%0 Journal Article
%T Circulating Biomarkers and Risk of Hypertension: A Two-Sample Mendelian Randomisation Study.
%A Li J
%A Yao YX
%A Yao PS
%J Heart Lung Circ
%V 32
%N 12
%D 2023 Dec 1
%M 38042639
%F 2.838
%R 10.1016/j.hlc.2023.09.003
%X <B>OBJECTIVE: </B>This study systematically assessed circulating proteins to identify new serum biomarkers and risk of hypertension using Mendelian randomisation.<BR><B>METHODS: </B>The associations between 4,782 human circulating proteins and the risk of hypertension were evaluated using two-sample Mendelian randomisation. The FinnGen study demonstrated a link between genetic predisposition and hypertension in 85,438 cases and 223,663 controls.<BR><B>RESULTS: </B>Inverse variance weighted and sensitivity analysis revealed nine proteins in circulation that have a causative effect on hypertension. SMOC1 and TIE1 were determined to be causative factors in the decreased likelihood of developing hypertension, with odds ratios of 0.86 (95% CI 0.81-0.91; p=1.06e-06) and 0.96 (95% CI 0.94-0.98; p=9.39e-05), respectively. NDUFB4, ETHE1, POFUT2, TRIL, ADAM23, GXYLT1, OXT, TPST2, and TMCC3 showed a possible connection to hypertension.<BR><B>CONCLUSIONS: </B>This two-sample Mendelian randomisation study found that SMOC1 and TIE1 are causally linked to hypertension, making them a promising target for therapy.