背景:上皮性卵巢癌(EOC)是最常见的卵巢癌类型。约90%的卵巢肿瘤是上皮性的。目前EOC的治疗包括手术切除肿瘤,然后联合化疗。虽然大多数患者达到完全缓解,许多EOC会复发并发展化学抗性。癌细胞可以适应多种压力刺激,变得有抵抗力。因此,在疾病期间对抗抗性细胞的新方法正在研究中。最近,外泌体,这反映了正常和病理条件下的细胞行为,如上皮性卵巢癌,作为诊断和治疗的新生物标志物具有学术兴趣。因此,本研究旨在调查外泌体在EOC中的研究成果。方法:通过搜索Scopus中的关键词,采用文献计量学方法分析2022年10月15日外泌体和上皮性卵巢癌的出版物,PubMed和谷歌学者。年度科学出版物,作者,引文,期刊,共同作者,使用MicrosoftOfficeExcel和VOS查看器分析和绘制关键字共现。自2015年以来,截至2022年10月15日,共发表了39篇原创期刊文章和3篇评论。结果:研究结果表明,中国是研究产出最多的国家,国际合作,组织,作者,和赞助。顶级期刊是《卵巢研究杂志》,Oncotarget,肿瘤生物学,都在美国。中国的顶尖院校是上海交通大学。最高作者是王希鹏。共现分析表明,学术界对以下方面的兴趣:1)1)外泌体作为EOC的预后生物标志物以及它们在细胞增殖和迁移中的作用。2)外泌体通过不同机制在转移中的作用;3)外泌体在卵巢癌细胞上皮间质转化中的作用;4)EVs在EOC中的诊断作用;5)通过miRNA的外泌体转移赋予EOC化学耐药性。结论:外泌体和EOC的研究有增加的趋势,中国比其他国家更参与研究,财政支持,和国际合作。这些发现可以帮助研究人员理解该领域赞助商感兴趣的新颖想法和主题。
Background: Epithelial
ovarian cancer (EOC) is the most common type of
ovarian cancer. About 90% of ovary tumors are epithelial. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients achieve complete remission, many EOCs will recur and develop chemoresistance. The cancer cells can adapt to several stress stimuli, becoming resistant. Therefore, new ways to fight resistant cells during the disease are being studied. Recently, exosomes, which reflect cell behavior in normal and pathological conditions such as epithelial
ovarian cancer, are of academic interest as new biomarkers for diagnosis and therapy. Consequently, the current study aimed to investigate the research output of exosomes in EOC. Method: A bibliometric method was used for analyzing publications on exosome and epithelial
ovarian cancer from the beginning to 15 October 2022 by searching keywords in Scopus, PubMed and Google scholar. Annual scientific publications, authors, citations, journals, co-authorships, and keywords co-occurrence were analyzed and plotted using Microsoft Office Excel and VOS viewer. 39 original journal articles and 3 reviews have been published since 2015 up to 15 October 2022. Results: The findings showed that China is the top country in research output, international collaborations, organization, author, and sponsorship. The top journals were the Journal of
Ovarian Research, Oncotarget, and Tumor Biology, all in the United States. The top institution was Shanghai Jiao Tong University in China. The top author was Xipeng Wang. Co-occurrence analysis showed that academics\' interest is toward:1) 1) Exosomes as prognostic biomarkers of EOC as well as their role in the proliferation and migration of cells. 2) The role of exosomes in metastasis through different mechanisms; 3) The role of exosomes in epithelial-mesenchymal transition of
ovarian cancer cells; 4) The diagnostic role of EVs in EOC; and 5) Conferring chemoresistance in EOC through the exosomal transfer of miRNAs. Conclusion: Research on the exosome and EOC has an increasing trend, and China is much more involved than other countries in research, financial support, and international cooperation. These findings could aid researcher in understanding novel ideas and subjects interested by sponsors in this field.