未经证实:霍奇金淋巴瘤(HL)是一种罕见的血液系统恶性肿瘤,主要发生在年轻人中,而较少发生在老年人中。HL具有来源于B淋巴细胞的特征性细胞(已知的Reed-Sternberg(HRS)细胞)。原发性肝霍奇金病非常罕见,占病例的不到0.4%。由于其罕见的发生,PHL的发病机制尚不清楚,临床表现,实验室发现,和成像特征通常是非特异性的,很难诊断。
未经授权:69岁沙特女性,已知的高血压病例出现在我们医院,有发热史,黄疸,食欲不振约2周,体重明显下降。
未经评估:实验室检查结果显示胆汁淤积型,总胆红素107.2mg/dl,碱性磷酸酶2076IU/l,AST153IU/l和ALT73IU/l。超声成像显示肝脏大小正常,弥漫性回声增加,MRCP显示胆囊内有多个结石,没有梗阻或CBD扩张的证据,而泛计算机断层扫描(CT)显示轻度增大和脂肪肝。CT引导下细针穿刺细胞学(FNAC)和肝脏活检与原发性肝霍奇金淋巴瘤一致。
UNASSIGNED:患者接受了5个周期的ABVD。
UNASSIGNED:完成5个周期后,患者对治疗表现出良好的反应,肝功能正常化,肝脏CT大小消退。
未经证实:PHL是一种罕见的疾病。临床表现是可变的,放射学特征不是特异性的。组织学是明确诊断的必要条件。PHL的最佳治疗和结果仍不清楚。ABVD是最经常使用的化疗方案。包括手术和放疗在内的多种方法是另一种选择。
UNASSIGNED: Hodgkin lymphoma (HL) is an uncommon hematological malignancy that primarily occurs in young adults and less frequently in elderly individuals. HL has characteristics cells derived from B lymphocytes (known Reed-Sternberg (HRS) cells). Primary hepatic Hodgkin disease is very rare presentation accounting for less than 0.4% of the cases. Due to its rare occurrence, the pathogenesis of PHL is still unclear, Clinical manifestations, laboratory findings, and imaging features are usually nonspecific, making it difficult to diagnose.
UNASSIGNED: 69 years old Saudi Female, known
case of Hypertension presented to our hospital with history of fever, jaundice, and poor appetite for about 2 weeks with significant weight loss.
UNASSIGNED: Laboratory findings showed cholestatic pattern with total bilirubin 107.2 mg/dl, alkaline phosphatase 2076 IU/l, AST 153 IU/l and ALT 73 IU/l. Imaging with US revealed normal liver size with diffuse increase echogenicity, MRCP showed multiple stones within the gallbladder without evidence of obstruction or CBD dilatation and pan-computed tomography (CT) revealed mildly enlarged and fatty liver. CT-guided fine needle aspiration cytology (FNAC) and biopsy from the liver were consistent with primary hepatic Hodgkins lymphoma.
UNASSIGNED: The patient received 5 cycles of ABVD.
UNASSIGNED: After the completion of the 5 cycles patient showed good response to the treatment with normalization of her liver function and regression in the size of liver on CT.
UNASSIGNED: PHL is a rare disease. The clinical presentation is variable and radiological features are not specific. Histology is mandatory for definitive diagnosis. The optimal therapy and outcomes for PHL is still unclear. ABVD is the most frequently used chemotherapy regimen. Multidisplinary approach including surgery and radiotherapy is another option.