■描述关于急性淋巴细胞白血病ALL患者MBO口腔微生物组改变和OL口腔病变存在的现有知识。
■在PubMed中进行了电子搜索,SciELO,和学术谷歌数据库,和描述性的,分析,关于MBO的观察文章,OL,全部包括在内,遵循PRISMA标准。642人进行了评估,重复的文章,病例报告,和那些在化疗期间或之后仅报告变化的被删除。
■评估了10篇文章,在1997年至2021年间发表的4篇文章中,一致认为ALL患者的MBO处于菌群失调状态,显示出组织成分显著增加0.1%,芽孢杆菌0.05%,和机会性细菌,如莫拉氏菌属,克雷伯菌属5.66%,假单胞菌属3.77%,肠杆菌属1.88%,不动杆菌1.88%,大肠杆菌1.08%,5篇文章中最常见的OL是自发性牙龈出血3.5%,牙龈炎25%和溃疡9.4%。
■ALL患者的口腔处于菌群失调状态,并确定了相关的OL。有必要建立生态位生态方法的预防策略来恢复MBO,降低化疗期间机会性感染和其他OL的风险。
UNASSIGNED: To describe the existing knowledge about the alterations of the MBO oral microbiome and the presence of OL Oral Lesions in patients with Acute Lymphoblastic Leukemia ALL.
UNASSIGNED: An electronic search was carried out in the PubMed, SciELO, and academic Google databases, and descriptive, analytical, observational articles on MBO, OL, and ALL were included, following the PRISMA criteria. 642 were evaluated, duplicate articles, case reports, and those where only changes were reported during or after chemotherapy treatment were eliminated.
UNASSIGNED: 10 articles were evaluated, published between 1997 and 2021, 4 articles agreed that the MBO of patients with ALL is in dysbiosis showing a significant increase in firmicutes 0.1%, bacillus 0.05%, and opportunistic bacteria such as Moraxella spp, Klebsiella spp 5.66%, Pseudomonas spp 3.77%, Enterobacter spp 1.88%, Acinetobacter spp 1.88% and E. coli 1.08%, the most frequent OL reported in 5 articles were spontaneous gingival bleeding 3.5%, gingivitis 25% and ulcers 9.4%.
UNASSIGNED: The oral cavity of patients with ALL is in dysbiosis and associated OL is identified. It is necessary to establish preventive strategies with a niche-ecological approach to restore the MBO, to reduce the risk of opportunistic infections and other OL during chemotherapy treatment.