■伤口已成为全球范围内的主要健康挑战,呈现显著的人文和经济负担,如残疾和死亡。每年,全世界约有1400万人遭受创伤,其中80%发生在乌干达等发展中国家。在乌干达,除了许多每天发生的伤口,大约10%的外科手术成为脓毒性伤口,因此导致发病率和死亡率增加。因此,一些种族医学研究已经确定了在乌干达不同地区用于伤口治疗的植物,并且已经报道了一些植物的伤口愈合活性。然而,目前,这些信息在很大程度上是分开的,没有包含乌干达用于伤口愈合的植物的种族医学和药理学信息的全面存储库,从而阻碍了适当的评估。因此,这篇综述集中在广泛探索乌干达用于治疗皮肤伤口的植物,以及相关的种族医学信息及其全球报告的药理潜力。
■电子数据库,包括谷歌学者,PubMed,和ScienceDirect使用关键术语搜索英语同行评审文章中包含的所需信息,书籍,和论文。此外,用决定系数(r2)确定所选参数之间的相关性。
■文献调查显示,属于62科的165种在乌干达传统上用于治疗伤口。大多数物种属于菊科(14%),豆科(10%),和大齿科(7%)。用于伤口治疗的最常见的植物部分包括叶(48%),根(22%),登船(11%),和茎(7%),主要由膏药(34%)制备,汤剂(13%),以及粉化(25%)。已经调查了54种(33%)植物的伤口愈合活性,111(67%)尚未对其伤口愈合效果进行科学调查。每个使用的部分的伤口愈合植物家族的数量与每个使用的植物部分的百分比之间的皮尔逊相关系数为0.97,每种制备方法的伤口愈合植物家族的数量与每种制备方法的百分比之间的皮尔逊相关系数为0.95,两者都表现出强烈的正标记关系。
■初步研究的具有积极伤口愈合特性的植物需要对可能的最终阶段进行进一步评估,与组成生物活性剂的全面鉴定。此外,具有声称的愈合效果的未经科学研究的植物的伤口愈合潜力需要检查。随后,关于疗效的信息,安全,生物活性原则,和作用机制可能在伤口愈合疗法的未来发展中被证明是有价值的。
UNASSIGNED: Wounds have become a major health challenge worldwide, presenting marked humanistic and economic burdens such as disabilities and death. Annually, approximately 14 million people suffer from wounds worldwide and 80 % of these occur in developing countries like Uganda. In Uganda, besides many cases of daily wound occurrences, approximately 10 % of surgical procedures become septic wounds and consequently lead to increased morbidity and mortality. Accordingly, several ethnomedicinal studies have identified plants used for wound treatment in different parts of Uganda and the wound healing activities of some plants have been reported. However, at present, these information remain largely separated without an all-inclusive repository containing ethnomedicinal and pharmacological information of the plants used for wound healing in Uganda, thus retarding appropriate evaluation. Therefore, this review focused on extensively exploring the plants used for treating cutaneous wounds in Uganda, along with associated ethnomedicinal information and their globally reported pharmacological potential.
UNASSIGNED: Electronic data bases including Google Scholar, PubMed, and Science Direct were searched using key terms for required information contained in English peer reviewed articles, books, and dissertations. Additionally, correlations between selected parameters were determined with coefficient of determination (r2).
UNASSIGNED: The literature survey revealed that 165 species belonging to 62 families are traditionally used to treat wounds in Uganda. Most of the species belonged to families of Asteraceae (14 %), Fabaceae (10 %), and Euphorbiaceae (7 %). The commonest plant parts used for wound treatment include leaf (48 %), root (22 %), stembark (11 %), and stem (7 %), which are prepared majorly by poultice (34 %), decoction (13 %), as well as powdering (25 %). Fifty-four (33 %) of the plant species have been investigated for their wound healing activities whereas, one hundred eleven (67 %) have not been scientifically investigated for their wound healing effects. Pearson correlation coefficient between the number of wound healing plant families per part used and percent of each plant part used was 0.97, and between the number of wound healing plant families per method of preparation and percent of each method of preparation was 0.95, showing in both strong positively marked relationships.
UNASSIGNED: The preliminarily investigated plants with positive wound healing properties require further evaluation to possible final phases, with comprehensive identification of constituent bioactive agents. Additionally, the wound healing potential of the scientifically uninvestigated plants with claimed healing effects needs examination. Subsequently, information regarding efficacy, safety, bioactive principles, and mechanism of action could prove valuable in future development of wound healing therapies.