背景:阿尔茨海默病(AD)是一种慢性神经退行性疾病,占全球所有痴呆病例的50%以上。人们对AD的危险因素有广泛的共识;然而,明确的病因尚不清楚。证据表明,炎症介导的疾病模型,例如发现牙龈卟啉单胞菌引起的牙周病(P.牙龈),在AD进展中发挥作用。
目的:本研究旨在系统回顾关于牙龈卟啉单胞菌与AD之间关联的文献,并确定跨研究使用的测量牙龈卟啉单胞菌参与AD的方法的同质性。
方法:我们系统地搜索了Cochrane文库的研究,OvidMedline,PubMed,WebofScience,WHOLIS,谷歌学者数据库,和已确定研究的参考清单。
结果:636项确定的记录中有6项研究符合所有资格标准。结果表明,牙龈卟啉单胞菌及其各种毒力因子引起的AD没有明确的病理生理学。在有关AD或牙龈卟啉单胞菌及其毒力因子的测量方法的文献中没有发现共识。
结论:纳入的研究表明,牙龈卟啉单胞菌在全身性炎症过程中起作用,导致脑脊液炎症,间接导致AD的发病和进展加快。我们纳入的研究揭示了AD和/或牙龈卟啉单胞菌及其毒力因子测量方法的异质性,这开启了关于可能的标准化的好处和弱点的讨论。
BACKGROUND: Alzheimer\'s disease (AD) is a chronic neurodegenerative disease that accounts for more than 50% of all dementia cases worldwide. There is wide consensus on the risk factors of AD; however, a clear etiology remains unknown. Evidence suggests that the inflammatory-mediated disease model, such as that found with periodontal disease due to Porphyromonas gingivalis (P. gingivalis), plays a role in AD progression.
OBJECTIVE: This study aims to systematically
review the literature on the association between P. gingivalis to AD, and to identify the homogeneity of the methods used across studies to measure P. gingivalis involvement in AD.
METHODS: We systematically searched studies on Cochrane library, Ovid Medline, PubMed, Web of Science, WHOLIS, Google Scholar databases, and reference lists of identified studies.
RESULTS: 6 studies out of 636 identified records fulfilled all eligibility criteria. Results showed no clear pathophysiology of AD due to P. gingivalis and its various virulence factors. No consensus was found in the literature pertaining to the method of measurement of AD or P. gingivalis and its virulence factors.
CONCLUSIONS: The included studies suggest that P. gingivalis bacteria play a role in the process of systemic inflammation which leads to cerebrospinal fluid inflammation and indirectly cause hastening of AD onset and progression. Our included studies revealed heterogeneity in the methodologies of measurement of AD and/or P. gingivalis and its virulence factors, which opens discussion about the benefits and weakness of possible standardization.