细胞外信号调节激酶1/2(ERK1/2)是一种丝氨酸/苏氨酸激酶,参与Ras-Raf-丝裂原活化蛋白激酶(MEK)-ERK的信号转导级联反应。它参与细胞生长,通过调节基因的转录和表达来实现增殖甚至侵袭。肺癌等多种疾病的发生,肝癌,卵巢癌,宫颈癌,子宫内膜异位症,先兆子痫,以及转移和疾病进展,与ERK1/2信号通路对细胞侵袭的调控密切相关。因此,探讨ERK1/2信号对细胞侵袭的调控及其在疾病发病机制中的作用可能有助于制定更有效的治疗方案。本文就ERK1/2信号对细胞侵袭的调控及其在疾病中的作用,以期为ERK1/2相关疾病的临床治疗提供新的见解。
Extracellular signal-regulated kinase 1/2 (ERK1/2) is a serine/threoninekinase involved in the signal transduction cascade of Ras-Raf-mitogen-activated protein kinase (MEK)-ERK.It participates in the cell growth,proliferation and even invasion by regulating gene transcription and expression.The occurrence of a variety of diseases such as lung cancer,liver cancer,ovarian cancer,cervical cancer,endometriosis,and preeclampsia,as well the metastasis and disease progression,is closely associated with the regulation of cell invasion by ERK1/2 signaling pathway.Therefore,exploring the regulation of ERK1/2 signaling on cell invasion and its role in pathogenesis of diseases may help to develop more effective treatment schemes.This article introduces recent progress in the regulation of ERK1/2 signaling on cell invasion and the role of such regulation in diseases,with a view to give new insights into the clinical treatment of ERK 1/2-related diseases.