Obstetric Labor Complications

产科分娩并发症
  • 文章类型: Journal Article
    背景:分娩准备和并发症准备是一种整体方法,赋予母亲和家庭以知识,态度,和资源来缓解分娩期间的潜在挑战。尽管有好处,丈夫参与孕产妇保健的国家和地区之间存在显著差异。以前的研究缺乏研究丈夫对分娩准备和并发症准备的反应。因此,这项研究的主要目标是找出有12个月以下婴儿的妻子的丈夫对分娩准备的感觉,为问题做好准备,及其相关因素。
    方法:2022年5月30日至7月29日进行了基于社区的横断面研究设计。采用简单随机抽样方法选择499名丈夫。一名面试官管理,结构化,并采用预测试问卷收集数据。分别使用Epi数据版本4.6和SPSS版本25进行数据输入和分析。我们使用多变量逻辑回归来寻找有统计学意义的因素。P值小于0.05,95%置信区间,和调整后的比值比用于声明统计显著性。调查结果如图所示,tables,和文本。
    结果:研究发现,55.9%(95%CI:51.4%至61.4%)的丈夫对分娩准备和并发症准备有反应。该反应与被雇用显着相关(AOR=3.7,95%CI:2.27-5.95),从事自营业务(AOR=5.3,95%CI:2.34-12.01),有在医疗机构分娩的妻子(AOR=7.1,95%CI:3.92-12.86),陪伴妻子进行产前护理(AOR=2.2,95%CI:1.39-3.56),在分娩期间(AOR=2.0,95%CI:1.08-3.74)和产后(AOR=7.1,95%CI:3.14-16.01)具有良好的危险体征知识。有趣的是,居住在医疗机构附近的居民(AOR=0.6,95%CI:0.39-0.97)反应的可能性较小.
    结论:本研究发现,近6/10的丈夫在分娩准备和并发症准备方面积极回应。虽然这项研究中的丈夫在分娩准备和并发症方面表现出一些参与,与在全国范围内进行的研究相比,这是很好的。为了改善这一点,建议通过关注危险信号及其在分娩中的作用来教育丈夫。
    BACKGROUND: Birth preparedness and complication readiness is a holistic approach that empowers mothers and families with the knowledge, attitude, and resources to alleviate potential challenges during childbirth. Despite its benefits, husbands\' participation in maternal care differs significantly between countries and regions. There is a lack of previous studies that look at husbands\' responses to birth preparedness and complication readiness in the research area. Thus, the primary goal of this study is to find out how husbands who have wives with infants under 12 months old feel about birth preparation, readiness for problems, and its associated factors.
    METHODS: A community-based cross-sectional study design was conducted from May 30 to July 29, 2022. Simple random sampling was employed to select 499 husbands. An interviewer-administered, structured, and pretested questionnaire was used to collect the data. Data entry and analysis were performed using Epi Data version 4.6 and SPSS version 25, respectively. We used multivariable logistic regression to find statistically significant factors. P-values less than 0.05, 95% confidence intervals, and adjusted odds ratios are used to declare statistical significance. The findings were shown in figures, tables, and text.
    RESULTS: The study found that 55.9% (95% CI: 51.4 to 61.4%) of husbands responded to birth preparedness and complication readiness. This response was significantly associated with being employed (AOR = 3.7, 95% CI: 2.27-5.95), engaging in self-business (AOR = 5.3, 95% CI: 2.34-12.01), having wives who delivered in health facilities (AOR = 7.1, 95% CI: 3.92-12.86), accompanying wives for antenatal care (AOR = 2.2, 95% CI: 1.39-3.56), possessing good knowledge of danger signs during labor (AOR = 2.0, 95% CI: 1.08-3.74) and the postnatal period (AOR = 7.1, 95% CI: 3.14-16.01). Interestingly, residents living near a health facility (AOR = 0.6, 95% CI: 0.39-0.97) were less likely to respond.
    CONCLUSIONS: The present study found that nearly 6 out of 10 husbands actively responded in terms of birth preparedness and complication readiness. While husbands in this study showed some involvement in birth preparedness and complications, it is good when compared to studies carried out nationally. To improve this, educating husbands by focusing on the danger signs and their role in childbirth is recommended.
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  • 文章类型: Journal Article
    目的:无潜在血管畸形或易感的非创伤性眼眶出血并不常见,在产妇分娩的情况下尤其罕见。本研究结合了新颖的病例报告和回顾性审查,以分析报告的病例并提出见解。
    方法:本研究既是一个独特的案例报告,也是研究PubMed出版物的文献综述,通过引用将文章追溯到原始来源进行收录。分析包括临床表现,目视检查,血肿特征,神经影像学,管理策略,和结果。
    结果:我们介绍了一名37岁的多胎女性,在妊娠40周时出现了急性右侧突出,复视,球后疼痛,第二产程中眶周水肿。计算机断层扫描(CT)显示骨膜下出血,随后磁共振成像(MRI)排除血管异常。症状在两个月内缓解。仅报告了14例与分娩相关的母体眼眶血肿。平均年龄为28岁,其中42%(6/14)是初等年龄。包括我们的案子,40%(6/15)在第二产程出现症状,40%(6/15)产后立即,20%(3/15)产后24小时以上。总的来说,33%(5/15)有潜在的促成条件,包括凝血功能障碍,分娩并发症,或者血管畸形.单侧眼眶出血发生率为87%(13/15)。13%(2/15)需要手术干预。大多数(87%,13/15)接受观察或医疗管理,症状完全恢复。
    结论:与产妇分娩相关的非创伤性眼眶血肿是罕见的,可能与分娩时的valsalva增加和妊娠时的血容量增加有关。建议进行神经成像和全身检查以评估血管异常或潜在的凝血病。总体预后良好,大多数患者完全康复。
    OBJECTIVE: Non-traumatic orbital hemorrhage without underlying vascular malformations or predisposing conditions is uncommon, and particularly rare in the context of maternal labor. This study combines a novel case report and retrospective review to analyze reported cases and propose insights.
    METHODS: This study is both a unique case report and literature review examining PubMed publications with articles traced back to original sources through citations for inclusion. Analysis included clinical presentation, visual examination, hematoma characteristics, neuroimaging, management strategies, and outcomes.
    RESULTS: We present a 37-year-old multigravida woman at 40 weeks gestation who developed acute right-sided proptosis, diplopia, retrobulbar pain, and periorbital edema during the second stage of labor. Computed tomography (CT) revealed a subperiosteal hemorrhage, with subsequent magnetic resonance imaging (MRI) excluding vascular anomalies. Symptoms resolved within two months. Only 14 cases of maternal orbital hematoma associated with labor have been reported. The average age was 28 with 42% (6/14) being primigravid. Including our case, forty percent (6/15) developed symptoms during the second stage of labor, 40% (6/15) immediately postpartum, and 20% (3/15) over 24 hours postpartum. Overall, 33% (5/15) had potentially contributing conditions including coagulopathies, delivery complications, or vascular malformations. Unilateral orbital hemorrhage occurred in 87% (13/15). Surgical intervention was necessary in 13% (2/15). Most (87%, 13/15) underwent observation or medical management with full recovery of symptoms.
    CONCLUSIONS: Non-traumatic orbital hematomas associated with maternal labor are rare and likely related to increased valsalva during delivery and heightened blood volume in pregnancy. Neuro-imaging and systemic workup are recommended to assess for vascular anomalies or underlying coagulopathies. The overall prognosis is favorable with most having full recovery.
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    文章类型: Journal Article
    早产被描述为在怀孕37周结束前活着出生的婴儿。每年约有1500万婴儿早产,100多万婴儿因并发症死亡。在发展中国家,像埃塞俄比亚一样,PTB被低估和低估。目标-确定在FelegeHiwot综合专业转诊医院分娩的母亲中早产的决定因素,埃塞俄比亚西北部。进行了不匹配的病例对照研究设计。总样本量为558名母亲140例和418名对照。使用简单随机抽样来选择研究人群。数据被编码并输入Epidata,版本3.2,并使用STATA版本14进行了分析。有产前出血病史的母亲(AOR3.53,95%CI1.31-9.47),胎膜早破(AOR8.9,95%CI4.51-17.57),妊娠高血压(AOR3.65,95%CI1.78-7.51),多胎妊娠史(AOR2.49,95%CI0.89-6.95),初产妇(AOR0.16,95%CI0.03-0.97)和初产妇(AOR0.054,95%CI0.05-0.64)与早产有统计学显著关联.产前出血妇女早产的几率较高,PIH,PROM,和多胎妊娠,但在初产妇和初产妇中更低。
    Preterm birth is described as babies that are born alive before the end of 37 weeks of pregnancy. About 15 million babies are born preterm annually and more than a million died due to complications. In developing nations, like Ethiopia, PTB is underreported and underestimated. Objective - to identify determinates of preterm birth among mothers who gave birth at Felege Hiwot Comprehensive Specialized Referral Hospital, Northwest Ethiopia. Unmatched case-control study design was conducted. The total sample size was 558 mothers 140 cases and 418 controls. Simple random sampling was used to select the study population. Data were coded and entered into Epidata, version 3.2, and was analyzed by using STATA version 14. Mothers with a history of antepartum hemorrhage (AOR 3.53, 95% CI 1.31-9.47), premature rupture of membrane (AOR 8.9, 95% CI 4.51-17.57), pregnancy-induced hypertension (AOR 3.65, 95% CI 1.78-7.51), history of multiple pregnancies (AOR 2.49, 95% CI 0.89-6.95), primigravida (AOR 0.16, 95% CI 0.03-0.97) and Primiparity(AOR 0.054, 95% CI 0.05-0.64) had statistically significant association with experiencing preterm birth. The odds of giving preterm birth were higher among women with antepartum hemorrhage, PIH, PROM, and multiple pregnancies, but lower among primigravida and primiparous mothers.
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  • 文章类型: Journal Article
    加纳大阿克拉地区(GAR)每年记录2000例死胎,其中40%发生在产时。对影响因素的了解将有助于制定预防策略,以减少大量的产期死胎。这项研究确定了GAR产时死胎的决定因素。在加纳大阿克拉地区的六家公立医院进行了1:2的回顾性病例对照研究。使用多变量二元逻辑回归模型来量化暴露对产时死胎的影响。使用受试者工作特征曲线下的面积和Brier得分来筛选潜在的风险因素并评估回归模型的预测性能。以下母体因素增加了产时死胎的几率:妊娠高血压(PIH)[调整后的几率;aOR=3.72,95%CI:1.71-8.10,p<0.001];产前出血(APH)[aOR=3.28,95%CI:1.33-8.10,p<0.05]和胎膜早破(PROM)[aOR=3.36,9.40,pCI]:改善PIH的管理,APH,PROM,早产将减少产时死产。医院应提高产妇产程监测质量。所有医院都必须对产时死产进行审核,加纳卫生局应在死产审核中包括胎儿尸检,以确定胎儿死亡的其他原因。减少产时死产的干预措施必须结合产妇,胎儿和服务分娩因素,使其有效。
    The Greater Accra Region (GAR) of Ghana records 2000 stillbirths annually and 40% of them occur intrapartum. An understanding of the contributing factors will facilitate the development of preventive strategies to reduce the huge numbers of intrapartum stillbirths. This study identified determinants of intrapartum stillbirths in GAR. A retrospective 1:2 unmatched case-control study was conducted in six public hospitals in the Greater Accra Region of Ghana. A multivariable binary logistic regression model was used to quantify the effect of exposures on intrapartum stillbirth. The area under the receiver operating characteristics curve and the Brier scores were used to screen potential risk factors and assess the predictive performance of the regression models. The following maternal factors increased the odds of intrapartum stillbirths: pregnancy-induced hypertension (PIH) [adjusted Odds Ratio; aOR = 3.72, 95% CI:1.71-8.10, p < 0.001]; antepartum haemorrhage (APH) [aOR = 3.28, 95% CI: 1.33-8.10, p < 0.05] and premature rupture of membranes (PROM) [aOR = 3.36, 95% CI: 1.20-9.40, p < 0.05]. Improved management of PIH, APH, PROM, and preterm delivery will reduce intrapartum stillbirth. Hospitals should improve on the quality of monitoring women during labor. Auditing of intrapartum stillbirths should be mandatory for all hospitals and Ghana Health Service should include fetal autopsy in stillbirth auditing to identify other causes of fetal deaths. Interventions to reduce intrapartum stillbirth must combine maternal, fetal and service delivery factors to make them effective.
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  • 文章类型: Review
    背景:孤立的直肠扣眼撕裂是一种罕见的产科并发症,因此对其治疗缺乏共识。当前的病例系列回顾了有关产科直肠纽扣孔损伤的已发表文献,并提供了我们机构的进一步病例。
    方法:进行了文献综述,并对所有结果进行了综述。在我们机构中,在2012年至2022年间阴道分娩后的直肠钮孔撕裂被确定。记录修复技术和术后处理。
    结果:共有14例已发表病例报告。七个病例报告描述了两层封闭,和七份报告描述了一个三层封闭。与结直肠外科医生合作修复了4例。12例6周后无症状。一名妇女在伤口破裂后造口失效,一名妇女因直肠出血再次入院。我们在我们的机构中发现了两名扣眼眼泪的女性。在这两种情况下都进行了三层修复,每位妇女都得到了顺利的恢复。
    结论:直肠扣眼撕裂的修复技术因机构而异。尽管有这种差异,大多数女性在这些伤害后没有短期发病。这篇综述增加了当前文献的不同修复技术和结果的例子。
    BACKGROUND: Isolated rectal buttonhole tears are a rare obstetric complication and so there is a lack of consensus for their management. The current case series reviews the published literature on obstetric rectal buttonhole injuries and provides further cases from our institution.
    METHODS: A literature review was performed and all results were reviewed. Rectal buttonhole tears following vaginal delivery between 2012 and 2022 in our institution were identified. Repair technique and postoperative management were recorded.
    RESULTS: There were 14 published case reports. Seven case reports described a two-layer closure, and seven reports described a three-layer closure. Four cases were repaired in collaboration with colorectal surgeons. Twelve cases were asymptomatic after 6 weeks. One woman had a defunctioning stoma following a wound breakdown and one woman was readmitted with a rectal hemorrhage. We identified two women in our institution with buttonhole tears. Three-layer repairs were performed in both cases and each woman made an uneventful recovery.
    CONCLUSIONS: Repair techniques of rectal buttonhole tears vary among institutions. Despite this variance, most women experience no short-term morbidity following these injuries. This review adds to the current literature with examples of different repair techniques and outcomes.
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  • 文章类型: Case Reports
    子宫倒置是一种罕见的产后并发症。这是一种罕见的情况,其中子宫的内表面突出通过阴道。非产褥期子宫内翻(NPUI)极为罕见。在大多数情况下,它与子宫肿瘤有关。在这些肿瘤中,据报道,平滑肌瘤是最常见的病因。这种情况在手术之前可能不会被注意到。在大多数情况下怀疑恶性肿瘤。然而,术前可以使用放射学诊断子宫内翻。诊断NPUI的困难使该临床病例成为妇科的挑战,在文献中并不常见。我们报告了与子宫血管平滑肌瘤相关的完全非产褥期子宫内翻的诊断和治疗经验。患者年龄为44岁,Gravida2para1出现间歇性阴道出血四个月和急性腹部绞痛疼痛。在检查中,观察到大的肿块病变占据了阴道腔,无法达到子宫颈的轮廓。活检和免疫组织化学与血管平滑肌瘤匹配。她接受了经阴道手术复位技术:Spinelli's。准确诊断非产褥期子宫内翻非常重要。手术提供良好的预后,这是必要的。我们报告一例血管平滑肌瘤引起的NPUI。然而,必须首先消除恶性肿瘤。
    Uterine inversion is a rare postpartum complication. It is a rare condition in which the internal surface of the uterus protrudes through the vagina. Non-puerperal uterine inversion (NPUI) is extremely rare. In most instances, it is linked to uterine tumors. Among these tumors, leiomyoma is the most frequent cause reported in data. This condition may not be noticed until time of surgery. Malignancy is suspected in most cases. Nevertheless, uterine inversion can be diagnosed preoperatively using radiology. Difficulties in diagnosing NPUI makes this clinical case a challenge in gynaecology and not commonly reported in literature. We report our experience in the diagnosis and treatment of a complete non-puerperal uterine inversion associated with uterine angioleiomyoma. The patient\'s age was 44, gravida 2 para 1 presented with intermittent vaginal bleeding for four months and an acute abdominal cramping pain. On examination, a large mass lesion was observed which occupies the vaginal cavity and the contour of the uterine cervix could not be reached. Biopsies and Immunohistochemistry matched with an angioleiomyoma. She underwent a transvaginal surgical reposition technique: Spinelli\'s. It is important to diagnose accurate non-puerperal uterine inversion. Surgery provides good prognosis and it is necessary. We report a case of NPUI caused by angioleiomyoma. Nevertheless, malignancy must be eliminated in first place.
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  • 文章类型: Journal Article
    背景:Apgar评分用于评估新生儿的总体状况和复苏反应,以及它在新生儿期之后的预后。低的第5分钟Apgar评分更为频繁,并且与新生儿死亡率和发病率的风险显着增加有关。在埃塞俄比亚,出生窒息的患病率很高(22.52%)。出生窒息导致新生儿严重缺氧缺血性多器官损害,主要是脑损伤。因此,本研究旨在确定剖宫产分娩新生儿中5分钟Apgar评分低的决定因素.
    方法:进行了无匹配的病例对照研究设计。阿普加评分是基于心率的测量,呼吸努力,肤色,肌肉张力,和反射性烦躁。数据收集工具或检查表改编自先前在亚的斯亚贝巴进行的研究,埃塞俄比亚。在这项研究中,病例均为Apgar评分<7的新生儿,而对照组均为Apgar评分>=7的新生儿。通过简单随机抽样技术选择研究参与者。数据进入Epidata版本4.6并导出到SPSS软件版本24。采用多变量logistic回归分析各因素在P<0.05时的独立作用。
    结果:与低Apgar评分相关的因素是胎儿出生体重<2.5kg[调整后的比值比(AOR)=8.17,95%置信区间(CI):1.03-64.59]P=0.046,皮肤切口至分娩时间(AOR=5.27;95-CI:2.20-12.60)P=0.001,妊娠高血压(AOR=4.58%,95%
    结论:胎儿出生体重<2.5公斤,皮肤切口到分娩时间,妊娠高血压,产前出血,麻醉类型,羊水粪染和剖宫产类型是Apgar评分的独立相关因素。因此,重要的是要研究已确定的风险因素,以减少成年早期第5分钟Apgar评分较低的影响。.
    BACKGROUND: Apgar score is used to evaluate the neonates\' overall status and response to resuscitation, as well as its prognosis beyond the neonatal period. Low fifth minute Apgar scores is more frequent and is associated with markedly increased risks of neonatal mortality and morbidity. In Ethiopia, the prevalence of birth asphyxia is high (22.52%). Birth asphyxia contributes to significant neonatal morbidities and mortalities due to severe hypoxic-ischemic multi-organ damage, mainly brain damage. Therefore, this study was aimed to identify determinants of low fifth minute Apgar score among newborns delivered by cesarean section.
    METHODS: An unmatched case control study design was conducted. The Apgar score is based on measures of heart rate, respiratory effort, skin color, muscle tone, and reflex irritability. The data collection tool or checklist was adapted from previous study done at Addis Ababa, Ethiopia. In this study, cases were all newborns with Apgar score < 7 whereas controls were all newborns with Apgar score >  = 7. The study participants were selected by simple random sampling technique. Data was into Epidata version 4.6 and exported to SPSS software version 24. Multivariable logistic regression was used to identify the independent effect of different factors at P < 0.05.
    RESULTS: Factors associated with low Apgar score were fetal birth weight < 2.5 kg [adjusted odds ratio (AOR) = 8.17, 95% confidence interval (CI): 1.03 ‒ 64.59] P = 0.046, skin incision to delivery time (AOR = 5.27; 95% CI: 2.20 ‒ 12.60) P = 0.001, pregnancy induced hypertension (AOR = 4.58, 95% CI: 1.75 ‒ 11.92) P = 0.002, antepartum hemorrhage (AOR = 3.96; 95% CI: 1.75 ‒ 8.94) 0.001, general anesthesia (AOR = 3.37, 95% CI: 1.72 ‒ 6.62) P = 0.001, meconium stained amniotic fluid (AOR = 3.07, 95% CI: 1.32 ‒ 7.12) P = 0.009 and emergency cesarean section (AOR = 2.17, 95% CI: 1.13 ‒ 4.15) P = 0.019.
    CONCLUSIONS: Fetal birth weight < 2.5 kg, skin incision to delivery time, pregnancy induced hypertension, antepartum hemorrhage, type of anesthesia, meconium stained amniotic fluid and type of cesarean section were factors independently associated with Apgar score. Therefore, it is important to work on identified risk factors to reduce the impacts low fifth minute Apgar score in the in early adulthood..
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  • 文章类型: Journal Article
    背景:产科肛门括约肌损伤(OASI)是阴道分娩的常见和严重并发症,可能具有短期和长期后果,包括肛门失禁,性功能障碍和生活质量下降。OASI的比率在研究和国家出生统计数据之间差异很大,最近的一项荟萃分析得出结论,有必要识别未识别的风险因素。因此,我们的目标是探索OASI的潜在可修改和不可修改的风险因素。
    方法:我们在挪威东南部的单中心产科诊所进行了病例对照研究。数据是从机构出生登记处回顾性提取的。主要结局指标是妊娠30周后单胎阴道分娩后妇女首次发生3度或4度会阴病变(OASI)。对于每位患有OASI的女性,随后的第一个与产次匹配的阴道单胎分娩被选为对照。研究人群包括421名OASI妇女和421名匹配的对照组,她们在1990-2002年期间分娩。通过条件逻辑回归分析评估了OASI的潜在危险因素。
    结果:OASI的平均发生率为阴道分娩的3.4%,但在研究期间,这一比例从1.9%上升到5.8%。在最终的多元回归模型中,初产妇的母亲年龄和出生体重较高,多胎妇女的出生体重更高,是与OASI相关的唯一不可修改的变量。在初产妇(比值比[OR]4.84;95%置信区间[CI]2.60-9.02)和经产妇(OR3.76;95%CI1.45-9.76)中,羊膜切开术是OASI的最强可改变风险因素,其次是催产素增强(初产:OR1.63;95%CI1.08-2.46,经产:OR3.70;95%CI1.79-7.67)。真空抽取和产钳分娩仅是初产妇的重要危险因素(真空:OR1.91;95%CI1.03-3.57,产钳:OR2.37;95%CI1.14-4.92),经产妇女的会阴切开术(OR2.64;95%CI1.36-5.14)。
    结论:羊膜切开术可能是OASI的一个未被认可的独立可改变的危险因素,应进一步研究其在预防策略中的潜在作用。
    BACKGROUND: Obstetric anal sphincter injury (OASI) is a common and severe complication of vaginal delivery and may have short- and long-term consequences, including anal incontinence, sexual dysfunction and reduced quality of life. The rate of OASI varies substantially between studies and national birth statistics, and a recent meta-analysis concluded that there is a need to identify unrecognized risk factors. Our aim was therefore to explore both potential modifiable and non-modifiable risk factors for OASI.
    METHODS: We performed a case-control study in a single center maternity clinic in South-Eastern Norway. Data were extracted retrospectively from an institutional birth registry. The main outcome measure was the occurrence of the woman\'s first-time 3rd or 4th degree perineal lesion (OASI) following singleton vaginal birth after 30 weeks\' gestation. For each woman with OASI the first subsequent vaginal singleton delivery matched for parity was elected as control. The study population included 421 women with OASI and 421 matched controls who gave birth during 1990-2002. Potential risk factors for OASI were assessed by conditional logistic regression analyses.
    RESULTS: The mean incidence of OASI was 3.4% of vaginal deliveries, but it increased from 1.9% to 5.8% during the study period. In the final multivariate regression model, higher maternal age and birthweight for primiparous women, and higher birthweight for the multiparous women, were the only non-modifiable variables associated with OASI. Amniotomy was the strongest modifiable risk factor for OASI in both primi- (odds ratio [OR] 4.84; 95% confidence interval [CI] 2.60-9.02) and multiparous (OR 3.76; 95% CI 1.45-9.76) women, followed by augmentation with oxytocin (primiparous: OR 1.63; 95% CI 1.08-2.46, multiparous: OR 3.70; 95% CI 1.79-7.67). Vacuum extraction and forceps delivery were only significant risk factors in primiparous women (vacuum: OR 1.91; 95% CI 1.03-3.57, forceps: OR 2.37; 95% CI 1.14-4.92), and episiotomy in multiparous women (OR 2.64; 95% CI 1.36-5.14).
    CONCLUSIONS: Amniotomy may be an unrecognized independent modifiable risk factor for OASI and should be further investigated for its potential role in preventive strategies.
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  • 文章类型: Journal Article
    非感染性炎症已被认为是硬膜外相关产妇发热的主要原因。我们假设入院时母体血清C反应蛋白(CRP)和白细胞(WBC)计数可预测产妇产时发热。
    2019年在三级医院接受阴道分娩的低风险妇女的回顾性病例对照研究。包括足月单胎妊娠和头颅表现的妇女,她们接受硬膜外分娩镇痛并出现产时发热(≥38.0°C)。与胎次和胎龄相匹配的对照组接受了硬膜外镇痛,但没有发烧。通过多变量logistic回归分析评估孕妇CRP水平和发热入院时白细胞计数的相关性。通过受试者工作特征(ROC)曲线评估两种标志物对发烧的预测性能。
    总的来说,687名妇女符合纳入标准,687名妇女作为对照。发热妇女入院时的WBC计数高于发热妇女(8.7vs.8.5×109/L,P=0.001),并且与发烧中度相关(最高四分位数内的女性与最低的四分位数,调整后的赔率比1.92;95%置信区间[CI]1.34至2.75),但对发热的预测能力较低(ROC曲线下面积0.55,95%CI0.52~0.58).入院CRP值与发热无关。当按入院时的劳动状况分层时,WBC计数与发热的关联仅在非劳动妇女中存在.
    产妇入院时血清CRP和WBC不能预测分娩时硬膜外分娩镇痛妇女的产时发热。
    Non-infectious inflammation has been proposed as a major contributor to epidural-related maternal fever. We hypothesized that maternal serum C-reactive protein (CRP) and white blood cell (WBC) count at hospital admission predict intrapartum maternal fever.
    A retrospective case-control study of low-risk women admitted for vaginal deliveries at a tertiary hospital in 2019. Women with a singleton pregnancy at term and a cephalic presentation who received epidural labor analgesia and developed intrapartum fever (≥38.0°C) were included. Controls matched by parity and gestational age received epidural analgesia without fever. The associations of maternal CRP level and WBC count on admission with fever were evaluated by a multivariable logistic regression analysis. The predictive performances of both markers for fever were evaluated by receiver-operating characteristic (ROC) curves.
    Overall, 687 women met the inclusion criteria and 687 served as controls. The WBC count on admission was higher in febrile than in afebrile women (8.7 vs. 8.5 × 109/L, P=0.001) and was moderately associated with fever (women within the highest quartile vs. the lowest quartile, adjusted odds ratio 1.92; 95% confidence interval [CI] 1.34 to 2.75), but the predictive performance for fever was low (area under the ROC curve 0.55, 95% CI 0.52 to 0.58). Admission CRP values were not associated with fever. When stratified by labor status on admission, the association of WBC count with fever was only in non-laboring women.
    Maternal serum CRP and WBC at hospital admission do not predict intrapartum fever in women having epidural labor analgesia at term.
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  • 文章类型: Journal Article
    背景:产科瘘(OF)是低资源环境中产妇发病率的重要原因,在这种环境中,妇女在无法及时获得熟练产科护理的情况下经历难产。OF的真正流行是未知的;然而,据估计,这将影响全球200万至350万妇女。人口和健康调查(DHS)瘘模块包括最常用于患病率估计的OF症状问题,但是这些问题还没有得到验证。这项研究的目的是验证基于症状的筛查问卷,包括国土安全部瘘模块中的一个问题。
    方法:与一个国际瘘管外科专家小组合作,我们开发并面部验证了筛查问卷,评估下尿路瘘(LUTF)和下胃肠道瘘(LGTF)的症状,以及尿失禁和大便失禁(UI,FI).我们使用1:2:2比例的病例对照研究设计评估了问卷的辨别能力:病例为检查证实为瘘管的产妇,对照组包括检查时没有瘘管的产妇,有和没有UI症状。所有妇女都接受了瘘管症状筛查和体格检查,审查员对筛查结果视而不见。
    结果:在完成问卷并接受临床检查的367名卢旺达妇女中,59名妇女患有LUTF,34名妇女患有LGTF,274名女性被归类为有和没有UI症状的对照。所有LUTF筛选问题都表现良好,包括国土安全部的瘘管问题.两个LUTF筛查问题的组合具有最高的敏感性(100%;95%CI94%,100%),特异性(96%;95%CI93%,98%),和曲线下面积(AUC)(0.98)。LGTF筛查问题和FI问题的组合显示出最高的敏感性(97%;95%CI85%,100%),特异性(98%;95%CI95%,99%)和AUC(0.98)。
    结论:我们的筛选问卷,包括国土安全部的瘘管问题,表现出高度的敏感性,特殊性,AUC。
    产科瘘(OF)是一种产伤,可能发生在资源较低的妇女中,她们在没有熟练产科护理的情况下经历了难产(不正常进展)。这种伤害导致妇女不断地从她的产道中泄漏尿液和/或粪便。由于OF影响远离医疗保健的贫困妇女,很难完全理解全球有多少妇女患有OF。此外,尽管一些人口和健康调查(DHS)包括症状问题,这些问题在确定女性患有OF时的准确性尚未得到研究。为了更准确地确定哪些女性可能患有OF,我们在咨询了世界各地的专家后制定了一份OF筛查问卷,其中包括一个国土安全部的问题。我们向卢旺达的妇女询问了这份问卷,然后检查了这些妇女,看看她们是否有OF。通过这个过程,我们确定了59名患有LUTF的女性,34带有LGTF,274没有OF。表现最好的问题能够识别出100%的LUTF女性和97%的LGTF女性。我们还表明,一个DHS问题100%和85%的时间检测到LUTF和LGTF的女性,分别。公共卫生官员现在可以使用我们研究的问题来更准确地估计全球有多少女性患有OF,和最好的直接资源和熟练的卫生保健工作者到最需要的地区。
    BACKGROUND: Obstetric fistula (OF) is a significant cause of maternal morbidity in lower resource settings where women experience obstructed labor without timely access to skilled obstetric care. The true prevalence of OF is unknown; however, it is estimated to affect 2 to 3.5 million women globally. The Demographic and Health Surveys\' (DHS) Fistula Module includes the OF symptom questions most frequently used for prevalence estimates, but these questions have not been validated. The aim of this study is to validate a symptom-based screening questionnaire for OF, including a question in the DHS\' Fistula Module.
    METHODS: With an international panel of fistula surgeons, we developed and face-validated a screening questionnaire that assessed for symptoms of lower urinary tract fistula (LUTF) and lower gastrointestinal tract fistula (LGTF), as well as urinary and fecal incontinence (UI, FI). We evaluated the discriminative ability of the questionnaire using a case-control study design in a 1:2:2 ratio: cases were parous women with fistula confirmed on examination, controls included parous women without fistula on examination, with and without UI symptoms. All women underwent screening for fistula symptoms and a physical examination, with examiners blinded to screening results.
    RESULTS: Of the 367 Rwandan women who completed the questionnaires and underwent clinical examination, 59 women had LUTFs and 34 had LGTFs, 274 women were classified as controls with and without symptoms of UI. All LUTF screening questions performed well, including the DHS fistula question. The combination of two LUTF screening questions had the highest sensitivity (100%; 95% CI 94%, 100%), specificity (96%; 95% CI 93%, 98%), and area under the curve (AUC) (0.98). The combination of a LGTF screening question and FI question demonstrated the highest sensitivity (97%; 95% CI 85%, 100%), specificity (98%; 95% CI 95%, 99%) and AUC (0.98).
    CONCLUSIONS: Our OF screening questionnaire, including the DHS fistula question, demonstrated high sensitivities, specificities, and AUC.
    Obstetric fistula (OF) is a birth injury which may occur in women living in lower resource settings who experience obstructed labor (not progressing normally) without access to skilled obstetric care. This injury causes a woman to constantly leak urine and/or feces from her birth canal. As OF affects poor women who live far from healthcare it is difficult to fully understand how many women worldwide have an OF. Furthermore, although some Demographic and Health Surveys (DHS) include OF symptom questions, the accuracy of these questions in identifying women with OF has not been studied.To more accurately determine which women may have an OF, we developed an OF screening questionnaire after consulting OF experts worldwide, which included a DHS OF question. We asked women from Rwanda this questionnaire and then examined these women to see if they have OF. Through this process we identified 59 women with a LUTF, 34 with a LGTF, and 274 without an OF. The best performing questions were able to identify women with LUTF 100% of the time and women with LGTF 97% of the time. We also showed that one DHS question detects women with LUTF and LGTF 100% and 85% of the time, respectively. Public health officials can now use the questions we studied to more accurately estimate how many women worldwide have OF, and best direct resources and skilled health care workers to the areas with the greatest need.
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