磷酸肌醇在调节许多细胞功能中起着至关重要的作用，如肌动蛋白动力学，信令,细胞内贩运，膜动力学，和细胞-基质粘附。该过程的中心是磷脂酰肌醇双磷酸(PIP2)。膜中PIP2的水平通过磷酸肌醇定向激酶和磷酸酶的活性迅速改变，它与几十种不同的细胞内蛋白质结合。尽管过去30年有大量文献致力于了解细胞中PIP2的调控，关于它的细胞功能还有很多有待了解。在这次审查中,我们关注过去和最近关于不同分子机制的令人兴奋的结果,这些机制通过特定蛋白与PIP2的结合或通过稳定不同细胞区室中的磷酸肌醇池来调节细胞功能.此外，这篇综述总结了最近的发现，这些发现涉及许多疾病中PIP2的失调。
Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell-matrix adhesion. Central to this process is phosphatidylinositol bisphosphate (PIP2). The levels of PIP2 in the membrane are rapidly altered by the activity of phosphoinositide-directed kinases and phosphatases, and it binds to dozens of different intracellular proteins. Despite the vast literature dedicated to understanding the regulation of PIP2 in cells over past 30 years, much remains to be learned about its cellular functions. In this
review, we focus on past and recent exciting results on different molecular mechanisms that regulate cellular functions by binding of specific proteins to PIP2 or by stabilizing phosphoinositide pools in different cellular compartments. Moreover, this
review summarizes recent findings that implicate dysregulation of PIP2 in many diseases.
PDF(Sci-hub)