如今,寻常痤疮治疗通常不成功。粉刺和炎性病变形成的原因之一可能是角鲨烯的过氧化作用,代表人类皮脂主要成分之一的碳氢化合物。这种过氧化作用因太阳辐射而增加。这项工作的目的是建立一种从痤疮皮肤中提取和定量角鲨烯的体内方法,并将结果与皮脂量等生物物理皮肤参数相关联,蛋白质含量和TEWL。健康志愿者用作对照。获得的结果表明,痤疮易发的皮肤含有大量的角鲨烯,and,在角质层区域,它的过氧化物形式存在。此外,Spearman等级相关显示皮脂含量与过氧化角鲨烯之间以及卟啉强度与过氧化角鲨烯之间呈正相关。
Nowadays, acne vulgaris therapies are often unsuccessful. One of the responsible factors for the formation of comedones and inflammatory lesions could be the
peroxidation of squalene, a hydrocarbon representing one of the major components of human sebum. This
peroxidation is increased by solar irradiation. The purpose of this work was to set up an in vivo method for the extraction and quantification of squalene from acne skin and to correlate the results with biophysical skin parameters such as sebum amount, protein content and TEWL. Healthy volunteers were used as control. The results obtained demonstrated that acne-prone skin had a major quantity of squalene, and, in the stratum corneum area, its peroxide form is present. Moreover, Spearman\'s rank correlation showed a positive correlation between sebum content and peroxide squalene and between porphyrin intensity and peroxide squalene.