未经证实:食用加工食品与鼻咽癌(NPC)有关,但结果不一致。因此,我们进行了系统评价和荟萃分析,以计算有关加工食品与纳入研究的NPC风险之间关联的结果.
UNASSIGNED:本研究包括探索加工食品消费与NPC风险之间关系的研究。所有纳入的研究均为病例对照或队列设计。PubMed,WebofScience,EMBASE,搜索了Medline和GoogleScholar数据库,以查找2021年7月之前发表的文章。我们记录了以下数据:作者,出版年份,样本量,研究类型,研究地点,多年的诊断,食物项目和比较,考虑的协变量是多变量调整后的比值比(ORs)或相对风险(RRs),相应的95%置信区间(CI)为最高vs.加工食品摄入量的最低类别。使用STATA12.0软件计算关联的多变量OR或RR和95%CI。使用Cochrane偏差风险工具进行质量评估。
UNASSIGNED:对29项病例对照研究(包括14,378例鼻咽癌患者和17,928例对照)进行了荟萃分析。荟萃分析显示,与随机效应模型中最低类别相比,最高类别的加工食品摄入量与NPC风险增加65%相关(OR=1.67;95%CI:1.56-1.79;Q检验的P值<0.001;I2=86.9%)。亚组研究显示,在亚洲人和白种人中,加工食品的消费与NPC风险之间存在显着正相关(亚洲人:OR=1.68,95%CI:1.56-1.81;高加索人:OR=1.36,95%CI:1.09-1.71)。
未经评估:加工食品与NPC风险的关联可能是显著的。需要进一步的前瞻性研究和实验研究来探索这种关系。
UNASSIGNED: Consumption of processed foods has been associated with nasopharyngeal carcinoma (NPC), but with inconsistent results. Therefore, we conducted a systematic
review and meta-analysis to compute results regarding the association between processed foods and risk of NPC in included studies.
UNASSIGNED: Studies exploring the association between consumption of processed food and risk of NPC were included in the present study. All included studies were case-control or cohort designed. PubMed, Web of Science, EMBASE, Medline and Google Scholar databases were searched for articles published before July 2021. We recorded the following data: author, publication year, sample size, study type, study location, years of diagnosis, food item and comparison, and the covariates considered were multivariate adjusted odds ratios (ORs) or relative risks (RRs) with corresponding 95% confidence intervals (CIs) for the highest vs. lowest categories of processed food intake. STATA 12.0 software was used to compute the multivariate ORs or RRs and 95% CIs of the association. Quality appraisal was made using the Cochrane Risk of Bias Tool.
UNASSIGNED: A meta-analysis was made for 29 case-control studies (including 14,378 NPC patients and 17,928 controls). The meta-analysis showed that the highest categories of processed food intake were associated with a 65% increase in NPC risk compared with the lowest categories in a random effects model (OR =1.67; 95% CI: 1.56-1.79; P value for Q test <0.001; I2=86.9%). Subgroup study showed significant positive associations regarding consumption of processed food and risk of NPC in both Asians and Caucasians (Asian: OR =1.68, 95% CI: 1.56-1.81; Caucasian: OR =1.36, 95% CI: 1.09-1.71).
UNASSIGNED: The association of processed foods with NPC risk might be significant. Further prospective studies and experimental research are needed to explore this relationship.