PDF(Pubmed)
Abstract：
Malaria is a life-threatening parasitic disease caused by various forms of the protozoa Plasmodium and is transmitted by the female Anopheles mosquito. The parasitic infection is endemic in 90 countries, with approximately 500 million cases reported annually and an estimated annual mortality of 1.5-2.7 million individuals. Historically, the use of antimalarial drugs has been promising for the chemoprophylaxis and treatment of malaria, mitigating the annual mortality rate. Notably, these antimalarial drugs have been associated with various adverse effects, including gastrointestinal upset and headaches. However, the adverse cutaneous manifestations these antimalarial drugs may lead to are poorly documented and understood. We aim to describe the lesser-studied adverse cutaneous pathologies of malaria treatment to better educate physicians on the proper treatment of their patients. Our narrative review describes the skin manifestations associated with specific antimalarial treatments and their associated prognoses and treatments. The cutaneous pathologies discussed include aquagenic pruritus (AP), palmoplantar exfoliation, Steven-Johnson syndrome, toxic epidermal necrolysis, cutaneous vasculitis, psoriasis, ecchymosis, and tropical lichenoid dermatitis. Further studies and vigilant documentation of the cutaneous adverse events of antimalarial drugs need to be performed and emphasized to prevent potential life-threatening adverse outcomes.
摘要：
疟疾是由各种形式的原生动物疟原虫引起的威胁生命的寄生虫病，并由雌性按蚊传播。寄生虫感染在90个国家流行，每年报告约5亿例病例，估计每年死亡150万至270万人。历史上,抗疟药物的使用有望用于疟疾的化学预防和治疗，降低年死亡率。值得注意的是,这些抗疟药与各种不良反应有关，包括肠胃不适和头痛.然而,这些抗疟药可能导致的不良皮肤表现缺乏文献记载和了解.我们的目的是描述研究较少的疟疾治疗的不良皮肤病理学，以更好地教育医生对患者的正确治疗。我们的叙述性综述描述了与特定抗疟药治疗相关的皮肤表现及其相关的预后和治疗。讨论的皮肤病理包括水性瘙痒（AP），掌plant剥脱，Steven-Johnson综合征,中毒性表皮坏死松解症，皮肤血管炎,牛皮癣,瘀斑,热带苔藓样皮炎.需要对抗疟药的皮肤不良事件进行进一步的研究和警惕的记录，以防止潜在的危及生命的不良结果。
