PDF(Pubmed)
Abstract：
Thyroid hormones(THs) are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction. Autoimmune thyroid disease (AITD), one of the most common organ specific autoimmune diseases, is mainly mediated by cellular autoimmune reactions, and has strong inflammatory infiltration and immune active cells, including chemokines and cytokines, which are important components of ovarian aging. This suggests that autoimmune and inflammatory molecular processes may play a role in the emergence of ovarian dysfunction. The purpose of this review is to summarize recent in vivo and in vitro evidence of a complex relationship between AITD and ovarian dysfunction. AITD is closely related to the decline of ovarian function from the perspective of antibody, cytokine, oxidative stress, and genetic factors. Finally, some of the currently known treatments for AITD and hypo ovarian disease are summarized.
摘要：
甲状腺激素（THs）对于卵巢的正常运作至关重要，多项研究表明，甲状腺异常，特别是在青春期和生育年龄，可导致终身卵巢功能障碍。自身免疫性甲状腺疾病（AITD），最常见的器官特异性自身免疫性疾病之一，主要由细胞自身免疫反应介导，并有强烈的炎症浸润和免疫活性细胞，包括趋化因子和细胞因子,这是卵巢老化的重要组成部分。这表明自身免疫和炎症分子过程可能在卵巢功能障碍的出现中起作用。这篇综述的目的是总结AITD与卵巢功能障碍之间复杂关系的最新体内和体外证据。从抗体的角度来看,AITD与卵巢功能下降密切相关,细胞因子,氧化应激，和遗传因素。最后,总结了一些目前已知的AITD和低卵巢疾病的治疗方法。
