目的:弥漫性大B细胞淋巴瘤(DLBCL)是非霍奇金淋巴瘤(NHL)最常见的类型。这项研究的目的是评估DLBCL的临床病理特征,在居住在巴基斯坦北部地区的受影响个体中,由于他们的偏远地区,他们以前没有被纳入重大淋巴瘤研究。
结果:患者的平均年龄为49.7岁。男性:女性比例为1.5:1。99例(71.74%)患者的原发部位为淋巴结,其中,36例(26.09%)患者有B期症状,19例(13.77%)患者有IV期疾病。39例(28.26%)患者有原发性淋巴结外受累,4例(2.90%)患者有B期症状,3例(2.17%)患者有IV期疾病。原发性淋巴结外DLBCL涉及的淋巴结外部位为胃肠道(GIT)19(48.72%),扁桃体6(15.38%),脊柱4(10.26%),软组织肿胀3(7.69%),腮腺2(5.13%),甲状腺2(5.13%)中枢神经系统(CNS)1(2.56),乳腺1(2.56%)和骨髓1(2.56%)。我们的研究显示,IV期和B症状的淋巴结DLBCL患者的百分比增加。很少有原发性淋巴结外DLBCL患者出现B症状和IV期疾病。GIT是原发性结外DLBCL中最常见的参与位点。
OBJECTIVE: Diffuse Large B Cell Lymphoma (DLBCL) is the most common type of Non-Hodgkin Lymphoma (NHL). The aim of this
study was to assess the clinico pathological characteristics of DLBCL specifically, among the affected individuals residing in Northern areas of Pakistan who had not been previously included in major lymphoma studies due to their remote location.
RESULTS: Mean age of the patients was 49.7 years. Male: female ratio was 1.5:1. Primary site was lymph node in 99 (71.74%) patients, out of which, 36 (26.09%) patients had B symptoms and 19 (13.77%) patients had stage IV disease. 39 (28.26%) patients had primary extra nodal involvement, 4 (2.90%) patients had B symptoms and 3 (2.17%) had stage IV disease. Extra
nodal sites involved in primary extra
nodal DLBCL were gastrointestinal tract (GIT) 19 (48.72%), tonsils 6 (15.38%), spine 4 (10.26%), soft tissue swelling 3 (7.69%), parotid gland 2 (5.13%), thyroid 2 (5.13%) central nervous system (CNS) 1 (2.56), breast 1 (2.56%) and bone marrow 1 (2.56%). Our
study revealed increased percentage of patients with
nodal DLBCL in stage IV and with B symptoms. Few patients with primary extra
nodal DLBCL had B symptoms and stage IV disease at presentation. GIT was the most common site of involvement in primary extra
nodal DLBCL.