背景:以前,化脓菌最近更名为化脓菌。这种机会性细菌与动物的各种化脓性感染有关。大多数涉及化脓杆菌的研究都是病例报告,然而,很少有调查关注化脓性弧菌感染的主要方面,涉及病例系列研究设计。
目的:本研究的目的是回顾性评估选定的流行病学和临床方面,以及2002年至2012年144例家畜化脓性产热杆菌感染的体外抗菌药物敏感性模式。
方法:T.化脓性动物是从牛的不同临床标本中分离出来的,山羊,绵羊,猪,马,狗,还有水牛.相关性通过卡方检验或Fisher精确检验进行评估。
结果:乳腺炎(45.1%),脓肿(18.0%),肺炎(11.1%),和淋巴结炎(9.0%)是最常见的临床表现。此外,该生物还从败血症病例的其他杂项临床标本中分离出来,脑炎,子宫积脓,前列腺炎,睾丸炎,精囊炎,心包炎,和脐炎.在化脓性嗜酸杆菌感染和年龄之间没有观察到统计关联,性别,或整个研究的季节。对病原体最有效的药物是氟苯尼考(99.1%),头孢哌酮(96.0%),头孢氨苄(95.0%),和头孢噻呋酯(94.8%)。观察到对甲氧苄啶-磺胺甲恶唑的高耐药率(49.3%),其次是诺氟沙星(10.9%)和四环素(9.2%)。
结论:本研究强调了家养动物化脓性T.pyogenes感染的临床表现和机会行为的多样性,以乳腺炎为主,脓肿,肺炎,和淋巴结炎。它还加强了在开始治疗之前了解易感性特征的重要性,改善抗菌治疗方法。
BACKGROUND: Formerly, Arcanobacterium pyogenes was recently renamed Trueperella pyogenes. This opportunistic bacterium is related to miscellaneous pyogenic infections in animals. Most studies involving T. pyogenes are case reports, whereas few surveys have focused the major aspects of T. pyogenes infections involving a case series
study design.
OBJECTIVE: The aim of this
study was to retrospectively evaluate selected epidemiological and clinical aspects, as well as the in vitro antimicrobial susceptibility pattern of 144 cases of T. pyogenes infections among domestic animals from 2002 to 2012.
METHODS: T. pyogenes was isolated from different clinical specimens from cattle, goats, sheep, pigs, horses, dogs, and buffaloes. Correlations were assessed by the Chi-square or Fisher\'s exact tests.
RESULTS: Mastitis (45.1%), abscesses (18.0%), pneumonia (11.1%), and lymphadenitis (9.0%) were the most common clinical manifestations. In addition, the organism was also isolated from other miscellaneous clinical specimens from cases of septicemia, encephalitis, pyometra, prostatitis, orchitis, seminal vesiculitis, pericarditis, and omphalitis. No statistical association was observed between T. pyogenes infections and age, gender, or season across the
study. The most effective drugs against the pathogen were florfenicol (99.1%), cefoperazone (96.0%), cephalexin (95.0%), and ceftiofur (94.8%). High resistance rates were observed against trimethoprim-sulfamethoxazole (49.3%), followed by norfloxacin (10.9%) and tetracycline (9.2%).
CONCLUSIONS: This
study highlights the diversity of clinical manifestations and the opportunistic behavior of T. pyogenes infections in domestic animals, with predominance of mastitis, abscesses, pneumonia, and lymphadenitis. It also reinforces the importance of knowing the susceptibility profile before initiating therapy, to improve antimicrobial therapy approaches.