■泮托拉唑是最广泛使用的质子泵抑制剂之一,但在使用过程中很少发生过敏反应。报告这两种情况的目的是表明泮托拉唑不是没有问题的药物;它也会引起过敏反应。
■一名42岁的妇女因消化不良而出现在急诊科。立即在输注泮托拉唑结束时,舌头开始麻木,全身瘙痒,呼吸困难.服用泮托拉唑40毫克胶囊半小时后,一名58岁的妇女开始出现面部发红,舌头增厚,瘙痒,腹胀,和头晕。动脉压为80/60mmHg,脉搏150/分钟,而饱和度已降至88%。在这两种情况下,流体,肾上腺素,抗组胺药,甲基强的松龙,和钙立即开始。一般条件改善后,两名患者均出院回家。
■第一例涉及静脉注射泮托拉唑后的过敏反应,第二种情况与口服后出现过敏反应有关。
■卫生工作者需要了解口服和肠胃外泮托拉唑患者发生过敏反应的可能性。
结论:PPI通常是安全的,副作用比例低,为1-3%。尽管对PPI的过敏反应很少见,文献中也报道了类过敏反应的病例。在口服和肠胃外给药的过敏反应的鉴别诊断中,应考虑服用泮托拉唑引起的过敏反应。医生和药剂师在处方泮托拉唑和其他PPI时应该非常小心,尤其是老年人。
UNASSIGNED: Pantoprazole is one of the most widely used proton pump inhibitors, but anaphylaxis occurs rarely during its use. The purpose of reporting these two cases is to show that
pantoprazole is not a drug without problems; it can also cause anaphylactic reactions.
UNASSIGNED: A 42-year-old woman presented to the emergency department due to dyspeptic complaints. Immediately at the end of the infusion of pantoprazole, there started to be numbness of the tongue, itching all over the body, and difficulty in breathing. Half an hour after taking a
pantoprazole 40 mg capsule, a 58-year-old woman started to experience redness of the face, thickening of the tongue, itching, bloating, and dizziness. Arterial pressure was 80/60 mmHg, pulse 150/minute, while saturation had dropped to 88%. In both cases, fluids, adrenaline, antihistamines, methylprednisolone, and calcium were immediately started. After the improvement of their general conditions, both patients were discharged home.
UNASSIGNED: The first
case relates to anaphylaxis after the intravenous administration of
pantoprazole, and the second
case relates to the appearance of anaphylaxis after its oral administration.
UNASSIGNED: Health workers need to be informed about the possibility of anaphylaxis in patients taking both oral and parenteral pantoprazole.
CONCLUSIONS: PPIs are generally safe, with a low percentage of side effects of 1-3%.Although hypersensitive reactions to PPIs are rare, cases of anaphylactoid reactions have also been reported in the literature.Anaphylaxis caused by taking pantoprazole should be considered in the differential diagnosis of anaphylaxis in both oral and parenteral administration of the drug.Doctors and pharmacists should be very careful when prescribing pantoprazole and other PPIs, especially to the elderly.