背景:逆向调节会削弱舒适餐的可喜价值。目的是确定认知干预对逆转厌恶性条件和恢复享乐性餐后反应的影响。
方法:这是一个随机的,假控制,单盲,对12名健康女性进行的平行研究(每组n=6)。舒适餐的奖励值是在不同的日子测量的:在初始暴露时,在厌恶的条件下(在前一天使用掩盖的脂肪超负荷的同一餐)和认知干预后(在测试组中披露厌恶的条件范式与对照组没有解释)。主要结果,消化健康,在摄入前后定期使用分级量表确定。
结果:初次接触时,舒适的餐点产生了有益的体验,这种体验因厌恶的调理而受到损害;在重新接触原始餐点时,认知干预增加了膳食的需求和喜好;改善了消化健康和情绪;倾向于减少餐后饱腹感,腹胀/饱胀;消除不适/疼痛,从而恢复舒适餐的享乐价值。相比之下,假干预没有效果,餐后的感觉仍然像对进餐的反应。
结论:在这项概念验证研究中,我们证明,在健康的女性中,一个温和的,使用认知干预可以逆转对舒适餐的短期获得性厌恶。
结果:政府ID:NCT05897411。
BACKGROUND: Aversive conditioning weakens the gratifying value of a comfort meal. The aim was to determine the effect of a cognitive intervention to reverse aversive conditioning and restore hedonic postprandial response.
METHODS: This was a randomized, sham-controlled, single-blind, parallel
study that was conducted on 12 healthy women (n = 6 in each group). The reward value of a comfort meal was measured on different days: at initial exposure, after aversive conditioning (administration of the same meal with a masked fat overload on the previous day) and after a cognitive intervention (disclosing the aversive conditioning paradigm in the test group vs. no explanation in the control group). The primary outcome, digestive wellbeing, was determined using graded scales at regular intervals before and after ingestion.
RESULTS: At initial exposure, the comfort meal produced a rewarding experience that was impaired using aversive conditioning; upon re-exposure to the original meal, the cognitive intervention increased meal wanting and liking; improved digestive wellbeing and mood; tended to reduce postprandial satiety, bloating/fullness; and abolished discomfort/pain, thereby restoring the hedonic value of the comfort meal. By contrast, sham intervention had no effects, and the postprandial sensations remained like the responses to the offending meal.
CONCLUSIONS: In this proof-of-concept
study, we demonstrate that in healthy women, a mild, short-term acquired aversion to a comfort meal can be reversed using a cognitive intervention.
RESULTS: gov ID: NCT05897411.