■宫颈癌构成了一个相当大的世界性健康问题,其中人乳头瘤病毒(HPV)感染作为危险因素起着至关重要的作用。光动力疗法(PDT)是HPV相关宫颈病变的微创治疗方法,它使用光敏剂和光来选择性地破坏异常细胞。
■我们的目标是全面概述PDT中使用的不同类型的分子,以减少与宫颈癌相关的发生率和死亡率。
■范围审查和文献计量分析。
■本文探讨了研究PDT治疗低度鳞状上皮内病变和高度鳞状上皮内病变疗效的临床试验,以及在宫颈癌中利用各种分子进行PDT的临床前方法。此外,这篇文章揭示了PDT增强的潜在分子,通过计算机建模模拟检查它们的属性,分子对接,并评估它们的优缺点。
■我们的研究结果表明,PDT有望作为治疗与HPV和宫颈癌相关的宫颈病变的治疗方法。此外,我们观察到使用不同类型的染料增强了PDT的抗癌作用。
■在PDT中使用的各种分子中,功能化富勒烯对宫颈癌细胞中过度表达的受体表现出明显的倾向,使其成为在PDT中强化使用的潜在候选者。然而,需要进一步的研究来评估其长期有效性和安全性.
用光治疗宫颈癌:你需要知道的是,宫颈癌是一个重要的全球健康问题,通常与人乳头瘤病毒(HPV)有关。有一种侵入性较小的治疗方法,称为光动力疗法(PDT),它使用光和特殊物质来靶向和破坏与HPV相关的异常细胞。在这次审查中,我们旨在全面了解PDT中使用的不同物质,以减少宫颈癌的发生和严重程度。我们已经检查了专注于治疗特定类型的宫颈病变的临床试验,并探索了使用各种物质的临床前方法。我们还深入研究了计算机模拟和分子对接,以了解这些物质的优缺点。我们的发现表明,PDT具有治疗HPV相关宫颈病变和癌症的潜力。该疗法中使用的不同染料类别增强了其对抗癌症的有效性。值得注意的是,一种叫做功能化富勒烯的物质因其倾向于靶向宫颈癌细胞中过度表达的受体而脱颖而出。看起来很有希望,但是需要更多的研究来确保其长期有效性和安全性。
UNASSIGNED: Cervical cancer poses a considerable worldwide health issue, where infection with the human papillomavirus (HPV) plays a vital role as a risk factor. Photodynamic therapy (PDT) is a minimally invasive treatment for HPV-related cervical lesions, which uses photosensitizers and light to selectively destroy abnormal cells.
UNASSIGNED: Our objective is to present a comprehensive overview of the different types of molecules employed in PDT to reduce the occurrence and fatality rates associated with cervical cancer.
UNASSIGNED: Scoping
review and bibliometric analysis.
UNASSIGNED: The article explores clinical trials investigating the efficacy of PDT in treating low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion, as well as preclinical approaches utilizing various molecules for PDT in cervical cancer. Furthermore, the article sheds light on potential molecules for PDT enhancement, examining their properties through computer modeling simulations, molecular docking, and assessing their advantages and disadvantages.
UNASSIGNED: Our findings demonstrate that PDT holds promise as a therapeutic approach for treating cervical lesions associated with HPV and cervical cancer. Additionally, we observe that the utilization of diverse dye classes enhances the anticancer effects of PDT.
UNASSIGNED: Among the various molecules employed in PDT, functionalized fullerene exhibits a notable inclination toward overexpressed receptors in cervical cancer cells, making it a potential candidate for intensified use in PDT. However, further research is needed to evaluate its long-term effectiveness and safety.
Using light to treat cervical cancer: what you need to know Cervical cancer is a significant global health concern, often linked to the human papillomavirus (HPV). There is a less invasive treatment called photodynamic therapy (PDT), which employs light and special substances to target and destroy abnormal cells related to HPV. In this
review, we aim to give you a comprehensive look at the different substances used in PDT to reduce the occurrence and severity of cervical cancer. We have examined clinical trials focusing on treating specific types of cervical lesions and explored preclinical approaches using various substances. We have also delved into computer simulations and molecular docking to understand the strengths and weaknesses of these substances. Our findings show that PDT has potential as a treatment for HPV-related cervical lesions and cancer. Different dye classes used in this therapy enhance its effectiveness against cancer. Notably, a substance called functionalized fullerene stands out for its tendency to target receptors overexpressed in cervical cancer cells. It looks promising, but more research is necessary to ensure its long-term effectiveness and safety.