目的:本研究采用孟德尔随机化方法对循环蛋白进行系统评估,以确定新的血清生物标志物和高血压风险。
方法:使用孟德尔随机双样本评估了4,782种人循环蛋白与高血压风险之间的关联。FinnGen的研究表明,在85,438例病例和223,663例对照中,遗传易感性与高血压之间存在联系。
结果:逆方差加权和敏感性分析显示,循环中的9种蛋白质对高血压有致病作用。SMOC1和TIE1被确定为高血压发展可能性降低的致病因素,比值比为0.86(95%CI0.81-0.91;p=1.06e-06)和0.96(95%CI0.94-0.98;p=9.39e-05),分别。NDUFB4,ETHE1,POFUT2,TRIL,ADAM23,GXYLT1,OXT,TPST2和TMCC3显示可能与高血压有关。
结论:这项孟德尔随机双样本研究发现SMOC1和TIE1与高血压有因果关系,使它们成为有希望的治疗目标。
OBJECTIVE: This
study systematically assessed circulating proteins to identify new serum biomarkers and risk of hypertension using Mendelian randomisation.
METHODS: The associations between 4,782 human circulating proteins and the risk of hypertension were evaluated using two-sample Mendelian randomisation. The FinnGen
study demonstrated a link between genetic predisposition and hypertension in 85,438 cases and 223,663 controls.
RESULTS: Inverse variance weighted and sensitivity analysis revealed nine proteins in circulation that have a causative effect on hypertension. SMOC1 and TIE1 were determined to be causative factors in the decreased likelihood of developing hypertension, with odds ratios of 0.86 (95% CI 0.81-0.91; p=1.06e-06) and 0.96 (95% CI 0.94-0.98; p=9.39e-05), respectively. NDUFB4, ETHE1, POFUT2, TRIL, ADAM23, GXYLT1, OXT, TPST2, and TMCC3 showed a possible connection to hypertension.
CONCLUSIONS: This two-sample Mendelian randomisation
study found that SMOC1 and TIE1 are causally linked to hypertension, making them a promising target for therapy.