PDF(Pubmed)
Abstract：
UNASSIGNED: To evaluate differences in the retinal microvasculature and structure and choroidal structure among men and women with Alzheimer\'s disease (AD) compared with age-matched cognitively normal male and female controls.
UNASSIGNED: Case-control study of participants ≥ 50 years of age.
UNASSIGNED: A total of 202 eyes of 139 subjects (101 cases and 101 controls).
UNASSIGNED: All participants and controls underwent OCT and OCT angiography (OCTA), and parameters of subjects with AD were compared with those of cognitively normal controls.
UNASSIGNED: The foveal avascular zone (FAZ) area, vessel density (VD), and perfusion density (PD) in the superficial capillary plexus within the 3- and 6-mm circle and ring using Early Treatment Diabetic Retinopathy Study (ETDRS) grid overlay on OCTA; central subfield thickness (CST), retinal nerve fiber layer (RNFL) thickness, ganglion cell-inner plexiform layer (GCIPL) thickness, and choroidal vascularity index (CVI) on OCT.
UNASSIGNED: No significant sex differences in VD or PD were found in the AD or control cohorts; however, there were greater differences in VD and PD among AD female participants than AD male participants compared with their respective controls. The CST and FAZ area were not different between male and female AD participants. Among controls, men had a thicker CST (P < 0.001) and smaller FAZ area (P = 0.003) compared with women. The RNFL thickness, GCIPL thickness, and CVI were similar among male and female AD participants and controls.
UNASSIGNED: There may be a loss of the physiologic sex-related differences in retinal structure and microvasculature in those with AD compared with controls. Further studies are needed to elucidate the pathophysiological basis for these findings.
UNASSIGNED: Case-control study of participants ≥ 50 years of age.
UNASSIGNED: A total of 202 eyes of 139 subjects (101 cases and 101 controls).
UNASSIGNED: All participants and controls underwent OCT and OCT angiography (OCTA), and parameters of subjects with AD were compared with those of cognitively normal controls.
UNASSIGNED: The foveal avascular zone (FAZ) area, vessel density (VD), and perfusion density (PD) in the superficial capillary plexus within the 3- and 6-mm circle and ring using Early Treatment Diabetic Retinopathy Study (ETDRS) grid overlay on OCTA; central subfield thickness (CST), retinal nerve fiber layer (RNFL) thickness, ganglion cell-inner plexiform layer (GCIPL) thickness, and choroidal vascularity index (CVI) on OCT.
UNASSIGNED: No significant sex differences in VD or PD were found in the AD or control cohorts; however, there were greater differences in VD and PD among AD female participants than AD male participants compared with their respective controls. The CST and FAZ area were not different between male and female AD participants. Among controls, men had a thicker CST (P < 0.001) and smaller FAZ area (P = 0.003) compared with women. The RNFL thickness, GCIPL thickness, and CVI were similar among male and female AD participants and controls.
UNASSIGNED: There may be a loss of the physiologic sex-related differences in retinal structure and microvasculature in those with AD compared with controls. Further studies are needed to elucidate the pathophysiological basis for these findings.
摘要：
UNASSIGNED：评估与年龄匹配的认知正常男性和女性对照相比，患有阿尔茨海默病（AD）的男性和女性在视网膜微脉管系统和结构以及脉络膜结构方面的差异。
UNASSIGNED：≥50岁参与者的病例对照研究。
未经评估：139名受试者共202只眼（101例和101例对照）。
UNASSIGNED：所有参与者和对照组均接受了OCT和OCT血管造影（OCTA），并将AD受试者的参数与认知正常对照组的参数进行比较。
UNASSIGNED：中央凹无血管区（FAZ）区域，血管密度（VD），使用OCTA上的早期治疗糖尿病视网膜病变研究（ETDRS）网格叠加在3毫米和6毫米圆和环内的浅表毛细血管丛中的灌注密度（PD）；中央子场厚度（CST），视网膜神经纤维层（RNFL）厚度，神经节细胞内丛状层（GCIPL）厚度，和OCT上的脉络膜血管指数（CVI）。
UNASSIGNED：在AD或对照组中未发现VD或PD的显著性别差异；然而，与各自的对照组相比,AD女性参与者的VD和PD差异大于AD男性参与者.男性和女性AD参与者的CST和FAZ区域没有差异。在控件中，与女性相比,男性的CST较厚(P<0.001),FAZ面积较小(P=0.003).RNFL厚度,GCIPL厚度,男性和女性AD参与者和对照组的CVI相似.
UNASSIGNED：与对照组相比，AD患者的视网膜结构和微脉管系统可能丧失生理性别相关差异。需要进一步的研究来阐明这些发现的病理生理学基础。
UNASSIGNED：≥50岁参与者的病例对照研究。
未经评估：139名受试者共202只眼（101例和101例对照）。
UNASSIGNED：所有参与者和对照组均接受了OCT和OCT血管造影（OCTA），并将AD受试者的参数与认知正常对照组的参数进行比较。
UNASSIGNED：中央凹无血管区（FAZ）区域，血管密度（VD），使用OCTA上的早期治疗糖尿病视网膜病变研究（ETDRS）网格叠加在3毫米和6毫米圆和环内的浅表毛细血管丛中的灌注密度（PD）；中央子场厚度（CST），视网膜神经纤维层（RNFL）厚度，神经节细胞内丛状层（GCIPL）厚度，和OCT上的脉络膜血管指数（CVI）。
UNASSIGNED：在AD或对照组中未发现VD或PD的显著性别差异；然而，与各自的对照组相比,AD女性参与者的VD和PD差异大于AD男性参与者.男性和女性AD参与者的CST和FAZ区域没有差异。在控件中，与女性相比,男性的CST较厚(P<0.001),FAZ面积较小(P=0.003).RNFL厚度,GCIPL厚度,男性和女性AD参与者和对照组的CVI相似.
UNASSIGNED：与对照组相比，AD患者的视网膜结构和微脉管系统可能丧失生理性别相关差异。需要进一步的研究来阐明这些发现的病理生理学基础。
