帕金森病(PD)是一种神经退行性疾病,其特征是黑质中多巴胺能神经元的丢失,导致多巴胺水平降低。导致电机类型的干扰。不同的脊椎动物模型,比如啮齿动物和鱼,被用来研究PD.近几十年来,Daniorerio(斑马鱼)由于与人类神经系统的同源性,已成为研究神经退行性疾病的潜在模型。在这种情况下,本系统综述旨在确定报道神经毒素作为斑马鱼胚胎和幼虫帕金森病的实验模型的出版物.最终,通过搜索三个数据库(PubMed,WebofScience,和谷歌学者)。使用1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)的17项研究,41-甲基-4-苯基吡啶(MPP),246-羟基多巴胺(6-OHDA),6百草枯/敌草,2鱼藤酮,选择使用其他类型的异常神经毒素诱导PD的6篇文章。神经行为功能,如运动活动,多巴胺能神经元标记,氧化应激生物标志物,并检查了斑马鱼胚胎-幼虫模型中的其他相关参数。总之,这篇综述提供了信息,以帮助研究人员确定哪种化学模型适合研究实验性帕金森病,根据神经毒素在斑马鱼胚胎和幼虫中的作用。
Parkinson\'s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra that results in a decrease in dopamine levels, resulting in motor-type disturbances. Different vertebrate models, such as rodents and fish, have been used to study PD. In recent decades, Danio rerio (zebrafish) has emerged as a potential model for the investigation of neurodegenerative diseases due to its homology to the nervous system of humans. In this context, this systematic
review aimed to identify publications that reported the utilization of neurotoxins as an experimental model of parkinsonism in zebrafish embryos and larvae. Ultimately, 56 articles were identified by searching three databases (PubMed, Web of Science, and Google Scholar). Seventeen studies using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 4 1-methyl-4-phenylpyridinium (MPP+), 24 6-hydroxydopamine (6-OHDA), 6 paraquat/diquat, 2 rotenone, and 6 articles using other types of unusual neurotoxins to induce PD were selected. Neurobehavioral function, such as motor activity, dopaminergic neuron markers, oxidative stress biomarkers, and other relevant parameters in the zebrafish embryo-larval model were examined. In summary, this
review provides information to help researchers determine which chemical model is suitable to study experimental parkinsonism, according to the effects induced by neurotoxins in zebrafish embryos and larvae.