UNASSIGNED: The rapid advancement of artificial intelligence (AI) has ushered in a new era in natural language processing (NLP), with large language models (LLMs) like ChatGPT leading the way. This paper explores the profound impact of AI, particularly LLMs, in the field of medical image processing. The objective is to provide insights into the transformative potential of AI in improving healthcare by addressing historical challenges associated with manual image interpretation.
UNASSIGNED: A comprehensive literature search was conducted on the Web of Science and PubMed databases from 2013 to 2023, focusing on the transformations of LLMs in Medical Imaging Processing. Recent publications on the arXiv database were also reviewed. Our search criteria included all types of articles, including abstracts, review articles, letters, and editorials. The language of publications was restricted to English to facilitate further content analysis.
UNASSIGNED: The review reveals that AI, driven by LLMs, has revolutionized medical image processing by streamlining the interpretation process, traditionally characterized by time-intensive manual efforts. AI\'s impact on medical care quality and patient well-being is substantial. With their robust interactivity and multimodal learning capabilities, LLMs offer immense potential for enhancing various aspects of medical image processing. Additionally, the Transformer architecture, foundational to LLMs, is gaining prominence in this domain.
UNASSIGNED: In conclusion, this review underscores the pivotal role of AI, especially LLMs, in advancing medical image processing. These technologies have the capacity to enhance transfer learning efficiency, integrate multimodal data, facilitate clinical interactivity, and optimize cost-efficiency in healthcare. The potential applications of LLMs in clinical settings are promising, with far-reaching implications for future research, clinical practice, and healthcare policy. The transformative impact of AI in medical image processing is undeniable, and its continued development and implementation are poised to reshape the healthcare landscape for the better.

Medical image analysis forms the basis of image-guided surgery (IGS) and many of its fundamental tasks. Driven by the growing number of medical imaging modalities, the research community of medical imaging has developed methods and achieved functionality breakthroughs. However, with the overwhelming pool of information in the literature, it has become increasingly challenging for researchers to extract context-relevant information for specific applications, especially when many widely used methods exist in a variety of versions optimized for their respective application domains. By being further equipped with sophisticated three-dimensional (3D) medical image visualization and digital reality technology, medical experts could enhance their performance capabilities in IGS by multiple folds. The goal of this narrative review is to organize the key components of IGS in the aspects of medical image processing and visualization with a new perspective and insights. The literature search was conducted using mainstream academic search engines with a combination of keywords relevant to the field up until mid-2022. This survey systemically summarizes the basic, mainstream, and state-of-the-art medical image processing methods as well as how visualization technology like augmented/mixed/virtual reality (AR/MR/VR) are enhancing performance in IGS. Further, we hope that this survey will shed some light on the future of IGS in the face of challenges and opportunities for the research directions of medical image processing and visualization.

Chest radiographs are widely used in the medical domain and at present, chest X-radiation particularly plays an important role in the diagnosis of medical conditions such as pneumonia and COVID-19 disease. The recent developments of deep learning techniques led to a promising performance in medical image classification and prediction tasks. With the availability of chest X-ray datasets and emerging trends in data engineering techniques, there is a growth in recent related publications. Recently, there have been only a few survey papers that addressed chest X-ray classification using deep learning techniques. However, they lack the analysis of the trends of recent studies. This systematic review paper explores and provides a comprehensive analysis of the related studies that have used deep learning techniques to analyze chest X-ray images. We present the state-of-the-art deep learning based pneumonia and COVID-19 detection solutions, trends in recent studies, publicly available datasets, guidance to follow a deep learning process, challenges and potential future research directions in this domain. The discoveries and the conclusions of the reviewed work have been organized in a way that researchers and developers working in the same domain can use this work to support them in taking decisions on their research.

Skin cancer is one of the most prevalent cancers worldwide. In the advent of medical digitization and telepathology, hyper/multispectral imaging (HMSI) allows for noninvasive, nonionizing tissue evaluation at a macroscopic level.
We aim to summarize proposed frameworks and recent trends in HMSI-based classification and segmentation of gross-level skin tissue.
A systematic review was performed, targeting HMSI-based systems for the classification and segmentation of skin lesions during gross pathology, including melanoma, pigmented lesions, and bruises. The review adhered to the 2020 Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. For eligible reports published from 2010 to 2020, trends in HMSI acquisition, preprocessing, and analysis were identified.
HMSI-based frameworks for skin tissue classification and segmentation vary greatly. Most reports implemented simple image processing or machine learning, due to small training datasets. Methodologies were evaluated on heavily curated datasets, with the majority targeting melanoma detection. The choice of preprocessing scheme influenced the performance of the system. Some form of dimension reduction is commonly applied to avoid redundancies that are inherent in HMSI systems.
To use HMSI for tumor margin detection in practice, the focus of system evaluation should shift toward the explainability and robustness of the decision-making process.

Deep learning has remarkably impacted several different scientific disciplines over the last few years. For example, in image processing and analysis, deep learning algorithms were able to outperform other cutting-edge methods. Additionally, deep learning has delivered state-of-the-art results in tasks like autonomous driving, outclassing previous attempts. There are even instances where deep learning outperformed humans, for example with object recognition and gaming. Deep learning is also showing vast potential in the medical domain. With the collection of large quantities of patient records and data, and a trend towards personalized treatments, there is a great need for automated and reliable processing and analysis of health information. Patient data is not only collected in clinical centers, like hospitals and private practices, but also by mobile healthcare apps or online websites. The abundance of collected patient data and the recent growth in the deep learning field has resulted in a large increase in research efforts. In Q2/2020, the search engine PubMed returned already over 11,000 results for the search term \'deep learning\', and around 90% of these publications are from the last three years. However, even though PubMed represents the largest search engine in the medical field, it does not cover all medical-related publications. Hence, a complete overview of the field of \'medical deep learning\' is almost impossible to obtain and acquiring a full overview of medical sub-fields is becoming increasingly more difficult. Nevertheless, several review and survey articles about medical deep learning have been published within the last few years. They focus, in general, on specific medical scenarios, like the analysis of medical images containing specific pathologies. With these surveys as a foundation, the aim of this article is to provide the first high-level, systematic meta-review of medical deep learning surveys.

Being a second most cause of mortality worldwide, cancer has been identified as a perilous disease for human beings, where advance stage diagnosis may not help much in safeguarding patients from mortality. Thus, efforts to provide a sustainable architecture with proven cancer prevention estimate and provision for early diagnosis of cancer is the need of hours. Advent of machine learning methods enriched cancer diagnosis area with its overwhelmed efficiency & low error-rate then humans. A significant revolution has been witnessed in the development of machine learning & deep learning assisted system for segmentation & classification of various cancers during past decade. This research paper includes a review of various types of cancer detection via different data modalities using machine learning & deep learning-based methods along with different feature extraction techniques and benchmark datasets utilized in the recent six years studies. The focus of this study is to review, analyse, classify, and address the recent development in cancer detection and diagnosis of six types of cancers i.e., breast, lung, liver, skin, brain and pancreatic cancer, using machine learning & deep learning techniques. Various state-of-the-art technique are clustered into same group and results are examined through key performance indicators like accuracy, area under the curve, precision, sensitivity, dice score on benchmark datasets and concluded with future research work challenges.

The larynx, or the voice-box, is a common site of occurrence of Head and Neck cancers. Yet, automated segmentation of the larynx has been receiving very little attention. Segmentation of organs is an essential step in cancer treatment-planning. Computed Tomography scans are routinely used to assess the extent of tumor spread in the Head and Neck as they are fast to acquire and tolerant to some movement. This paper reviews various automated detection and segmentation methods used for the larynx on Computed Tomography images. Image registration and deep learning approaches to segmenting the laryngeal anatomy are compared, highlighting their strengths and shortcomings. A list of available annotated laryngeal computed tomography datasets is compiled for encouraging further research. Commercial software currently available for larynx contouring are briefed in our work. We conclude that the lack of standardisation on larynx boundaries and the complexity of the relatively small structure makes automated segmentation of the larynx on computed tomography images a challenge. Reliable computer aided intervention in the contouring and segmentation process will help clinicians easily verify their findings and look for oversight in diagnosis. This review is useful for research that works with artificial intelligence in Head and Neck cancer, specifically that deals with the segmentation of laryngeal anatomy.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s13534-022-00221-3.

COVID-19 is a fast-spreading pandemic, and early detection is crucial for stopping the spread of infection. Lung images are used in the detection of coronavirus infection. Chest X-ray (CXR) and computed tomography (CT) images are available for the detection of COVID-19. Deep learning methods have been proven efficient and better performing in many computer vision and medical imaging applications. In the rise of the COVID pandemic, researchers are using deep learning methods to detect coronavirus infection in lung images. In this paper, the currently available deep learning methods that are used to detect coronavirus infection in lung images are surveyed. The available methodologies, public datasets, datasets that are used by each method and evaluation metrics are summarized in this paper to help future researchers. The evaluation metrics that are used by the methods are comprehensively compared.

OBJECTIVE: Cholangiocarcinoma (CCA) is one of the most aggressive human malignant tumors and is becoming one of the main factors of death and disability globally. Specifically, 60% to 70% of CCA patients were diagnosed with local invasion or distant metastasis and lost the chance of radical operation. The overall median survival time was less than 12 months. As a non-invasive diagnostic technology, medical imaging consisting of computed tomography (CT) imaging, magnetic resonance imaging (MRI), and ultrasound (US) imaging, is the most effectively and commonly used method to detect CCA. The computer auxiliary diagnosis (CAD) system based on medical imaging is helpful for rapid diagnosis and provides credible \"second opinion\" for specialists. The purpose of this review is to categorize and review the CAD technique of detecting CCA based on medical imaging.
METHODS: This work applies a four-level screening process to choose suitable publications. 125 research papers published in different academic research databases were selected and analyzed according to specific criteria. From the five steps of medical image acquisition, processing, analysis, understanding and verification of CAD combined with artificial intelligence algorithms, we obtain the most advanced insights related to CCA detection.
RESULTS: This work provides a comprehensive analysis and comparison analysis of the current CAD systems of detecting CCA. After careful investigation, we find that the main detection methods are traditional machine learning method and deep learning method. For the detection, the most commonly used method is semi-automatic segmentation algorithm combined with support vector machine classifier method, combination of which has good detection performance. The end-to-end training mode makes deep learning method more and more popular in CAD systems. However, due to the limited medical training data, the accuracy of deep learning method is unsatisfactory.
CONCLUSIONS: Based on analysis of artificial intelligence methods applied in CCA, this work is expected to be truly applied in clinical practice in the future to improve the level of clinical diagnosis and treatment of it. This work concludes by providing a prediction of future trends, which will be of great significance for researchers in the medical imaging of CCA and artificial intelligence.

Computer-assisted orthopedic surgery (CAOS) systems have become one of the most important and challenging types of system in clinical orthopedics, as they enable precise treatment of musculoskeletal diseases, employing modern clinical navigation systems and surgical tools. This paper brings a comprehensive review of recent trends and possibilities of CAOS systems. There are three types of the surgical planning systems, including: systems based on the volumetric images (computer tomography (CT), magnetic resonance imaging (MRI) or ultrasound images), further systems utilize either 2D or 3D fluoroscopic images, and the last one utilizes the kinetic information about the joints and morphological information about the target bones. This complex review is focused on three fundamental aspects of CAOS systems: their essential components, types of CAOS systems, and mechanical tools used in CAOS systems. In this review, we also outline the possibilities for using ultrasound computer-assisted orthopedic surgery (UCAOS) systems as an alternative to conventionally used CAOS systems.