Parastomal hernia

造口旁疝
  • 文章类型: Journal Article
    目的:造口旁疝修补术是一个证据不足的领域,围绕最佳管理的不确定性。患者队列中存在相当大的异质性,目前在造口旁疝修补术的报告中没有患者描述的标准化。这项研究的目的是为接受造口旁疝手术修复的患者开发关键患者特征的核心描述符集,以报告所有造口旁疝研究。
    方法:根据对现有文献的回顾,生成了很长的描述符列表。对有造口旁疝修补术经验的患者进行了长期讨论。结肠直肠,普通外科医师和疝气外科医师参加了三轮国际改良Delphi程序,使用9点Likert量表对描述符的重要性进行排名。达到预定阈值的项目被列入最后一组,并在协商一致会议上讨论和批准。
    结果:77名受访者完成了第一轮,23人(29.8%)完成第三轮。在三轮比赛中对86个描述符进行了评级,有52个描述符入围。共识会议批准了最终的核心描述符集,其中包含八个领域的19个描述符:解剖学,污染,疾病,以前的治疗,危险因素,症状,通路和其他疝气。
    结论:核心描述符集合反映了在报告造口旁疝修补术时对外科医生很重要的特征。使用这个商定的核心描述符集可能有助于报告未来的研究。
    OBJECTIVE: Parastomal hernia repair is a poorly evidenced area, with uncertainty around the optimum management. There is considerable heterogeneity within the patient cohort, and currently there is no standardization of patient descriptors in the reporting of parastomal hernia repair. The aim of this study was to develop a core descriptor set of key patient characteristics for patients undergoing surgical repair of a parastomal hernia for reporting in all parastomal hernia research.
    METHODS: A longlist of descriptors was generated from a review of the existing literature. The longlist was discussed with patients with lived experience of parastomal hernia repair. Colorectal, general and hernia surgeons took part in a three-round international modified Delphi process using a nine-point Likert scale to rank the importance of descriptors. Items meeting predetermined thresholds were included in the final set and discussed and ratified at the consensus meeting.
    RESULTS: Seventy seven respondents completed round one, with 23 (29.8%) completing round three. Eighty six descriptors were rated across the three rounds, with 52 descriptors shortlisted. The consensus meeting ratified a final core descriptor set with 19 descriptors across eight domains: anatomy, contamination, disease, previous treatment, risk factors, symptoms, pathway and other hernia.
    CONCLUSIONS: The core descriptor set reflects characteristics that are important to surgeons when reporting on parastomal hernia repair. The use of this agreed core descriptor set may aid the reporting of future studies.
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  • 文章类型: Journal Article
    目的:描述和评估机器人改良Sugarbaker技术与腹膜内垫网(IPUM)修复与回肠导管(ICPSH)相关的造口旁疝的安全性和可行性。
    方法:本回顾性研究,单中心队列研究分析了在2021年7月至2023年7月期间使用改良SugarbakerIPUM技术进行机器人ICPSH修复的15例成年患者的数据.主要终点是疝气复发率和30天发病率。次要终点包括住院时间,转换为开放手术,重新接纳30天,再手术30天.
    结果:患者平均年龄为69.1岁,53.3%为女性。大多数患者(86.6%)接受了根治性膀胱切除术作为指征手术。平均手术时间为249分钟,没有转换为开放手术。30天并发症发生率为26.7%,平均住院时间为3.6天。没有疝气复发,肾积水,在平均15.2个月的随访期间,影像学检查发现肌酐升高或导管扩张提示引流不良.
    结论:机器人改良SugarbakerIPUM技术对于IC患者的PSH修复似乎是安全可行的,有希望的短期结果。需要进行更大队列和更长随访的进一步研究,以确认其长期疗效并确定其在ICPSH管理中的作用。
    OBJECTIVE: To describe and evaluate safety and feasibility of the robotic modified Sugarbaker technique with intraperitoneal underlay mesh (IPUM) for repairing parastomal hernias associated with ileal conduits (ICPSH).
    METHODS: This retrospective, single-center cohort study analyzed data from 15 adult patients who underwent robotic ICPSH repair using the modified Sugarbaker IPUM technique between July 2021 and July 2023. The primary endpoints were hernia recurrence rates and 30-day morbidity. Secondary endpoints included length of stay, conversion to open surgery, 30-day readmission, and 30-day reoperation.
    RESULTS: The mean patient age was 69.1 years, and 53.3% were female. Most patients (86.6%) had undergone radical cystectomy as the index surgery. The mean operative time was 249 min, with no conversions to open surgery. The 30-day complication rate was 26.7%, and the mean hospital stay was 3.6 days. No hernia recurrences, hydronephrosis, rise in creatinine or distended conduit on imaging suggesting poor drainage were observed during a mean follow-up of 15.2 months.
    CONCLUSIONS: The robotic modified Sugarbaker IPUM technique appears safe and feasible for PSH repair in IC patients, with promising short-term outcomes. Further studies with larger cohorts and longer follow-up are needed to confirm its long-term efficacy and establish its role in ICPSH management.
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  • 文章类型: Journal Article
    背景:这篇综述旨在总结已发表的关于网状物预防结直肠手术中造口旁疝作用的系统综述的发现和结论。
    方法:对网片在预防造口旁疝中的作用进行了系统综述。截至2023年11月,搜索了PubMed和Scopus。主要结果是网状物的有效性和安全性。通过临床和放射学检测到的疝发生率以及手术修复的必要性来评估疗效。而安全性是通过总体并发症的发生率来评估的.
    结果:对19项系统评价进行了评估,其中7项仅包括结肠造口的患者,12项包括回肠造口或结肠造口的患者。除一项外,在所有评论中,网片的使用显着降低了临床发现的造口旁疝的风险。七篇评论报道了使用网片在放射学上发现的造口旁疝的风险显着降低。临床检测和放射学检测的造口旁疝的合并风险比分别为0.33(95CI:0.26-0.41)和0.55(95CI:0.45-0.68),分别。六篇评论报告说,使用网片时,手术修复的需求显着减少,而六篇评论发现对疝气修复的需求相似。手术疝修补术的合并风险比为0.46(95CI:0.35-0.62)。8篇综述报告两组并发症相似。并发症的合并风险比为0.81(95CI:0.66-1)。
    结论:使用外科网片预防造口旁疝可能是有效和安全的,而不会增加总体并发症的风险。
    BACKGROUND: This umbrella review aimed to summarize the findings and conclusions of published systematic reviews on the prophylactic role of mesh against parastomal hernias in colorectal surgery.
    METHODS: PRISMA-compliant umbrella overview of systematic reviews on the role of mesh in prevention of parastomal hernias was conducted. PubMed and Scopus were searched through November 2023. Main outcomes were efficacy and safety of mesh. Efficacy was assessed by the rates of clinically and radiologically detected hernias and the need for surgical repair, while safety was assessed by the rates of overall complications.
    RESULTS: 19 systematic reviews were assessed; 7 included only patients with end colostomy and 12 included patients with either ileostomy or colostomy. The use of mesh significantly reduced the risk of clinically detected parastomal hernias in all reviews except one. Seven reviews reported a significantly lower risk of radiologically detected parastomal hernias with the use of mesh. The pooled hazards ratio of clinically detected and radiologically detected parastomal hernias was 0.33 (95%CI: 0.26-0.41) and 0.55 (95%CI: 0.45-0.68), respectively. Six reviews reported a significant reduction in the need for surgical repair when a mesh was used whereas six reviews found a similar need for hernia repair. The pooled hazards ratio for surgical hernia repair was 0.46 (95%CI: 0.35-0.62). Eight reviews reported similar complications in the two groups. The pooled hazard ratio of complications was 0.81 (95%CI: 0.66-1).
    CONCLUSIONS: The use of surgical mesh is likely effective and safe in the prevention of parastomal hernias without an increased risk of overall complications.
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  • 文章类型: Journal Article
    目的:综述Lap-re-Do技术治疗大型造口旁疝的安全性和有效性。
    方法:回顾性分析2010年5月至2019年12月在复旦大学附属华山医院行Lap-re-Do技术治疗的81例大型造口旁疝患者的复发及并发症。患者应该能够完成随访。有了这样的标准,我们包括40例Lap-re-DoKeyhole患者和41例Lap-re-DoSugarbaker患者。观察时间定义为复发时间,死亡,或最后一次非事件访问。
    结果:在大型造口旁疝中,Lap-re-Do的复发率为25.9%,并发症发生率为16.0%,平均随访时间41.1±17.8个月,再次手术率为9.9%。Lap-re-DoKeyhole修复后的复发率为40%(16/40),Lap-re-DoSugarbaker修复后的复发率为12.2%(5/41)。术后并发症发生率为12.5%,术后并发症发生率为19.5%,术后并发症发生率为19.5%。随访期间,术后并发症发生率为15%,术后并发症发生率为4.9%。大多数再次手术以复发为标志。
    结论:大型造口旁疝仍难以治疗。建议将Lap-re-DoSugarbaker作为关闭疝气环的适当程序,移除冗长的结肠造口术,并有效降低复发率和并发症发生率。
    OBJECTIVE: To review the safety and efficacy of Lap-re-Do technique in the treatment of large parastomal hernia.
    METHODS: We retrospectively analyzed the recurrence and complications of 81 patients with large parastomal hernia who underwent Lap-re-Do technique in Huashan Hospital of Fudan University from May 2010 to December 2019. And the patients should be able to complete follow-up. With such criteria, we included 40 Lap-re-Do Keyhole patients and 41 Lap-re-Do Sugarbaker patients. Observation time was defined as time to recurrence, death, or last nonevent visit.
    RESULTS: In large parastomal hernias, Lap-re-Do had a recurrence rate of 25.9% and complication rate of 16.0%, and reoperation rate of 9.9% during the average follow-up time of 41.1 ± 17.8 months. Recurrence rates were 40% (16/40) after Lap-re-Do Keyhole repair and 12.2% (5/41) after Lap-re-Do Sugarbaker repair. Complication rates were 12.5% after Lap-re-Do keyhole and 19.5% after Lap-re-Do Sugarbaker repair Re-operation rates referred to Lap-re-Do keyhole repair were 15% and Lap-re-Do Sugarbaker repair 4.9% during follow-up.The majority of reoperations were indicated by recurrence.
    CONCLUSIONS: Large parastomal hernias are still difficult to be treated. Lap-re-Do Sugarbaker is recommended as an appropriate procedure to close the hernia ring, removing the lengthy colostomy, and effectively reduce recurrence and complication rates.
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  • 文章类型: Journal Article
    目的:建立基于机器学习的永久性结肠造口术患者术后造口旁疝(PSH)风险预测模型,协助护士识别高危人群并制定预防性护理策略。
    方法:对2017年6月至2023年6月在安徽医科大学第二附属医院行永久性结肠造口的495例结直肠癌患者进行病例对照研究,随访1年。根据术后1年内的PSH发生率将患者分为PSH和非PSH组。数据分为训练(70%)和测试(30%)集。使用最小绝对收缩和选择算子(LASSO)回归进行变量选择,并利用Logistic回归(LR)建立了二元分类预测模型,支持向量分类(SVC)K近邻(KNN),随机森林(RF),轻型梯度增压机(LGBM),和极端梯度提升(XgBoost)。二进制分类标签对于PSH发生表示为1,对于没有PSH发生表示为0。通过5倍交叉验证优化参数。使用曲线下面积(AUC)评估模型性能,特异性,灵敏度,准确度,正预测值,负预测值,和F1得分。使用决策曲线分析(DCA)评估临床效用,使用Shapley加法解释(SHAP)增强了模型解释,并使用列线图实现了模型可视化。
    结果:1年内PSH的发生率为29.1%(144例患者)。在测试的模型中,RF模型显示出最高的辨别能力,AUC为0.888(95%CI:0.881-0.935),连同优越的特异性,准确度,灵敏度,F1得分。它还在DCA曲线上显示出最高的临床净效益。SHAP分析确定了与PSH风险相关的前10个影响变量:体重指数(BMI),操作持续时间,慢性阻塞性肺疾病(COPD)的病史和状态,前白蛋白,肿瘤淋巴结转移(TNM)分期,造口部位,腹直肌厚度(TRAM),C反应蛋白CRP,美国麻醉师学会身体状况分类(ASA),和气孔直径。来自SHAP图的这些见解说明了这些因素如何影响个体PSH结果。列线图用于模型可视化。
    结论:随机森林模型在预测结肠PSH方面表现出稳健的预测性能和临床相关性。该模型有助于早期识别高危患者并指导预防护理。
    OBJECTIVE: To develop a machine learning-based risk prediction model for postoperative parastomal hernia (PSH) in colorectal cancer patients undergoing permanent colostomy, assisting nurses in identifying high-risk groups and devising preventive care strategies.
    METHODS: A case-control study was conducted on 495 colorectal cancer patients who underwent permanent colostomy at the Second Affiliated Hospital of Anhui Medical University from June 2017 to June 2023, with a 1-year follow-up period. Patients were categorized into PSH and non-PSH groups based on PSH occurrence within 1-year post-operation. Data were split into training (70%) and testing (30%) sets. Variable selection was performed using Least Absolute Shrinkage and Selection Operator (LASSO) regression, and binary classification prediction models were established using Logistic Regression (LR), Support Vector Classification (SVC), K Nearest Neighbor (KNN), Random Forest (RF), Light Gradient Boosting Machine (LGBM), and Extreme Gradient Boosting (XgBoost). The binary classification label denoted 1 for PSH occurrence and 0 for no PSH occurrence. Parameters were optimized via 5-fold cross-validation. Model performance was evaluated using Area Under Curve (AUC), specificity, sensitivity, accuracy, positive predictive value, negative predictive value, and F1-score. Clinical utility was evaluated using decision curve analysis (DCA), model explanation was enhanced using shapley additive explanation (SHAP), and model visualization was achieved using a nomogram.
    RESULTS: The incidence of PSH within 1 year was 29.1% (144 patients). Among the models tested, the RF model demonstrated the highest discrimination capability with an AUC of 0.888 (95% CI: 0.881-0.935), along with superior specificity, accuracy, sensitivity, and F1 score. It also showed the highest clinical net benefit on the DCA curve. SHAP analysis identified the top 10 influential variables associated with PSH risk: body mass index (BMI), operation duration, history and status of chronic obstructive pulmonary disease (COPD), prealbumin, tumor node metastasis (TNM) staging, stoma site, thickness of rectus abdominis muscle (TRAM), C-reactive protein CRP, american society of anesthesiologists physical status classification (ASA), and stoma diameter. These insights from SHAP plots illustrated how these factors influence individual PSH outcomes. The nomogram was used for model visualization.
    CONCLUSIONS: The Random Forest model demonstrated robust predictive performance and clinical relevance in forecasting colonic PSH. This model aids in early identification of high-risk patients and guides preventive care.
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  • 文章类型: Journal Article
    背景:关于外科医生病例体积与腹侧疝修补术后的术中或术后并发症之间潜在关系的文献仍然很少。
    方法:从前瞻性维持的法国疝俱乐部登记处选择2011年至2023年接受腹疝修补术的患者。结果变量为:术中事件,术后一般并发症,手术部位的发生,手术部位感染,重症监护病房(ICU)的长度,随访期间患者报告的瘢痕膨出。外科医生的年病例量分为1-5、6-50、51-100、101-125和>125例,并使用单变量和多变量分析评估其与结果体积的关联。
    结果:在研究期间,199名名义或临时成员注册了15,332例腹侧疝修复术,包括7869个小学,6173切口,造口旁疝修补术212例.在单变量分析中,外科医生的年病例量与所有术后研究结果显著相关。经过多元回归分析,每年的病例量仍然与术中并发症显著相关,术后一般并发症和ICU住院时间。初次修复与较少的术中和术后并发症独立相关。
    结论:在对腹侧疝修补术的大型注册表的当前多变量分析中,较高的外科医生年病例量与较少的术后一般并发症和较短的住院时间显着相关。但手术部位的发生率却更少,患者报告的疤痕凸起也较少。外科医生的病例混合因素如疝气类型对并发症发生率有显著影响。
    BACKGROUND: Literature on a potential relationship between surgeon case volume and intra- or postoperative complications after ventral hernia repair remains scarce.
    METHODS: Patients who underwent ventral hernia repair between 2011 and 2023 were selected from the prospectively maintained French Hernia-Club Registry. Outcome variables were: intraoperative events, postoperative general complications, surgical site occurrences, surgical site infections, length of intensive care unit (ICU), and patient-reported scar bulging during follow-up. Surgeons\' annual case volume was categorized as 1-5, 6-50, 51-100, 101-125, and > 125 cases, and its association with outcome volume was evaluated using uni- and multivariable analyses.
    RESULTS: Over the study period, 199 titular or temporary members registered 15,332 ventral hernia repairs, including 7869 primary, 6173 incisional, and 212 parastomal hernia repairs. In univariate analysis, surgeons\' annual case volume was significantly related with all the postoperative studied outcomes. After multivariate regression analysis, annual case volume remained significantly associated with intra-operative complications, postoperative general complications and length of ICU stay. A primary repair was independently associated with fewer intra- and post-operative complications.
    CONCLUSIONS: In the present multivariable analysis of a large registry on ventral hernia repairs, higher surgeon annual case volume was significantly related with fewer postoperative general complications and a shorter length of stay, but not with fewer surgical site occurrences, nor with less patient-reported scar bulging. Factors in the surgeons\' case mix such as the type of hernia have significant impact on complication rates.
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  • 文章类型: Journal Article
    造口旁疝是造口术形成的必然结果,其修复仍然是许多外科医生的挑战。具有多种分类系统和多种疝修复技术,从缝合到网状修复,关于最佳修复方法的文献仍然很少。作者描述了最常用的技术,讨论预防措施,并回顾了当前有关围手术期结局和疝复发的文献。
    Parastomal hernias are an inevitable consequence of ostomy formation and their repairs remain a challenge to many surgeons. With multiple systems of classification and a multitude of techniques for hernia repair ranging from suture to mesh repair, the literature remains sparse with regards to the optimal method of repair. The authors describe the most commonly adopted techniques, discuss preventative measures, and review the current literature in the context of perioperative outcomes and hernia recurrence.
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  • 文章类型: Journal Article
    造口旁疝(PSH)难以管理,并且术后复发率和并发症率高。Sugarbaker和三维(3-D)网状修复是PSH手术治疗的常用方法。然而,这些手术技术的有效性和安全性尚未得到充分比较.包括2012年8月至2023年5月在我们中心接受3-D网状物或Sugarbaker修复的PSH患者。我们回顾性分析了他们的人口统计学数据和术后结果。主要结果指标是1年随访时的复发率。共纳入86例患者,3-D网格组(62%)53例,Sugarbaker组(38%)33例。大多数病例(73%)是腹腔镜入路。3-D网组1年随访复发率为15%(8例),Sugarbaker组为24%(8例)。无统计学意义(P=0.29)。此外,3-D网片组和Sugarbaker组在住院时间或短期和长期并发症方面无差异.Sugarbaker和3-D网状修复在PSH的手术治疗中具有相似的临床疗效。需要进一步的随机对照试验来证实这些结果。试用注册号。这项研究在clinicaltrials.gov(NCT06077318)进行了回顾性注册。
    Parastomal hernias (PSH) are difficult to manage and associated with high rates of postoperative recurrence and complications. Sugarbaker and three-dimensional (3-D) mesh repair are commonly used methods for the surgical treatment of PSH. However, the efficacy and safety of these surgical techniques have not been adequately compared. Patients with PSH who received 3-D mesh or Sugarbaker repair at our center from August 2012 to May 2023 were included. We retrospectively analyzed their demographic data and postoperative outcomes. The primary outcome measure was the recurrence rate at 1-year follow-up. A total of 86 patients were enrolled, involving 53 in the 3-D mesh (62%) group and 33 in the Sugarbaker (38%) group. Most cases (73%) involved were the laparoscopic approach. The recurrence rate at 1-year follow-up was 15% (eight cases) in the 3-D mesh group and 24% (eight cases) in the Sugarbaker group, with no statistical significance (P = 0.29). Additionally, no differences were observed between the 3-D mesh and Sugarbaker groups in the length of hospitalization or in short- and long-term complications. Sugarbaker and 3-D mesh repair have similar clinical efficacy in the surgical treatment of PSH. Further randomized controlled trials are required to confirm these results.Trial registration number.This study was retrospectively registered at clinicaltrials.gov (NCT06077318).
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  • 文章类型: Journal Article
    背景:本研究探讨了在开放根治性膀胱切除术和回肠导管改道期间预防性网状物植入在预防造口旁疝(PH)中的疗效。尽管PH是常见的并发症,预防方法的开发不足。
    方法:一名飞行员,单中心,前瞻性队列研究涉及5例接受网状物植入手术的患者。监测人口统计学和临床特征,包括PH的发生率,操作时间,失血,和住院时间。
    结果:在术后9.1±3.2个月的平均随访期间,在患者组中未观察到PH的发生。尽管在涉及小肠开放的手术区域植入异物存在风险,未发现感染并发症.
    结论:根治性膀胱切除术中的预防性网状物植入回肠导管分流似乎是预防PH的有效措施。需要进一步的广泛研究来明确确认在这种情况下使用网状物的有效性和安全性。
    BACKGROUND: This study examines the efficacy of prophylactic mesh implantation during open radical cystectomy with ileal conduit diversion in preventing parastomal hernias (PH). Despite PH being a common complication, prophylactic methods have been underexplored.
    METHODS: A pilot, single-center, prospective cohort study was conducted involving five patients undergoing surgery with mesh implantation. Demographic and clinical characteristics were monitored, including the incidence of PH, operation time, blood loss, and hospitalization duration.
    RESULTS: During the mean follow-up period of 9.1±3.2 months post-operation, no occurrences of PH were observed in the patient group. Despite the risks associated with implanting foreign material in an area of surgery involving open small intestine, no infectious complications were noted.
    CONCLUSIONS: Prophylactic mesh implantation in radical cystectomy with ileal conduit diversion appears to be an effective preventive measure against PH. Further extensive studies are required to definitively confirm the efficacy and safety of mesh use in this context.
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  • 文章类型: Journal Article
    目的:研究术前身体形态分析是否可以识别出有造口旁疝(PH)风险的患者,这是根治性膀胱切除术(RC)后的常见并发症。
    方法:纳入所有在2010年至2020年期间接受RC的患者,术前以及术后1年和2年进行横断面成像。使用AquariusIntuition软件,根据在L3椎体水平获得的术前轴向计算机断层扫描图像确定骨骼肌质量和总脂肪质量(FM)。根据骨骼肌指数(SMI)和FM指数(FMI)的一致定义来分配肌肉减少症和肥胖。使用Moreno-Matias和欧洲疝协会标准对PH进行分级。使用二元逻辑回归和递归划分来识别有PH风险的患者。具有对数秩和Cox比例风险模型的Kaplan-Meier方法包括临床和基于图像的参数,以确定无PH生存的预测因子。
    结果:共有367例患者被纳入最终分析,159(43%)发展为PH。当使用二元逻辑回归时,高FMI(比值比[OR]1.63,P<0.001)和低SMI(OR0.96,P=0.039)是PH风险的主要驱动因素.一个只依赖于FMI的简化模型,SMI,术前白蛋白改善了PH风险患者的分类。关于Kaplan-Meier分析,肥胖或肥胖且肌少症患者的无PH生存率显著降低(P<0.001).
    结论:身体形态分析确定FMI和SMI是RC后PH最一致的预测因子。
    OBJECTIVE: To investigate whether preoperative body morphometry analysis can identify patients at risk of parastomal hernia (PH), which is a common complication after radical cystectomy (RC).
    METHODS: All patients who underwent RC between 2010 and 2020 with available cross-sectional imaging preoperatively and at 1 and 2 years postoperatively were included. Skeletal muscle mass and total fat mass (FM) were determined from preoperative axial computed tomography images obtained at the level of the L3 vertebral body using Aquarius Intuition software. Sarcopenia and obesity were assigned based on consensus definitions of skeletal muscle index (SMI) and FM index (FMI). PH were graded using both the Moreno-Matias and European Hernia Society criteria. Binary logistic regression and recursive partitioning were used to identify patients at risk of PH. The Kaplan-Meier method with log-rank and Cox proportional hazards models included clinical and image-based parameters to identify predictors of PH-free survival.
    RESULTS: A total of 367 patients were included in the final analysis, with 159 (43%) developing a PH. When utilising binary logistic regression, high FMI (odds ratio [OR] 1.63, P < 0.001) and low SMI (OR 0.96, P = 0.039) were primary drivers of risk of PH. A simplified model that only relied upon FMI, SMI, and preoperative albumin improved the classification of patients at risk of PH. On Kaplan-Meier analysis, patients who were obese or obese and sarcopenic had significantly worse PH-free survival (P < 0.001).
    CONCLUSIONS: Body morphometry analysis identified FMI and SMI to be the most consistent predictors of PH after RC.
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