未经证实:多囊卵巢综合征(PCOS)始于青春期,并在以后几年有心血管和代谢成分。胱抑素C和高敏C反应蛋白(hs-CRP)水平以及中性粒细胞-淋巴细胞和血小板-淋巴细胞比率与代谢和炎症事件相关。这里,我们评估了正常和超重PCOS青少年的炎症和代谢参数.
UNASSIGNED:这项前瞻性病例对照研究纳入了90名PCOS青少年和100名年龄和BMI健康青少年,分为正常体重(NW)和超重(OW)。根据炎症和代谢参数(血清胱抑素C,hs-CRP,中性粒细胞-淋巴细胞比率(NLR),血小板-淋巴细胞比率(PLR),脂质,空腹血糖-胰岛素(FBG-FI),HOMA-IR水平,腰围[WC],和腰臀比[WHR])。比较参数之间的关系并评估预测能力。
未经批准:胱抑素C,hs-CRP,NLR,甘油三酯(TG),FBG-FI,HOMA-IR,WC,PCOS患者的WHR明显更高。NWPCOS组TG明显增高,胱抑素C,hs-CRP,以及NLR与OW控件。在OWPCOS中观察到最高的HOMA-IR值(p<0.05)。胱抑素C和hs-CRP敏感性和特异性差异有统计学意义(p<0.05)。胱抑素C和hs-CRP与其他代谢指标呈正相关。
未经批准:与BMI无关,与对照组相比,PCOS青少年的炎症和代谢参数明显更高,而OW青少年的炎症和代谢参数甚至更差。因此,应鼓励PCOS青少年保持健康的生活方式和体重,以避免代谢风险.Hs-CRP和胱抑素C可能是预测未来代谢风险的有希望的标志物。
UNASSIGNED: Polycystic ovary syndrome (PCOS) begins in adolescence and has cardiovascular and metabolic components in later years. Cystatin C and high-sensitivity C-reactive protein (hs-CRP) levels and neutrophil-lymphocyte and platelet-lymphocyte ratios are associated with metabolic and inflammatory events. Here, we evaluated inflammatory and metabolic parameters in normal and overweight adolescents with PCOS.
UNASSIGNED: This prospective
case-control study enrolled 90 adolescents with PCOS and 100 matched by age and BMI healthy adolescents classified as either normal weight (NW) and overweight (OW). Groups were compared based on inflammatory and metabolic parameters (serum cystatin C, hs-CRP, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lipids, fasting blood glucose-insulin (FBG-FI), HOMA-IR levels, waist circumference [WC], and waist-hip ratio [WHR]). The relationship between the parameters were compared and predictive abilities were evaluated.
UNASSIGNED: Cystatin C, hs-CRP, NLR, triglyceride (TG), FBG-FI, HOMA-IR, WC, and WHR were significantly higher in those with PCOS. The NW PCOS group had significantly higher TG, cystatin C, hs-CRP, and NLR versus OW controls. The highest HOMA-IR values were observed in OW PCOS (p < .05). Cystatin C and hs-CRP sensitivity and specificity were significant (p < 0.05). Cystatin C and hs-CRP were positively correlated with other metabolic parameters.
UNASSIGNED: Independent of BMI, inflammatory and metabolic parameters are significantly higher in adolescents with PCOS compared to controls and even worse in those who are also OW. Therefore, adolescents with PCOS should be encouraged to maintain healthy lifestyles and weights to avoid metabolic risks. Hs-CRP and cystatin C could be promising markers to predictive of future metabolic risks.