Abstract：
Canine cutaneous mast cell tumours (cMCTs) of the pinna have been associated with an aggressive biological behaviour, although data remain scarce. The knowledge acquired over the past years on histologic gradings, and the value of lymph node (LN) staging, may help in better characterizing this anatomical presentation. The first aim was to describe the frequency, location, and histologic appearance of LN metastases in cMCT of the pinna. A second aim was to evaluate prognosis. Medical records of dogs with cMCT of the pinna, that underwent tumour and sentinel (SLN) or regional LN (RLN) excision, were reviewed. The influence of potential prognostic variables on time to progression (TTP) and tumour-specific survival (TSS) was investigated. Thirty-nine dogs were included: 19 (48.7%) had Kiupel high-grade (K-HG) and 20 (51.3%) had low-grade (K-LG) MCTs. Eighteen (46.1%) dogs underwent SLN mapping: the superficial cervical LN was at least one of SLN in 17 (94.4%) cases. Twenty-two (56.4%) dogs had LN metastases; the superficial cervical LN was always involved. On multivariable analysis, only K-HG was associated with increased risk of progression (p = .043) and tumour-related death (p = .021). Median TTP and TSS were 270 and 370 days in K-HG, respectively; these were not reached in dogs with K-LG tumours (p < .01). cMCTs of the pinna are often K-HG and are also associated with a higher frequency of LN metastasis; however, we confirmed the independent prognostic value of histologic grading. A multimodal treatment may lead to favourable long-term outcome. Moreover, the superficial cervical LN is most often the SLN.
摘要：
犬耳廓的皮肤肥大细胞肿瘤（cMCT）与侵袭性生物学行为有关，尽管数据仍然很少。过去几年获得的关于组织学分级的知识，淋巴结（LN）分期的价值，可能有助于更好地表征这种解剖学表现。第一个目的是描述频率，location,耳廓cMCT中LN转移的组织学表现。第二个目标是评估预后。带有耳廓cMCT的狗的医疗记录，接受了肿瘤和前哨(SLN)或区域LN(RLN)切除术，被审查了。研究了潜在预后变量对进展时间（TTP）和肿瘤特异性生存期（TSS）的影响。包括39只狗：19只（48.7％）具有Kiupel高等级（K-HG），20只（51.3％）具有低等级（K-LG）MCT。18只（46.1％）犬进行了SLN作图：在17例（94.4％）中，浅表宫颈LN至少是SLN之一。22只（56.4％）狗有LN转移；总是累及浅表宫颈LN。在多变量分析中，只有K-HG与进展风险增加(p=.043)和肿瘤相关死亡风险增加(p=.021)相关.K-HG的TTP和TSS中位数分别为270天和370天，分别；这些在患有K-LG肿瘤的狗中没有达到（p<0.01）。耳廓的cMCT通常是K-HG，并且也与LN转移的较高频率相关；然而，我们证实了组织学分级的独立预后价值.多模式治疗可能导致有利的长期结果。此外，颈浅层LN最常见的是SLN。
