Post-orgasmic illness syndrome (POIS) is a rare condition characterized by debilitating symptoms following ejaculation. We present a case of a 25-year-old male with flu-like symptoms post-ejaculation since age 17. Despite minimal relief from conventional treatments, a comprehensive evaluation led to the diagnosis of POIS and successful management with niacinamide therapy. The presentation of flu-like symptoms following ejaculation in this case raises several questions regarding the underlying pathophysiology. While the exact cause of his symptoms remains elusive, the resolution achieved with niacinamide therapy underscores the importance of considering alternative treatment modalities in complex cases. The role of varicocele in symptom manifestation, if any, also warrants consideration, as varicocele has been associated with male infertility and testicular dysfunction.

UNASSIGNED: The COVID-19 pandemic is a new phenomenon and has affected the population\'s lifestyle in many ways, such as panic buying (the so-called \"hamster shopping\"), adoption of home-office, and decline in retail shopping. For transportation planners and operators, it is interesting to analyze the spatial factors\' role in the demand patterns at a POI (Point of Interest) during the COVID-19 lockdown viz-a-viz before lockdown.
UNASSIGNED: This study illustrates a use-case of the POI visitation rate or popularity data and other publicly available data to analyze demand patterns and spatial factors during a highly dynamic and disruptive event like COVID-19. We develop regression models to analyze the correlation of the spatial and non-spatial attributes with the POI popularity before and during COVID-19 lockdown in Munich by using lockdown (treatment) as a dummy variable, with main and interaction effects.
UNASSIGNED: In our case-study for Munich, we find consistent behavior of features like stop distance and day-of-the-week in explaining the popularity. The parking area is found to be correlated only in the non-linear models. Interactions of lockdown with POI type, stop-distance, and day-of-the-week are found to be strongly significant. The results might not be transferable to other cities due to the presence of different city-specific factors.
UNASSIGNED: The findings from our case-study provide evidence of the impact of the restrictions on POIs and show the significant correlation of POI-type and stop distance with POI popularity. These results suggest local and temporal variability in the impact due to the restrictions, which can impact how cities adapt their transport services to the distinct demand and resulting mobility patterns during future disruptive events.

UNASSIGNED: Postorgasmic illness syndrome (POIS) is a rare condition in which individuals develop generalized and flu-like symptoms after ejaculation. Several mechanisms and treatments for this disorder have been proposed but many questions remain.
UNASSIGNED: We sought to present a summary of literature to date and highlight common symptoms, associated features, comorbidities, and laboratory findings in a clinical sample of patients with POIS.
UNASSIGNED: We conducted a retrospective chart review of 6 patients with POIS in our clinic and presented compiled results.
UNASSIGNED: We identified newly described non-flu-like presentations, onset of symptoms with high states of arousal without ejaculation, and presence of psychiatric comorbidity in a majority of patients. We did not identify a postorgasm allergic response with bloodwork available.
UNASSIGNED: POIS remains a poorly understood condition that likely comprises a number of different clinical entities. Further research on a larger clinical sample is necessary to better characterize POIS and understand its biological and psychological basis.