背景:最近的研究表明,非恶性疟疾的流行,包括疟原虫和卵疟原虫。,正在增加,感染个体的一些并发症。这篇综述的目的是更好地了解疟疾流行率和疟疾由疟原虫和卵卵圆虫引起的疾病负担。
方法:使用系统审查和荟萃分析(PRISMA)指南的首选报告项目和JoannaBriggs研究所的患病率研究评估工具来选择和评估研究。分别。六个数据库:PubMed,WHOLIS,威利图书馆,ScienceDirect,WebofScience和GoogleScholar用于筛选2000年1月至2020年12月期间发表的文章。疟疾疟原虫和卵卵圆虫的合并患病率估计。使用随机效应模型进行分析,并通过亚组分析和荟萃回归评估异质性的可能来源。
结果:在筛选的3297项研究中,仅纳入113项研究;其中51.33%来自非洲地区.疟原虫和卵卵圆虫。合并患病率分别为2.01%(95%CI1.31-2.85%)和0.77%(95%CI0.50-1.10%),非洲区域患病率最高。疟原虫在成年人中分布均匀(2.13%),儿童(2.90%)和孕妇(2.77%)(p=0.862),而P.Ovalespp.孕妇(2.90%)比≤15岁的儿童(0.97%)和>15岁的患者(0.39%)更普遍(p=0.021)。在这次审查中,数据分析显示,疟原虫和卵卵圆虫。在过去的20年里有所下降,但并不重要,这些物种更常见于其他疟原虫的共感染。在有症状和无症状的患者中,没有观察到有症状和无症状的患者的患病率差异。
结论:我们的分析表明,对疟原虫和卵圆虫的全球负担的了解。对消除疟疾方案非常重要,应特别重视监测这些非恶性疟原虫物种传播的改进工具,以应对未来增加的感染。
BACKGROUND: Recent studies indicate that the prevalence of non-falciparum malaria, including Plasmodium malariae and Plasmodium ovale spp., is increasing, with some complications in infected individuals. The aim of this
review is to provide a better understanding of the malaria prevalence and disease burden due to P. malariae and P. ovale spp.
METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Joanna Briggs Institute prevalence study assessment tool were used to select and evaluate the studies, respectively. Six databases: PubMed, WHOLIS, Wiley Library, ScienceDirect, Web of Science and Google Scholar were used to screen articles published during the period January 2000-December 2020. The pooled prevalence estimates for P. malariae and P. ovale spp. were analysed using a random-effects model and the possible sources of heterogeneity were evaluated through subgroup analysis and meta-regression.
RESULTS: Out of the 3297 studies screened, only 113 studies were included; among which 51.33% were from the African Region. The P. malariae and P. ovale spp. pooled prevalence were 2.01% (95% CI 1.31-2.85%) and 0.77% (95% CI 0.50-1.10%) respectively, with the highest prevalence in the African Region. P. malariae was equally distributed among adults (2.13%), children (2.90%) and pregnant women (2.77%) (p = 0.862), whereas P. ovale spp. was more prevalent in pregnant women (2.90%) than in children ≤ 15 years (0.97%) and in patients > 15 years old (0.39%) (p = 0.021). In this
review, data analysis revealed that P. malariae and P. ovale spp. have decreased in the last 20 years, but not significantly, and these species were more commonly present with other Plasmodium species as co-infections. No difference in prevalence between symptomatic and asymptomatic patients was observed for either P. malariae or P. ovale spp.
CONCLUSIONS: Our analysis suggests that knowledge of the worldwide burden of P. malariae and P. ovale spp. is very important for malaria elimination programmes and a particular focus towards improved tools for monitoring transmission for these non-falciparum species should be stressed upon to deal with increased infections in the future.