作为一种类似于泛素的蛋白质,神经前体细胞表达发育下调8(NEDD8)参与neddylation,它以类似于泛素化的方式修饰底物,并改变靶蛋白的活性。Neddylation可能会影响多个信号通路的活性,在肿瘤形成中起调节作用,进展和转移,并影响癌症治疗的预后。本综述总结了NEDD8在MDM2-p53,NF-κB,PI3K/AKT/mTOR,缺氧诱导因子,Hippo和受体酪氨酸激酶信号通路,以及肺癌的发展和进展。
As a protein that resembles ubiquitin, neural precursor cell expressed developmentally downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner similar to ubiquitination and alters the activity of target proteins. Neddylation may affect the activity of multiple signaling pathways, have a regulatory role in tumor formation, progression and metastasis, and influence the prognosis of cancer treatment. The present
review summarizes the regulatory roles of NEDD8 in the MDM2‑p53, NF‑κB, PI3K/AKT/mTOR, hypoxia‑inducible factor, Hippo and receptor tyrosine kinase signaling pathways, as well as in the development and progression of lung cancer.