%0 Journal Article
%T Case series: expanding diagnostic markers in postorgasmic illness syndrome.
%A Rosetti L
%A Kanani A
%A Witherspoon L
%A Flannigan R
%A Elliott S
%J Sex Med
%V 11
%N 2
%D Apr 2023
%M 36910704
%F 2.523
%R 10.1093/sexmed/qfac021
%X <B>UNASSIGNED: </B>Postorgasmic illness syndrome (POIS) is a rare condition in which individuals develop generalized and flu-like symptoms after ejaculation. Several mechanisms and treatments for this disorder have been proposed but many questions remain.<BR><B>UNASSIGNED: </B>We sought to present a summary of literature to date and highlight common symptoms, associated features, comorbidities, and laboratory findings in a clinical sample of patients with POIS.<BR><B>UNASSIGNED: </B>We conducted a retrospective chart review of 6 patients with POIS in our clinic and presented compiled results.<BR><B>UNASSIGNED: </B>We identified newly described non-flu-like presentations, onset of symptoms with high states of arousal without ejaculation, and presence of psychiatric comorbidity in a majority of patients. We did not identify a postorgasm allergic response with bloodwork available.<BR><B>UNASSIGNED: </B>POIS remains a poorly understood condition that likely comprises a number of different clinical entities. Further research on a larger clinical sample is necessary to better characterize POIS and understand its biological and psychological basis.