实施个性化、综合性的护理技术,使患者的生活质量和对治疗过程的满意度得到显著提高。
    To investigate the effects of refined nursing strategies on postoperative quality of life, pain level, psychological condition, and other rehabilitation training of patients with cervical spondylosis. This study is a retrospective study, and 500 patients with cervical spondylosis admitted to our hospital from April 2022 to June 2023 were selected as the study objects. They were divided into a control group (250 cases) and an experimental group (250 cases) according to whether they received personalized intensive care. The control group received standard nursing care, while the experimental group was given personalized, high-quality nursing care. The refined nursing strategy comprises individualized rehabilitation training plans, psychological support, nutritional counseling, and pain management. Indicators such as pain level, cervical spine function, quality of life, complication statistics, and nursing satisfaction were employed to evaluate the clinical efficacy of 2 nursing methods. In the pain assessment, patients in the experimental and control groups had pain scores of (1.98 ± 0.84) and (5.78 ± 0.63), respectively, after the nursing intervention. The reduction in pain for patients in the experimental group was highly significant (P < .05) compared to pre-nursing care. Six months after the commencement of healthcare, the cervical spine function scores of the experimental and control groups were (93.36 ± 4.74) and (82.68 ± 5.42), respectively. Moreover, the cervical spine function recovery of the experimental group was deemed significant. The experimental group exhibited a lower probability of complications compared to the control group. Additionally, the quality of life was significantly higher in the experimental group than in the control group (P < .05). Improvement time and healing time were significantly shorter in the patients of the experimental group in comparison to the control group. In terms of nursing satisfaction, the experimental group had a significantly higher satisfaction rate of 87.57% than the control group (P < .05). The refined nursing strategy significantly improved the speed and quality of patients\' functional recovery. Additionally, the implementation of personalized and comprehensive nursing techniques during postoperative treatment for cervical spondylosis resulted in a significant improvement in patient\'s quality of life and satisfaction with the treatment process.
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  • 文章类型: English Abstract
    One critical aspect of managing pediatric glaucoma is the compliance of parents, who are responsible for the care of their children. Achieving consensus between specialists and parents on the organization of comprehensive care is essential for the effective rehabilitation of young patients with glaucoma.
    OBJECTIVE: This study assesses the level of parental compliance with rehabilitation measures and attempts to identify the factors affecting it during the rehabilitation period of children after surgical treatment of congenital glaucoma.
    METHODS: The study was conducted through a survey involving 62 parents of children who underwent surgical treatment for glaucoma at the ophthalmology department of the Tashkent Pediatric Medical Institute. Parents were provided with a link to the online survey after giving their consent. The questionnaire consisted of eight questions with multiple-choice answers.
    RESULTS: Analysis of the answers showed the following trends: the majority of parents had either a secondary or vocational education (59.7%); most parents lived in rural areas (64.5%); a significant portion had partial or no knowledge about the course and outcomes of glaucoma (51.6%); unreliable sources for information (45.2%); irregular adherence to the doctor\'s recommendations (29%); significant difficulties in following the prescribed recommendations (64.5%).
    CONCLUSIONS: It was found that the level of parental compliance with rehabilitation measures is low in a significant portion of families (37.2%) with children who underwent surgery for glaucoma. The main factors contributing to poor parental compliance include living in rural areas, insufficient knowledge about the disease, lack of strict adherence to medical recommendations, and various difficulties in implementing the prescribed recommendations (p<0.05).
    Актуальным вопросом в лечении детской глаукомы является комплаентность родителей, осуществляющих уход за детьми, так как достижение согласия между специалистами и родителями по вопросам организации комплексной помощи ребенку является одним из условий достижения эффективной реабилитации маленьких пациентов с глаукомой.
    UNASSIGNED: Оценить уровень комплаентности родителей к проводимым реабилитационным мероприятиям и выделить факторы, влияющие на нее в период реабилитации детей после хирургического лечения врожденной глаукомы.
    UNASSIGNED: Проведенное нами исследование осуществлялось с помощью анкетирования, в котором участвовали 62 родителя детей, перенесших хирургическое лечение по поводу глаукомы в глазном отделении клиники Ташкентского медицинского педиатрического института. Ссылка на анкетирование предоставлялась родителям, осуществляющим уход за детьми с глаукомой, после получения их согласия. Был составлен опросник, включающий восемь вопросов с вариантами ответов на каждый вопрос.
    UNASSIGNED: Анализ ответов на вопросы показал, что в большинстве случаев отмечалось: среднее и среднее специальное образование родителей (59,7%); превалирование родителей, проживающих в сельской местности (64,5% случаев); частичная информированность родителей о течении и исходах заболевания «глаукома» или отсутствие информированности (51,6%); недостоверные источники получения информации (45,2%); нерегулярное выполнение рекомендаций лечащего врача (29%); наличие трудностей при выполнении назначенных рекомендаций (64,5%).
    UNASSIGNED: Было установлено, что во многих семьях (37,2%), имеющих детей с оперированной глаукомой, уровень родительской комплаентности к проводимым реабилитационным мероприятиям является низким. К основным значимым факторам, влияющим на низкую комплаентность родителей, можно отнести: проживание в сельской местности, недостаточную информированность о заболевании, отсутствие строгого следования рекомендациям врача, наличие различных трудностей при выполнении рекомендаций, назначенных лечащим врачом (p<0,05).
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  • 文章类型: Journal Article
    比较具有三种不同地形图的偏心圆锥角膜患者植入KERATACx环段(ImperialMedicalTechnologiesEuropeGmbH)后的术后结果。
    这项回顾性队列研究是在Maadi眼科亚专科中心进行的,开罗,埃及。该研究包括植入KERATACx环节段的圆锥角膜患者。使用SiriusCSO地形图师(CSOItalia)根据地形圆锥角膜模式将三组分开:I型扩张,其中圆锥与角膜平轴重合,II型扩张,其中锥体既不与陡峭轴重合,也不与平坦轴重合,并且位于两个轴之间,和II型扩张为视锥与角膜陡轴重合。比较三组患者术前和术后的视觉和地形结果。
    本研究纳入92例患者的92只眼,平均±标准差随访16.9±9.2个月。患者的医疗记录显示,III型扩张组的夜视投诉和光线周围的光晕最多(31.25%)。对于III型扩张组,四个地形指数和一个视觉参数在术前和术后数据之间没有统计学上的显着差异(在2毫米和4毫米直径,慧差,高阶像差,和未校正的远距视力),与I型和II型扩张组相反,这表明所有评估参数都有显著改善。
    扩张的III型形态模式是最不可能从KERATACx环段植入中受益的。[JRefractSurg.2024;40(9):e625-e634。].
    UNASSIGNED: To compare the postoperative outcomes following implantation of KERATACx ring segments (Imperial Medical Technologies Europe GmbH) in patients having eccentric keratoconus with three different topographic patterns.
    UNASSIGNED: This retrospective cohort study was conducted at Maadi Eye Subspeciality Center, Cairo, Egypt. The study included patients with keratoconus who had implantation of KERATACx ring segments. Three groups were segregated based on topographic keratoconus patterns using the Sirius CSO Topographer (CSO Italia): type I ectasia where the cone coincides with the corneal flat axis, type II ectasia in which the cone coincides with neither the steep nor the flat axis and lies between the two axes, and type II ectasia for cones coinciding with the corneal steep axis. The visual and topographic outcomes were compared preoperatively and postoperatively for the three enrolled groups.
    UNASSIGNED: This study enrolled 92 eyes of 92 patients and had a mean ± standard deviation follow-up of 16.9 ± 9.2 months. The patients\' medical records revealed that night vision complaints and halos around the light were experienced the most by the type III ectasia group (31.25%). For the type III ectasia group, four topographic indices and one visual parameter did not show statistically significant differences between the preoperative and postoperative data (inferior-superior difference at 2- and 4-mm diameter, coma aberration, higher order aberrations, and uncorrected distance visual acuity), contrary to the type I and II ectasia groups, which showed significant improvements in all evaluated parameters.
    UNASSIGNED: The type III morphological pattern of ectasia is the least likely to benefit from KERATACx ring segments implantation. [J Refract Surg. 2024;40(9):e625-e634.].
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  • 文章类型: Journal Article
    背景:麻醉前的血压读数通常会影响推迟或取消择期手术的决定。然而,这些特定血压值的含义,尤其是它们与基线的比较,术后30天院内死亡率仍未充分发现.这项研究旨在检查手术前一天在病房评估的基线血压之间的差异的影响。麻醉前观察到的血压,术后死亡风险。
    方法:该研究涵盖了在首尔三级护理中心进行非心脏手术的60,534名成年人,韩国。基线血压计算为手术前24小时内获取的血压读数的平均值。麻醉前血压是在施用麻醉之前测量的血压。我们将住院30天死亡率作为主要结果。
    结果:我们的研究表明,较低的麻醉前收缩压或平均血压偏离基线20mmHg或更多,会显著增加30天死亡的风险。这种关联在有高血压病史的个体和65岁及以上的个体中尤为明显。较高的麻醉前血压与30天死亡率的风险增加无关。
    结论:我们发现,与基线相比,较低的麻醉前血压会显著增加术后30天死亡风险,而较高的麻醉前血压没有。我们的研究强调在评估手术风险和结果时考虑基线和麻醉前血压变化的重要性。
    BACKGROUND: Blood pressure readings taken before anesthesia often influence the decision to delay or cancel elective surgeries. However, the implications of these specific blood pressure values, especially how they compare to baseline, on postoperative in-hospital 30-day mortality remain underexplored. This research aimed to examine the effect of discrepancies between the baseline blood pressure evaluated in the ward a day before surgery, and the blood pressure observed just before the administration of anesthesia, on the postoperative mortality risks.
    METHODS: The study encompassed 60,534 adults scheduled for non-cardiac surgeries at a tertiary care center in Seoul, Korea. Baseline blood pressure was calculated as the mean of the blood pressure readings taken within 24 hours prior to surgery. The preanesthetic blood pressure was the blood pressure measured right before the administration of anesthesia. We focused on in-hospital 30-day mortality as the primary outcome.
    RESULTS: Our research revealed that a lower preanesthetic systolic or mean blood pressure that deviates by 20 mmHg or more from baseline significantly increased the risk of 30-day mortality. This association was particularly pronounced in individuals with a history of hypertension and those aged 65 and above. Higher preanesthetic blood pressure was not significantly associated with an increased risk of 30-day mortality.
    CONCLUSIONS: We found that a lower preanesthetic blood pressure compared to baseline significantly increased the 30-day postoperative mortality risk, whereas a higher preanesthetic blood pressure did not. Our study emphasizes the critical importance of accounting for variations in both baseline and preanesthetic blood pressure when assessing surgical risks and outcomes.
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  • 文章类型: Journal Article
    机器人手术提供精确控制,允许最佳解剖和切割组织,同时最大限度地减少出血。然而,经常记录机器人辅助前列腺癌根治术(RARP)后血红蛋白(Hb)显著下降.当前的研究旨在检查接受RARP的前列腺癌(PCa)患者术后Hb下降及其预测因素。从我们三级护理中心前瞻性维护的数据库中,所有在2022年1月至2023年1月期间接受RARP的PCa患者均被确认.对于每个病人来说,基线,麻醉学,和手术特点,以及手术前后的血液样本,被收集。多变量线性和逻辑回归模型拟合,以研究术前和术后一天(POD)之间线性Hb下降或Hb下降≥2g/dl的潜在预测因素。在RARP之后。总的来说,110例RARP患者入组。考虑到Hb,术前中位数和POD1值分别为14.6和12.7g/dl(Δ=1.9,p<0.001);POD2和POD3之间无统计学差异(12.4vs12.5g/dl,Δ=0.1,p=0.1)。经过多变量分析,年龄,BMI,前列腺体积,保留神经的方法,麻醉时间,术中液体,术中失血,术中利尿无统计学意义(P均>0.05)。当前的前瞻性研究表明,直到POD1,Hb才有统计学意义的下降。之后,记录到Hb值的快速稳定。这种减少与术前和术中变量无关。这些观察结果可能在术后住院患者RARP管理中起重要作用,在大批量和小批量的中心。
    Robotic surgery provides precise control, allowing for optimal dissection and cutting of tissues while minimizing bleeding. However, a significant drop in hemoglobin (Hb) after robot-assisted radical prostatectomy (RARP) is often recorded. The current study aimed to examine the postoperative Hb drop and its predictive factors in prostate cancer (PCa) patients who underwent RARP. From our tertiary care center\'s prospectively maintained database, all PCa patients who underwent RARP from January 2022 to January 2023 were identified. For each patient, baseline, anesthesiologic, and surgical characteristics, as well as blood samples before and after surgery, were collected. Multivariable linear and logistic regression models were fitted to investigate potential predictive factors of linear Hb drop or Hb drop ≥ 2 g/dl between preoperative and postoperative day (POD) one, after RARP. Overall, 110 RARP patients were enrolled. Considering the Hb, the median preoperative and POD1 values were 14.6 and 12.7 g/dl respectively (∆ = 1.9, p < 0.001); between POD2 and POD3, no statistically significant difference was recorded (12.4 vs 12.5 g/dl, ∆ = 0.1, p = 0.1). After multivariable analyses, age, BMI, prostate volume, nerve-sparing approach, anesthesia time, intraoperative fluids, intraoperative blood loss, and intraoperative diuresis did not show a statistically significant predictive value (all p > 0.05). The current prospective study showed a statistically significant Hb drop until POD1. After that, a quick stabilization of the Hb value was recorded. This reduction was not correlated with pre- and intraoperative variables. These observations might play an important role in postoperative inpatient RARP management, in both large and low-volume centers.
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  • 文章类型: Case Reports
    心脏外科手术会引起一系列人体生理障碍。全身血液动力学变量的校正通常在改善微循环灌注和向组织输送氧气方面无效。我们介绍了一名52岁男性接受二尖瓣置换术(金属瓣膜)和主动脉下膜切除术的情况。术前和术后早期使用手持式CytoCam相机评估舌下微循环密度和灌注。在这种情况下,尽管与术前评估相比,微循环参数有实际改善,但全身血液动力学变量受损,可能是由于结构性心脏缺陷的矫正。
    Cardiac surgery causes a series of disturbances in human physiology. The correction of systemic hemodynamic variables is frequently ineffective in improving microcirculatory perfusion and delivering oxygen to the tissues. We present the case of a 52-year-old male submitted to mitral valve replacement (metallic valve) and subaortic membrane resection. Sublingual microcirculatory density and perfusion were evaluated using a handheld CytoCam camera before surgery and in the early postoperative period. In this case, systemic hemodynamic variables were compromised despite an actual improvement in the microcirculatory parameters in comparison to the preoperative evaluation, possibly due to the correction of the structural cardiac defects.
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  • 文章类型: Journal Article
    手术部位感染与术后住院时间延长有关。我们探讨了与埃塞俄比亚一家基层农村医院的外科病房患者术后住院时间延长相关的因素,没有用于手术部位感染的微生物确认的实验室设施。
    在2017年6月22日至2018年7月19日期间,对≥18岁接受择期或急诊手术的患者进行了一项观察性研究。数据来自纸质医疗记录和患者访谈。主要结果是术后住院时间。数据采用Stata软件进行多元线性回归分析,版本13.
    共纳入75名患者,通过访谈从这些患者中的14名获得了社会人口统计学数据,44例患者具有完整的结局和协变量数据,并纳入回归分析.术前住院时间的中位数为3.0(四分位距2.0)天。术后住院时间延长3.8天(95%置信区间(CI)1.05-6.55;p=0.008),4.7天(95%CI1.64-7.66;p=0.004),和5.9天(95%CI2.70-9.02;p=0.001),对于35-54岁的患者,分别为55-64岁和65岁以上,与18-34岁的患者相比。与未接受术前抗生素治疗的患者相比,接受术前抗生素治疗的患者的停留时间延长了5.3天(95%CI1.67-8.87;p=0.005)。
    年龄和术前抗生素使用不当会增加术后住院时间的风险。感染预防方案,包括员工培训,手术部位感染的监测对于改善医院预后至关重要.
    UNASSIGNED: surgical site infection is associated with longer postoperative hospital stays. We explored factors associated with longer postoperative hospital stays among patients in the surgical ward of a primary rural hospital in Ethiopia, where laboratory facilities for microbiological confirmation of surgical site infections were not available.
    UNASSIGNED: an observational study was performed for patients ≥ 18 years of age who underwent elective or emergency surgery from 22nd June 2017 to 19th July 2018. Data were taken from paper-based medical records and patient interviews. The primary outcome was postoperative length of hospital stay. Data were analyzed by multivariable linear regression using Stata software, version 13.
    UNASSIGNED: seventy-five patients were enrolled, sociodemographic data was obtained from 14 of these patients by interview, and 44 patients had complete outcome and covariate data and were included in regression analysis. Median length of preoperative hospital stay was 3.0 (interquartile range 2.0) days. Postoperative length of hospital stay was longer by 3.8 days (95% confidence interval (CI) 1.05-6.55; p=0.008), 4.7 days (95% CI 1.64-7.66; p=0.004), and 5.9 days (95% CI 2.70-9.02; p=0.001), for patients 35-54 years, 55-64 years and the 65+ years respectively, compared to patients who were 18-34 years of age. Patients who received preoperative antibiotics stayed 5.3 days longer (95% CI 1.67-8.87; p=0.005) compared to those who were not given preoperative antibiotics.
    UNASSIGNED: age and improper use of preoperative antibiotics compound the risk for postoperative length of stay. Infection prevention protocols, including staff training, and surveillance for surgical site infections are critical for improving hospital outcomes.
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  • 文章类型: Journal Article
    目的:本研究旨在探讨超声造影(CEUS)能否用于揭示大鼠模型浅表皮瓣术后早期的血供状况。
    方法:在同一只大鼠的左右背部分别制备一个活瓣和一个缺血随机型皮瓣,数量为40。术后12h和7天内进行CEUS检查,并且两个皮瓣的基部和末端的微血管血容量(BV)的定量测量使用声学强度与健康皮肤的比率来表示。
    结果:术后12小时内,缺血末端的BV值小于缺血基础和存活末端的BV值(p<0.001),而缺血碱基和活基之间或活基和活端之间没有差异。手术后7天提供相同的结果。
    结论:可以通过CEUS定量评估该大鼠模型中诸如随机模式皮瓣的浅表组织的微循环。它能灵敏、准确地揭示术后早期组织灌注的客观状态。
    OBJECTIVE: This study aims to investigate whether contrast-enhanced ultrasound (CEUS) could be used to reveal the status of blood supply of the superficial flap of rat model in the early postoperative stage.
    METHODS: One viable and one ischemic random-pattern flap were prepared on the left and right back of the same rat respectively with a number of 40. CEUS examinations were applied within 12 h and 7 days postoperatively, and the quantitative measurements of microvascular blood volume (BV) of the base and the end of both flaps were expressed using acoustic intensity as a ratio to that of the healthy skin.
    RESULTS: Within 12 h post operation, there was a smaller BV value of the ischemic ends than that of both the ischemic bases and viable ends (p < 0.001), while no difference was indicated between ischemic bases and viable bases or between viable bases and viable ends. The same result was provided 7 days post operation.
    CONCLUSIONS: Microcirculation of superficial tissues such as random-pattern flaps in this rat model can be assessed quantitatively by CEUS. It could sensitively and accurately reveal the objective status of tissue perfusion in the early postoperative stage.
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  • 文章类型: Journal Article
    背景:讨论了使用体外循环(CPB)的冠状动脉手术中泵流量类型对灌注的影响。我们旨在通过神经认知功能测试评估泵流量类型对认知功能的影响。
    方法:将2020年11月至2021年7月接受孤立性冠状动脉搭桥手术的100例患者分为两组。根据泵流型脉动(组1)和非脉动(组2)形成组。术前对两组患者进行时钟绘制测试(CDT)和标准化迷你心理测试(SMMT),在术前第一天,在出院前一天。将神经认知效果与所有随访参数进行比较。
    结果:两组之间在人口统计学数据和手术前进行的神经认知测试方面没有差异。术后第1天的SMMT(I组:27.64±1.05;II组:24.44±1.64;P=0.001)和CDT(I组:5.4±0.54;II组:4.66±0.52;P=0.001),出院前一天的SMMT(I组:27.92±1.16;II组:24.66±1.22;P=0.001)和CDT(I组:5计算为.66±0.48;II组:5.44±0.5;P=0.001)。非搏动组的重症监护和住院时间较高。
    结论:我们认为使用CPB的冠状动脉搭桥手术中使用的泵流量类型在神经认知功能方面是有效的,并且搏动流量对此问题做出了积极贡献。
    BACKGROUND: The effect of pump flow type on perfusion in coronary surgery using cardiopulmonary bypass (CPB) is discussed. We aimed to evaluate the effect of pump flow type on cognitive functions with neurocognitive function tests.
    METHODS: One hundred patients who underwent isolated coronary artery bypass surgery between November 2020 and July 2021 were divided into two equa groups. Groups were formed according to pump flow type pulsatile (Group 1) and non-pulsatile (Group 2). Clock drawing test (CDT) and standardized mini mental test (SMMT) were performed on the patients in both groups in the preoperative period, on the 1st preoperative day, and on the day before discharge. Neurocognitive effects were compared with all follow-up parameters.
    RESULTS: There was no difference between the groups in terms of demographic data and in terms of neurocognitive tests performed before the operation. SMMT on postoperative day 1 (Group I: 27.64 ± 1.05; Group II: 24.44 ± 1.64; P=0.001) and CDT (Group I: 5.4 ± 0.54; Group II: 4 .66 ± 0.52; P=0.001), and SMMT on the day before discharge (Group I: 27.92 ± 1.16; Group II: 24.66 ± 1.22; P=0.001) and CDT (Group I: 5 It was calculated as .66 ± 0.48; Group II: 5.44 ± 0.5; P=0.001). The duration of intensive care and hospitalization were higher in the non-pulsatile group.
    CONCLUSIONS: We think that the type of pump flow used in coronary artery bypass surgery using CPB is effective in terms of neurocognitive functions and that pulsatile flow makes positive contributions to this issue.
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  • 文章类型: Journal Article
    目的:目的:确定腹膜炎患者开发的复杂治疗方法对疾病过程中非特异性反应性体液因子动力学的影响。
    方法:材料和方法:该研究包括124例毒性和终末期腹膜炎患者,他们被分成3组。组I(主要)包括39名患者,其复杂治疗包括细胞色素C。组II(主要)包括41名患者,其复杂治疗包括细胞色素C和含有左卡尼汀和盐酸精氨酸的溶液。对照组包括44例未接受指定药物的患者。患者接受了纤维连接蛋白水平的测定,铜蓝蛋白,在疾病过程中血清中的降钙素原。
    结果:结果:在I和II主组患者中,使用拟议的治疗方法有助于优化急性期蛋白的产生:研究期间降钙素原的产生减少,铜蓝蛋白和纤连蛋白生产的优化,尤其是在II主组。在对照组的患者中,失代偿产生的体液炎症因子测定,与纤连蛋白产生的显着增加有关,铜蓝蛋白含量降低,以及在整个时期降钙素原的增加。
    结论:结论:在播散性腹膜炎患者的复杂治疗中使用细胞色素C和含有左卡尼汀和盐酸精氨酸的溶液有助于优化急性期蛋白的产生,这导致炎症减少,并在亚补偿水平上保留非特异性体液活性因子。
    OBJECTIVE: Aim: To determine the effect of the developed complex treatment of patients with peritonitis on the dynamics of humoral factors of nonspecific reactivity in the course of the disease.
    METHODS: Materials and Methods: The study included 124 patients with toxic and terminal stages of peritonitis, who were divided into 3 groups. Group I (main) included 39 patients whose complex treatment included cytochrome C. Group II (main) included 41 patients whose complex treatment included cytochrome C and a solution containing levocarnitine and arginine hydrochloride. The comparison group comprised 44 patients who did not receive the specified drugs. The patients underwent determination of the levels of fibronectin, ceruloplasmin, and procalcitonin in the serum during the course of the disease.
    RESULTS: Results: In patients of the I and II main groups, the use of the proposed treatment contributed to the optimization of the production of acute phase proteins: a decrease in procalcitonin production during the study, optimization of ceruloplasmin and fibronectin production, especially in the II main group. In patients of the comparison group, decompensation in the production of humoral inflammatory factors was determined, associated with a significant increase in fibronectin production, a decrease in ceruloplasmin content, and an increase in procalcitonin throughout the entire period.
    CONCLUSIONS: Conclusions: The use of cytochrome C and a solution containing levocarnitine and arginine hydrochloride in the complex treatment of patients with disseminated peritonitis helps to optimize the production of acute phase proteins, which leads to a decrease in inflammation and the preservation of factors of nonspecific humoral activity at a subcompensated level.
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