New York City

纽约市
  • 文章类型: Journal Article
    2020年春季COVID-19激增,纽约市的呼吸机供应空前紧张,许多医院几乎耗尽了可用的呼吸机,随后认真考虑制定危机护理标准并实施纽约州呼吸机分配指南(NYVAG)。然而,几乎没有证据表明NYVAG如果实施会如何运作。
    为了评估NYVAG在患者激增期间的性能和潜在改善,总死亡率,和日益恶化的健康差距。
    这项队列研究包括2020年3月至7月在纽约市单一卫生系统中插管的患者。在危机期间,共进行了20000次呼吸机分流模拟(NYVAG后进行10000次,而在拟议的改进NYVAG后进行10000次),定义为使用前呼吸机供应95%的点。
    用于分诊呼吸机的NYVAG协议。
    观察到的存活率与需要NYVAG呼吸机配给的模拟情景的比较。
    总队列包括1671名患者;其中,674例插管患者(平均[SD]年龄,63.7[13.8]岁;465名男性[69.9%])被包括在危机期间,571(84.7%)的COVID-19检测呈阳性。在15.0天内,163.9名患者发生了模拟呼吸机配给,如果提供呼吸机,其中44.4%(95%CI,38.3%-50.0%)会存活,而新插管的患者中只有34.8%(95%CI,28.5%-40.0%)接受重新分配的呼吸机存活。虽然插管时的分诊分类显示出部分预后分化,所有呼吸机配给的94.8%发生在时间试验后。在这个子集内,43.1%的患者插管7天或更长时间,SOFA评分良好,但未改善。如果持续使用呼吸机,估计这些患者中有60.6%会存活。修订分诊子分类,提议改进的NYVAG,会改善这种令人震惊的呼吸机分配效率低下(如果提供呼吸机,则选择呼吸机配给的患者中有25.3%[95%CI,22.1%-28.4%]可以幸存)。NYVAG呼吸机配给并未加剧现有的健康差异。
    在这项队列研究中,在纽约市COVID-192020激增的顶点期间,插管患者经历了模拟呼吸机配给,NYVAG将呼吸机从生存机会较高的患者转移到生存机会较低的患者。未来的工作应该集中在分诊分类上,这改善了这种分类效率低下,经过时间试验后,呼吸机配给,当大多数呼吸机配给发生时。
    The spring 2020 surge of COVID-19 unprecedentedly strained ventilator supply in New York City, with many hospitals nearly exhausting available ventilators and subsequently seriously considering enacting crisis standards of care and implementing New York State Ventilator Allocation Guidelines (NYVAG). However, there is little evidence as to how NYVAG would perform if implemented.
    To evaluate the performance and potential improvement of NYVAG during a surge of patients with respect to the length of rationing, overall mortality, and worsening health disparities.
    This cohort study included intubated patients in a single health system in New York City from March through July 2020. A total of 20 000 simulations were conducted of ventilator triage (10 000 following NYVAG and 10 000 following a proposed improved NYVAG) during a crisis period, defined as the point at which the prepandemic ventilator supply was 95% utilized.
    The NYVAG protocol for triage ventilators.
    Comparison of observed survival rates with simulations of scenarios requiring NYVAG ventilator rationing.
    The total cohort included 1671 patients; of these, 674 intubated patients (mean [SD] age, 63.7 [13.8] years; 465 male [69.9%]) were included in the crisis period, with 571 (84.7%) testing positive for COVID-19. Simulated ventilator rationing occurred for 163.9 patients over 15.0 days, 44.4% (95% CI, 38.3%-50.0%) of whom would have survived if provided a ventilator while only 34.8% (95% CI, 28.5%-40.0%) of those newly intubated patients receiving a reallocated ventilator survived. While triage categorization at the time of intubation exhibited partial prognostic differentiation, 94.8% of all ventilator rationing occurred after a time trial. Within this subset, 43.1% were intubated for 7 or more days with a favorable SOFA score that had not improved. An estimated 60.6% of these patients would have survived if sustained on a ventilator. Revising triage subcategorization, proposed improved NYVAG, would have improved this alarming ventilator allocation inefficiency (25.3% [95% CI, 22.1%-28.4%] of those selected for ventilator rationing would have survived if provided a ventilator). NYVAG ventilator rationing did not exacerbate existing health disparities.
    In this cohort study of intubated patients experiencing simulated ventilator rationing during the apex of the New York City COVID-19 2020 surge, NYVAG diverted ventilators from patients with a higher chance of survival to those with a lower chance of survival. Future efforts should be focused on triage subcategorization, which improved this triage inefficiency, and ventilator rationing after a time trial, when most ventilator rationing occurred.
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  • 文章类型: Journal Article
    目的:研究美国妇产科医师学会和母胎医学学会(ACOG-SMFM)2014年预防不必要的初级剖腹产的建议的影响。
    方法:在2012-2016年纽约市以人口为基础的出生队列中,我们使用受控中断时间序列分析来估计未产者中年龄标准化剖宫产率的变化,term,单例顶点(NTSV)交付。
    结果:在40家医院的192,405例NTSV出生中,ACOG-SMFM建议后,年龄标准化的NTSV剖宫产率从25.8%下降至24.0%(风险比[RR]:0.93;95%CI0.89,0.97),在控制系列中没有变化。在非西班牙裔白人女性中观察到下降(RR:0.89;95%CI0.82,0.97),但非西班牙裔黑人女性中没有(RR:0.97;95%CI0.88,1.07),亚洲/太平洋岛民(RR:1.01;95%CI0.91,1.12),或西班牙裔女性(RR:0.94;95%CI0.86,1.02)。在教学医院观察到类似的模式,在非教学医院没有变化。
    结论:虽然低风险剖宫产率可以通过改变分娩管理来改变,需要更多的研究和干预措施来解决剖宫产差异问题.
    To examine the impact of the American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine (ACOG-SMFM) 2014 recommendations for preventing unnecessary primary Cesareans.
    In a population-based cohort of births in New York City from 2012 to 2016, we used controlled interrupted time series analyses to estimate changes in age-standardized Cesarean rates among nulliparous, term, singleton vertex (NTSV) deliveries.
    Among 192,405 NTSV births across 40 hospitals, the age-standardized NTSV Cesarean rate decreased after the ACOG-SMFM recommendations from 25.8% to 24.0% (Risk ratio [RR]: 0.93; 95% CI 0.89, 0.97), with no change in the control series. Decreases were observed among non-Hispanic White women (RR: 0.89; 95% CI 0.82, 0.97), but not among non-Hispanic Black women (RR: 0.97; 95% CI 0.88, 1.07), Asian/Pacific Islanders (RR: 1.01; 95% CI 0.91, 1.12), or Hispanic women (RR: 0.94; 95% CI 0.86, 1.02). Similar patterns were observed at teaching hospitals, with no change at nonteaching hospitals.
    While low-risk Cesarean rates may be modifiable through changes in labor management, additional research, and interventions to address Cesarean disparities, are needed.
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  • 文章类型: Journal Article
    目的:模拟基于序贯器官衰竭评估(SOFA)评分的呼吸机配置指南在COVID-19大流行期间的表现。
    方法:采用回顾性队列研究设计。研究地点包括3个纽约市医院在一个学术医疗中心。我们纳入了从2020年3月25日至2020年4月29日插管的成年患者(1002)的随机样本(205)。适用于纽约州2015年指南的协议标准,以确定哪些患者将停止或撤回机械通气。
    结果:根据分诊指南,117(57%)名患者会被确定为停用或扣留呼吸机。在这117名患者中,28(24%)存活住院。总的来说,65例(32%)患者存活出院。
    结论:分诊方案旨在通过将呼吸机重定向到最有可能存活的患者来最大化存活。超过50%的该样品将被鉴定为呼吸机排除的候选者。因此,在呼吸机重新分配中仍然需要临床判断,从而重新引入偏见和道德困扰。该数据表明基于SOFA评分的呼吸机配给的效用有限。它提出了一个问题,即是否有足够的道德理由对某些患者施加基于SOFA评分方法的终身决定,以便为少数其他患者提供潜在的利益。
    To model performance of the Sequential Organ Failure Assessment (SOFA) score-based ventilator allocation guidelines during the COVID-19 pandemic.
    A retrospective cohort study design was used. Study sites included 3 New York City hospitals in a single academic medical center. We included a random sample (205) of adult patients who were intubated (1002) from March 25, 2020, till April 29, 2020. Protocol criteria adapted from the New York State\'s 2015 guidelines were applied to determine which patients would have had mechanical ventilation withheld or withdrawn.
    117 (57%) patients would have been identified for ventilator withdrawal or withholding based on the triage guidelines. Of those 117 patients, 28 (24%) survived hospitalization. Overall, 65 (32%) patients survived to discharge.
    Triage protocols aim to maximize survival by redirecting ventilators to those most likely to survive. Over 50% of this sample would have been identified as candidates for ventilator exclusion. Clinical judgment would therefore still be needed in ventilator reallocation, thus re-introducing bias and moral distress. This data suggests limited utility for SOFA score-based ventilator rationing. It raises the question of whether there is sufficient ethical justification to impose a life-ending decision based on a SOFA scoring method on some patients in order to offer potential benefit to a modest number of others.
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  • 文章类型: Historical Article
    The issues addressed in this article are those related to the bioethical actions and decisions surrounding the excavation of the New York African Burial Ground (NYABG) in the 1990s, the significance of conducting research on historical African/African American remains, and the eminence of protecting newly discovered African American burial sites in the future for research purposes.
    Skeletal (n = 419, at the time of excavation) and soil (n = 92) remains of the 17th and 18th century New York African Burial Ground were used to discuss the necessity of research on historical African/African American remains.
    Studying the remains of enslaved Africans is critical to understanding the biological processes and existence of all people. Researching the NYABG site, the oldest and largest burial site of free and enslaved Africans, illuminates the necessity and significance of scientific research on other historical African/African American cemeteries throughout the nation. The results of future research will provide a more profound sense of identity for a group of people who were forcefully severed from their genetic and cultural origins. This research will increase the representation of African descended people in genomic, anthropological, and cultural research, and ultimately help researchers to learn more about the origins of all humans.
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  • 文章类型: Journal Article
    As research and attention on implicit bias and inclusiveness in medical school is expanding, institutions need mechanisms for recognizing, reporting, and addressing instances of implicit bias and lack of inclusiveness in medical school curricular structures. These instances can come as a result of a lack of both awareness and communication around these sensitive issues. To identify and address cases of implicit bias in the medical school curriculum, a student-led initiative at Columbia University Vagelos College of Physicians and Surgeons (VP&S) developed guidelines and a bias-reporting process for educators and students. The guidelines, co-created by students and faculty, help educators identify and address implicit bias in the curriculum. Furthermore, to allow for continued development of the curriculum and the guidelines themselves, the group adapted an existing learning environment reporting and review process to identify and address instances of implicit bias. In the first year since their implementation, these tools have already had an impact on the learning climate at VP&S. They have led to enhanced identification of implicit bias in the curriculum and changes in instructional materials. The courage and inspiration of the students and the initial investment and commitment from the administration and faculty were crucial to this rapid effect. The authors present an approach and resources from which other institutions can learn, with the goal of reducing implicit bias and improving inclusiveness throughout medical education. In the long run, the authors hope that these interventions will contribute to better preparing future providers to care for all patients equitably.
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  • 文章类型: Journal Article
    OBJECTIVE: During the COVID-19 pandemic, experience-based guidelines are needed in the pediatric population in order to deliver high quality care in a new way that keeps patients and healthcare workers safe and maximizes hospital resource utilization.
    BACKGROUND: The COVID-19 pandemic has created an unprecedented strain on national health care resources, particularly in New York City, the epicenter of the outbreak in the United States. Prudent allocation of surgical resources during the pandemic quickly became essential, and there is an unprecedented need to weigh the risks of operating versus delaying intervention in our pediatric patients.
    METHODS: Here we describe our experience in surgical decision-making in the pediatric surgical population at Morgan Stanley Children\'s Hospital of New York-Presbyterian (MSCHONY), which has served as a major urban catchment area for COVID-19 positive pediatric patients. We describe how we have adjusted our current treatment of multiple facets of pediatric surgery including oncology, trauma, minimally invasive procedures, and extracorporeal membrane oxygenation (ECMO).
    CONCLUSIONS: Our pediatric surgery department had to creatively and expeditiously adjust our protocols, guidelines, and workforce to not only serve our pediatric population but merge ourselves with our adult hospital system during the COVID pandemic.
    METHODS: Clinical research paper LEVEL OF EVIDENCE: Level V.
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  • 文章类型: Journal Article
    Practice facilitation is a promising practice transformation strategy, but further examination of its effectiveness in improving adoption of guidelines for multiple cardiovascular disease risk factors is needed. The objective of the study is to determine whether practice facilitation is effective in increasing the proportion of patients meeting the Million Hearts ABCS outcomes: (A) aspirin when indicated, (B) blood pressure control, (C) cholesterol management, and (S) smoking screening and cessation intervention.
    The study used a stepped-wedge cluster RCT design with 4 intervention waves. Data were extracted for 13 quarters between January 1, 2015 and March 31, 2018, which encompassed the control, intervention, and follow-up periods for all waves, and analyzed in 2019.
    A total of 257 small independent primary care practices in New York City were randomized into 1 of 4 waves.
    The intervention consisted of practice facilitators conducting at least 13 practice visits over 1 year, focused on capacity building and implementing system and workflow changes to meet cardiovascular disease care guidelines.
    The main outcomes were the Million Hearts\' ABCS measures. Two additional measures were created: (1) proportion of tobacco users who received a cessation intervention (smokers counseled) and (2) a composite measure that assessed the proportion of patients meeting treatment targets for A, B, and C (ABC composite).
    The S measure improved when comparing follow-up with the control period (incidence rate ratio=1.152, 95% CI=1.072, 1.238, p<0.001) and when comparing follow-up with intervention (incidence rate ratio=1.060, 95% CI=1.013, 1.109, p=0.007). Smokers counseled improved when comparing the intervention period with control (incidence rate ratio=1.121, 95% CI=1.037, 1.211, p=0.002).
    Increasing the impact of practice facilitation programs that target multiple risk factors may require a longer, more intense intervention and greater attention to external policy and practice context.
    This study is registered at www.clinicaltrials.gov NCT02646488.
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  • 文章类型: Journal Article
    Obesity is significantly associated with uncontrolled blood pressure and resistant hypertension (RH). There are limited studies on the prevalence and determinants of RH in patients with higher body mass index (BMI) values. Since the hypertension guidelines changed in 2017, the prevalence of RH has become unknown and now is subject to be estimated by further studies. We conducted a cross-sectional study in an urban Federally Qualified Health Center in New York City aiming to estimate the prevalence of RH in high-risk overweight and obese patients based on the new hypertension definition, BP threshold ≥130/80 mm Hg, and also to describe the associated comorbid conditions in these patients. We identified 761 eligible high-risk overweight and obese subjects with hypertension between October 2017 and October 2018. Apparent treatment-RH was found in 13.6% among the entire study population. This represented 15.4% of those treated with BP-lowering agents. True RH confirmed with out-of-office elevated BP was found in 6.7% of the study population and 7.4% among patients treated with BP-lowering agents. Prevalence was higher with higher BMI values. Those with true RH were more likely to be black, to have diabetes mellitus requiring insulin, chronic kidney disease stage 3 or above and diastolic heart failure. In conclusion, obesity is significantly associated with RH and other significant metabolic comorbid conditions.
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  • 文章类型: Evaluation Study
    目的:本研究的目的是确定在急诊科评估可疑肺栓塞(PE)的CT肺动脉造影指南不一致排序的发生率和可能的原因。
    方法:对急诊科的212例连续(2016年1月6日至2016年2月25日)的208例独特患者进行了回顾性研究,这些患者导致了CT肺动脉造影。对于每一次相遇,计算了修订后的日内瓦评分和两个版本的Wells标准.然后使用两级风险分层方法(PE不太可能与PE可能)对每次遭遇进行分类。最后,指南不一致排序的发生率和可能的解释通过深入图表审查进行评估.
    结果:指南不一致研究的频率范围从53(25%)到79(37%),取决于所使用的评分系统;其中46(22%)在所有三种评分系统下都存在指南不一致.其中,18(39%)至少有一个患者特异性因素与PE风险增加相关,但未包括在风险分层评分中(例如,旅行,血栓形成倾向)。
    结论:许多指南不一致的命令是针对那些存在基于证据的PE风险因素但未包括在风险分层评分中的患者。因此,指南不一致的排序可能表明,在存在这些因素的情况下,当前评分系统对风险的评估可能与临床怀疑不一致.
    OBJECTIVE: The aim of this study was to determine rates of and possible reasons for guideline-discordant ordering of CT pulmonary angiography for the evaluation of suspected pulmonary embolism (PE) in the emergency department.
    METHODS: A retrospective review was performed of 212 consecutive encounters (January 6, 2016, to February 25, 2016) with 208 unique patients in the emergency department that resulted in CT pulmonary angiography orders. For each encounter, the revised Geneva score and two versions of the Wells criteria were calculated. Each encounter was then classified using a two-tiered risk stratification method (PE unlikely versus PE likely). Finally, the rate of and possible explanations for guideline-discordant ordering were assessed via in-depth chart review.
    RESULTS: The frequency of guideline-discordant studies ranged from 53 (25%) to 79 (37%), depending on the scoring system used; 46 (22%) of which were guideline discordant under all three scoring systems. Of these, 18 (39%) had at least one patient-specific factor associated with increased risk for PE but not included in the risk stratification scores (eg, travel, thrombophilia).
    CONCLUSIONS: Many of the guideline-discordant orders were placed for patients who presented with evidence-based risk factors for PE that are not included in the risk stratification scores. Therefore, guideline-discordant ordering may indicate that in the presence of these factors, the assessment of risk made by current scoring systems may not align with clinical suspicion.
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  • 文章类型: Journal Article
    Practice guidelines have been published for bronchiolitis and community-acquired pneumonia (CAP), but little is known about pediatricians\' knowledge of and attitudes toward these guidelines since their publication.
    We surveyed pediatric providers at 6 children\'s hospitals in the New York City area. Two vignettes, an infant with bronchiolitis and a child with CAP, were provided, and respondents were asked about management. Associations between respondent characteristics and their reported practices were examined using χ2 and Fisher\'s exact tests. Associations between questions probing knowledge and attitude barriers relevant to guideline adherence and reported practices were examined using Cochran-Mantel-Haenszel relative risk estimates.
    Of 283 respondents, 58% were trainees; 57% of attending physician respondents had finished training within 10 years. Overall, 76% and 45% of respondents reported they had read the bronchiolitis and CAP guidelines, respectively. For the bronchiolitis vignette, 40% reported ordering a chest radiograph (CXR), and 38% prescribed bronchodilators (neither recommended). For the CAP vignette, 38% prescribed ceftriaxone (not recommended). Study site, level of training, and practice locations were associated with nonrecommended practices. Site-adjusted knowledge and attitude barriers were used to identify that those who agreed CXRs were useful in managing bronchiolitis were more likely to order CXRs, and those who felt bronchodilators shortened length of stay were more likely to prescribe them. Concerns about ampicillin resistance and lack of confidence using local susceptibility patterns to guide prescribing were associated with ordering ceftriaxone.
    Provider-level factors and knowledge gaps were associated with ordering nonrecommended treatments for bronchiolitis and CAP.
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