目的:使用OCT血管造影术(OCTA)描述黄斑视网膜血管系统的规范定量参数及其系统和眼部关联。
方法:以人口为基础,横断面研究。
方法:从基于人群的新加坡马来人眼科研究的第三次检查中招募年龄>50岁的成年人。
方法:所有参与者都接受了黄斑的标准化综合检查和谱域OCTA(Optovue)。OCT血管造影扫描显示预先存在的视网膜疾病,显示黄斑病变,质量差的被排除在外。
方法:表面层的规范定量血管密度,深层,和中央凹无血管区(FAZ)进行评估。在多变量分析中,还使用线性回归模型和广义估计方程模型评估了眼部和全身与黄斑视网膜血管参数的关联。
结果:我们纳入了749名参与者的1184次扫描(1184只眼)。平均黄斑浅表血管密度(SVD)和深血管密度(DVD)为45.1±4.2%(95%置信区间[CI],37.8%-51.4%)和44.4±5.2%(95%CI,36.9%-53.2%),分别。平均SVD和DVD在上象限(48.7±5.9%)和鼻象限(52.7±4.6%)中最高,分别。平均FAZ面积和周长分别为0.32±0.11mm2(95%CI,0.17-0.51mm)和2.14±0.38mm(95%CI,1.54-2.75mm),分别。在多元回归分析中,女性与较高的SVD(β=1.25,P≤0.001)和DVD(β=0.75,P=0.021)相关。年龄较大(β=-0.67,P<0.001)与较低的SVD相关,而较长的轴向长度(β=-0.42,P=0.003)与较低的DVD相关。女性性别,较短的轴向长度,最佳矫正视力较差与较大的FAZ面积相关。未发现一系列系统参数与血管密度的关联。
结论:这项研究提供了亚洲成年人群的规范黄斑血管参数,这可以作为正常和疾病状态下OCTA数据定量解释的参考值。
OBJECTIVE: To describe the normative quantitative parameters of the macular retinal vasculature as well as their systemic and ocular associations using OCT angiography (OCTA).
METHODS: Population-based, cross-sectional
study.
METHODS: Adults aged > 50 years were recruited from the third examination of the population-based Singapore Malay Eye
Study.
METHODS: All participants underwent a standardized comprehensive examination and spectral-domain OCTA (Optovue) of the macula. OCT angiography scans that revealed pre-existing retinal disease, revealed macular pathology, and had poor quality were excluded.
METHODS: The normative quantitative vessel densities of the superficial layer, deep layer, and foveal avascular zone (FAZ) were evaluated. Ocular and systemic associations with macular retinal vasculature parameters were also evaluated in a multivariable analysis using linear regression models with generalized estimating equation models.
RESULTS: We included 1184 scans (1184 eyes) of 749 participants. The mean macular superficial vessel density (SVD) and deep vessel density (DVD) were 45.1 ± 4.2% (95% confidence interval [CI], 37.8%-51.4%) and 44.4 ± 5.2% (95% CI, 36.9%-53.2%), respectively. The mean SVD and DVD were highest in the superior quadrant (48.7 ± 5.9%) and nasal quadrant (52.7 ± 4.6%), respectively. The mean FAZ area and perimeter were 0.32 ± 0.11 mm2 (95% CI, 0.17-0.51 mm) and 2.14 ± 0.38 mm (95% CI, 1.54-2.75 mm), respectively. In the multivariable regression analysis, female sex was associated with higher SVD (β = 1.25, P ≤ 0.001) and DVD (β = 0.75, P = 0.021). Older age (β = -0.67, P < 0.001) was associated with lower SVD, whereas longer axial length (β = -0.42, P = 0.003) was associated with lower DVD. Female sex, shorter axial length, and worse best-corrected distance visual acuity were associated with a larger FAZ area. No association of a range of systemic parameters with vessel density was found.
CONCLUSIONS: This
study provided normative macular vasculature parameters in an adult Asian population, which may serve as reference values for quantitative interpretation of OCTA data in normal and disease states.