背景:先前的研究表明,妊娠期母体必需微量元素失衡与自然流产(SA)的发生之间存在相关性。尽管如此,这些因素对双方以及孕前时期的影响仍未得到探索。
目的:本研究旨在基于夫妻关系评估孕前必需微量元素与自然流产(SA)之间的关系。
方法:本研究从33,687对孕前队列中选择了390对自然流产(SA)夫妇和390对配对的活产夫妇。分析了怀孕前收集的尿液样本中的十种必需微量元素(Se,Cr,Mo,Cu,Zn,Fe,Mn,V,Co,和Ni)使用电感耦合等离子体质谱法(ICP-MS)。
结果:多变量条件逻辑回归分析发现,夫妇中锌(OR=0.73)和镍(OR=0.69)浓度升高与SA风险降低相关。而Cr(OR=1.30)和Mn(OR=1.39)水平升高与风险增加有关。受限制的三次样条模型表明,铜和钴浓度与SA之间存在U形关联。贝叶斯核机回归进一步支持了十个元素的混合与SA之间的U形关系,与第10百分位数相比,在第50和第55百分位数显示出显著的保护。此外,Cr的影响,Zn,Mn,当其他九种元素的浓度保持不变时,SA上的Ni会发生变化,50岁,和第75百分位数。分层分析表明,当父系Cu和Fe处于下四分位数时,母系Cu(OR=0.43)和Fe(OR=0.63)降低了SA的风险。相反,母体Cu(OR=2.03)和Fe(OR=1.77)在父系浓度较高的四分位数时增加SA的风险。Cr也观察到类似的模式,Mn,Co,和Zn。
结论:夫妇尿锌和镍浓度升高与SA风险降低相关,而较高的Cr和Mn水平与风险增加有关。Cu,Co,十种必需微量元素的混合物与SA呈U型关系。某些必需微量元素(Cu,Fe,Cr,Mn,Co,和Zn)在一个伴侣中的SA受到其在另一个伴侣中的浓度的影响。
BACKGROUND: Previous studies have indicated a correlation between maternal imbalances in essential trace elements during pregnancy and the occurrence of spontaneous abortion (SA). Nonetheless, the impact of these elements from both partners and during the preconception period remains unexplored.
OBJECTIVE: This
study sought to evaluate the relationship between preconception essential trace elements and spontaneous abortion (SA) based on husband-wife dyads.
METHODS: This
study selected 390 couples with spontaneous abortion (SA) and 390 matched couples with live births from a preconception cohort of 33,687 couples. Urine samples collected prior to pregnancy were analyzed for ten essential trace elements (Se, Cr, Mo, Cu, Zn, Fe, Mn, V, Co, and Ni) using inductively coupled plasma mass spectrometry (ICP-MS).
RESULTS: Multivariate conditional logistic regression analysis identified that elevated concentrations of Zn (OR = 0.73) and Ni (OR = 0.69) in couples were associated with a reduced risk of SA, whereas elevated levels of Cr (OR = 1.30) and Mn (OR = 1.39) were linked to an increased risk. Restricted cubic spline models suggested a U-shaped association between couples\' Cu and Co concentrations and SA. Bayesian Kernel Machine Regression further supported a U-shaped relationship between the mixture of ten elements and SA, showing significant protection at the 50th and 55th percentiles compared to the 10th percentile. Additionally, the effects of Cr, Zn, Mn, and Ni on SA varied when the concentrations of the other nine elements were held constant at their 25th, 50th, and 75th percentiles. Stratified analysis revealed that maternal Cu (OR = 0.43) and Fe (OR = 0.63) reduced the risk of SA when paternal Cu and Fe were in the lower quartile. Conversely, maternal Cu (OR = 2.03) and Fe (OR = 1.77) increased the risk of SA when paternal concentrations were in the higher quartile. Similar patterns were observed for Cr, Mn, Co, and Zn.
CONCLUSIONS: Elevated urinary concentrations of Zn and Ni in couples were associated with a reduced risk of SA, while higher levels of Cr and Mn were linked to an increased risk. Cu, Co, and a mixture of ten essential trace elements exhibited a U-shaped relationship with SA. The impact of certain essential trace elements (Cu, Fe, Cr, Mn, Co, and Zn) on SA in one partner was influenced by their concentrations in the other partner.