背景:静脉炎,一种罕见且致命的门静脉化脓性血栓性静脉炎,通常是由门静脉引流区域的感染引起的。在这里,我们报告一例急性严重阑尾炎导致门静脉血栓形成的腹膜炎,通过开放式腹腔管理(OAM)进行强化腹腔引流。
方法:一名19岁男性患有严重阑尾炎,肝脓肿,门静脉血栓形成发生感染性休克和多器官功能衰竭。紧急干预后,患者被送进重症监护室。基于显示多药耐药大肠杆菌和脆弱拟杆菌的培养物的抗生素治疗和抗凝治疗(使用肝素和依度沙班)开始。尽管持续的抗生素治疗,实验室结果一致显示炎症标志物水平升高.第13天,进行开放式腹腔冲洗以控制感染.广泛的肠水肿阻碍了伤口闭合,重症监护病房需要开腹管理。继续抗凝治疗,每5天进行一次腹腔冲洗。在第34天,使用腹直肌前鞘翻转方法实现伤口闭合。患者康复成功,第81天出院。
结论:除了适当的抗生素选择,早期手术引流和OAM是无价的。此病例强调了抗凝治疗在促进安全外科手术方面的潜力。
BACKGROUND: Pylephlebitis, a rare and lethal form of portal venous septic thrombophlebitis, often arises from infections in regions drained by the portal vein. Herein, we report a
case of peritonitis with portal vein thrombosis due to acute severe appendicitis, managed with intensive intraperitoneal drainage via open abdominal management (OAM).
METHODS: A 19-year-old male with severe appendicitis, liver abscesses, and portal vein thrombosis developed septic shock and multi-organ failure. After emergency interventions, the patient was admitted to the intensive care unit. Antibiotic treatment based on cultures revealing multidrug-resistant Escherichia coli and Bacteroides fragilis and anticoagulation therapy (using heparin and edoxaban) was initiated. Despite continuous antibiotic therapy, the laboratory results consistently showed elevated levels of inflammatory markers. On the 13th day, open abdominal irrigation was performed for infection control. Extensive intestinal edema precluded wound closure, necessitating open-abdominal management in the intensive care unit. Anticoagulation therapy was continued, and intra-abdominal washouts were performed every 5 days. On the 34th day, wound closure was achieved using the anterior rectus abdominis sheath turnover method. The patient recovered successfully and was discharged on the 81st day.
CONCLUSIONS: Alongside appropriate antibiotic selection, early surgical drainage and OAM are invaluable. This
case underscores the potential of anticoagulation therapy in facilitating safe surgical procedures.