PDF(Pubmed)
Abstract：
Growing research has proposed that rheumatoid arthritis (RA) and chronic periodontitis (CP) share similar pathophysiological mechanisms involving inflammation and tissue destruction. However, the potential correlation of CP as a contributing factor for the occurrence of RA warrants validation in the Korean population, where both diseases are prevalent, especially considering the increasingly aging demographic in Korea. This study examined 5139 RA cases and 509,727 matched controls from a Korean national cohort dataset (2002-2019) by carefully employing propensity score matching to ensure comparability between groups. Baseline characteristics were compared using standardized differences, and logistic regression was employed to estimate the impact of CP history on RA likelihood while controlling for covariates. We fully examined medical records documenting CP occurrences within the two-year period leading up to the index date, conducting comprehensive subgroup analyses. While a 1-year history of CP did not show a significant association with likelihood of RA, a 2-year history of CP increased RA likelihood by 12%, particularly among older adults, females, rural residents, and those with certain comorbidities such as hypercholesterolemia. Interestingly, this association persisted even among individuals with non-smoking habits, normal weight, and infrequent alcohol consumption. These findings suggest that chronic CP exposure for at least 2 years may independently elevate RA risk in Korean adults. The association in certain subgroups appears to suggest a predisposition toward genetic susceptibilities over lifestyle and environmental factors. Predicting RA in CP patients may be challenging, emphasizing the importance of regular RA screening, especially in high-risk subgroups.
摘要：
越来越多的研究表明，类风湿性关节炎（RA）和慢性牙周炎（CP）具有相似的病理生理机制，涉及炎症和组织破坏。然而,在韩国人群中，CP作为RA发生的一个促成因素的潜在相关性值得验证，这两种疾病都很普遍，特别是考虑到韩国人口日益老龄化。这项研究通过仔细采用倾向评分匹配来确保组间的可比性，从韩国国家队列数据集（2002-2019）中检查了5139例RA病例和509,727例匹配的对照。使用标准化差异比较基线特征，在控制协变量的同时,采用logistic回归估计CP病史对RA可能性的影响.我们全面检查了记录在索引日期之前的两年内发生CP的医疗记录，进行全面的亚组分析。虽然1年的CP病史与RA的可能性没有显着关联，2年的CP病史使RA的可能性增加了12%，尤其是在老年人中，女性,农村居民,和那些有某些合并症，如高胆固醇血症。有趣的是,这种联系甚至在不吸烟习惯的个体中也持续存在，正常体重,很少饮酒。这些发现表明，至少2年的慢性CP暴露可能会独立地提高韩国成年人的RA风险。某些亚组中的关联似乎表明了对生活方式和环境因素的遗传敏感性的倾向。预测CP患者的RA可能具有挑战性，强调定期RA筛查的重要性，特别是在高危亚组。
