自由生活的变形虫引起的感染构成了重大的公共卫生威胁,这是由于免疫功能低下的宿主群体不断增加,同时诊断延迟。治疗困难,和高病死率。由棘阿米巴引起的鼻咽感染很少见,最佳治疗方法尚不完善。我们报告了一例慢性淋巴细胞白血病患者的棘阿米巴鼻鼻窦炎,该患者表现为头痛和慢性鼻窦炎,对多个疗程的抗生素均无效。通过对窦组织进行广泛的聚合酶链反应测试,可以诊断出棘阿米巴鼻鼻窦炎。病人对治疗反应良好,其中包括手术清创术,停止免疫抑制剂,和由米替福辛组成的三药方案,氟康唑,还有磺胺嘧啶.
Infections caused by free-living amoebae pose a significant public health threat owing to growing populations of immunocompromised hosts combined with diagnostic delays, treatment difficulties, and high
case fatality rates. Nasopharyngeal infections caused by Acanthamoeba are rare and the optimal treatment is not well established. We report a
case of Acanthamoeba rhinosinusitis in a patient with chronic lymphocytic leukemia who presented with headaches and chronic rhinosinusitis refractory to multiple courses of antibiotics. A diagnosis of Acanthamoeba rhinosinusitis was established through broad-range polymerase chain reaction testing on sinus tissue. The patient had a favorable response to treatment, which included surgical debridement, cessation of immunosuppressants, and a three-drug regimen consisting of miltefosine, fluconazole, and sulfadiazine.