Medical Informatics

医学信息学
  • 文章类型: Review
    背景:健康信息技术(HIT)越来越多地用于实现健康服务/系统转换。大多数HIT实施在某种程度上都失败了;很少有人表现出可持续的成功。没有针对卫生服务领导者的指导方针来利用与成功相关的因素。本文的目的是为领导者提供一个基于证据的指南,以便在实践中进行测试和利用。
    方法:本指南是根据文献综述制定的,并通过对高级HIT角色人员的八次访谈来完善。进行了主题分析。它在第一作者的咨询工作中得到了完善,并在进行了少量改进后得到了确认。
    结果:确定了五个关键行动:关系,愿景,HIT系统属性,不断的评价和学习文化。
    结论:该指南为卫生系统领导者提供了一个重要的机会,可以在单个项目和区域/国家计划的实施过程中系统地检查相关的成功因素。
    BACKGROUND: Health information technology (HIT) is increasingly used to enable health service/system transformation. Most HIT implementations fail to some degree; very few demonstrate sustainable success. No guidelines exist for health service leaders to leverage factors associated with success. The purpose of this paper is to present an evidence-based guideline for leaders to test and leverage in practice.
    METHODS: This guideline was developed from a literature review and refined by a set of eight interviews with people in senior HIT roles, which were thematically analysed. It was refined in the consultancy work of the first author and confirmed after minor refinements.
    RESULTS: Five key actions were identified: relationships, vision, HIT system attributes, constant evaluation and learning culture.
    CONCLUSIONS: This guideline presents a significant opportunity for health system leaders to systematically check relevant success factors during the implementation process of single projects and regional/national programmes.
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  • 文章类型: Journal Article
    精确,可靠,需要具有成本效益并需要合理的实施时间和精力的有效指标来推动电子健康记录(EHR)的改进并减轻EHR负担。度量的研究和供应商定义之间存在差异。过程:我们召集了三个利益相关者团体(卫生系统信息学领导人,EHR供应商代表,和研究人员)在虚拟研讨会系列中就障碍达成共识,解决方案,以及实施核心EHR的后续步骤在动态护理中使用指标。结论:为解决EHR指标实施挑战的核心类别而确定的可行解决方案包括:(1)保持广泛的利益相关者参与,(2)跨供应商就标准化措施定义达成协议,(3)整合临床医生的观点,(4)解决认知和EHR负担。在本次研讨会产出的势头的基础上,为克服实施EHR使用指标的障碍提供了希望。
    Precise, reliable, valid metrics that are cost-effective and require reasonable implementation time and effort are needed to drive electronic health record (EHR) improvements and decrease EHR burden. Differences exist between research and vendor definitions of metrics. PROCESS:  We convened three stakeholder groups (health system informatics leaders, EHR vendor representatives, and researchers) in a virtual workshop series to achieve consensus on barriers, solutions, and next steps to implementing the core EHR use metrics in ambulatory care. CONCLUSION:  Actionable solutions identified to address core categories of EHR metric implementation challenges include: (1) maintaining broad stakeholder engagement, (2) reaching agreement on standardized measure definitions across vendors, (3) integrating clinician perspectives, and (4) addressing cognitive and EHR burden. Building upon the momentum of this workshop\'s outputs offers promise for overcoming barriers to implementing EHR use metrics.
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  • 文章类型: Journal Article
    背景本研究旨在评估ChatGPT的疗效,先进的自然语言处理模型,通过比较和对比不同的指南来源来适应和综合糖尿病酮症酸中毒(DKA)的临床指南。方法我们采用了全面的比较方法,并检查了三个著名的指南来源:加拿大糖尿病临床实践指南专家委员会(2018),初级保健中高血糖的应急管理,联合英国糖尿病协会(JBDS)02成人糖尿病酮症酸中毒的管理。数据提取侧重于诊断标准,危险因素,症状和体征,调查,和治疗建议。我们比较了ChatGPT生成的综合指南,并确定了任何误报或未报告的错误。结果ChatGPT能够生成比较指南的综合表格。然而,多个反复出现的错误,包括误报和未报告错误,被确认,使结果不可靠。此外,在重复报告数据中观察到不一致.该研究强调了使用ChatGPT在没有专家人工干预的情况下适应临床指南的局限性。结论虽然ChatGPT证明了临床指南合成的潜力,多次反复出现的错误和不一致现象的存在凸显了专家人工干预和验证的必要性.未来的研究应该集中在提高ChatGPT的准确性和可靠性上,以及探索其在临床实践和指南开发其他领域的潜在应用。
    Background This study aimed to evaluate the efficacy of ChatGPT, an advanced natural language processing model, in adapting and synthesizing clinical guidelines for diabetic ketoacidosis (DKA) by comparing and contrasting different guideline sources. Methodology We employed a comprehensive comparison approach and examined three reputable guideline sources: Diabetes Canada Clinical Practice Guidelines Expert Committee (2018), Emergency Management of Hyperglycaemia in Primary Care, and Joint British Diabetes Societies (JBDS) 02 The Management of Diabetic Ketoacidosis in Adults. Data extraction focused on diagnostic criteria, risk factors, signs and symptoms, investigations, and treatment recommendations. We compared the synthesized guidelines generated by ChatGPT and identified any misreporting or non-reporting errors. Results ChatGPT was capable of generating a comprehensive table comparing the guidelines. However, multiple recurrent errors, including misreporting and non-reporting errors, were identified, rendering the results unreliable. Additionally, inconsistencies were observed in the repeated reporting of data. The study highlights the limitations of using ChatGPT for the adaptation of clinical guidelines without expert human intervention. Conclusions Although ChatGPT demonstrates the potential for the synthesis of clinical guidelines, the presence of multiple recurrent errors and inconsistencies underscores the need for expert human intervention and validation. Future research should focus on improving the accuracy and reliability of ChatGPT, as well as exploring its potential applications in other areas of clinical practice and guideline development.
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  • 文章类型: Journal Article
    当早期发现并适当管理癌前病变时,宫颈癌是高度可预防的。然而,现有循证临床指南的复杂性和频繁更新使得临床医生掌握最新建议具有挑战性.此外,信息技术(IT)决策支持的可用性和可及性有限,使得医疗服务不足的群体很难接受筛查或接受适当的后续护理.疾病控制和预防中心(CDC),癌症预防和控制司(DCPC),正在领导一项多年计划,以开发现有循证指南的计算机可解释(“可计算”)版本,以支持临床医生对最新宫颈癌筛查和管理指南的认识和采用。DCPC正在与MITRE公司合作,国家癌症研究所的顶尖科学家,和其他CDC主题专家将现有的叙述指南转化为可计算格式,并开发临床决策支持工具,以集成到健康IT系统中,例如电子健康记录,最终目标是改善患者预后并减少医疗服务不足的人群中宫颈癌预后的差异。该倡议满足了总统癌症小组和总统癌症登月2.0所强调的挑战和机遇,以几乎消除宫颈癌。
    Cervical cancer is highly preventable when precancerous lesions are detected early and appropriately managed. However, the complexity of and frequent updates to existing evidence-based clinical guidelines make it challenging for clinicians to stay abreast of the latest recommendations. In addition, limited availability and accessibility to information technology (IT) decision supports make it difficult for groups who are medically underserved to receive screening or receive the appropriate follow-up care. The Centers for Disease Control and Prevention (CDC), Division of Cancer Prevention and Control (DCPC), is leading a multiyear initiative to develop computer-interpretable (\"computable\") version of already existing evidence-based guidelines to support clinician awareness and adoption of the most up-to-date cervical cancer screening and management guidelines. DCPC is collaborating with the MITRE Corporation, leading scientists from the National Cancer Institute, and other CDC subject matter experts to translate existing narrative guidelines into computable format and develop clinical decision support tools for integration into health IT systems such as electronic health records with the ultimate goal of improving patient outcomes and decreasing disparities in cervical cancer outcomes among populations that are medically underserved. This initiative meets the challenges and opportunities highlighted by the President\'s Cancer Panel and the President\'s Cancer Moonshot 2.0 to nearly eliminate cervical cancer.
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  • 文章类型: Journal Article
    目的:美国心脏病学会和美国心脏协会动脉粥样硬化性心血管疾病(ASCVD)一级预防指南推荐使用10年ASCVD风险评估模型来启动他汀类药物治疗。对于准则一致的决策,风险估计需要校准。然而,现有的模型经常针对种族进行错误校准,基于种族和性别的亚组。本研究评估了两种算法公平性方法,以调整风险估计器(组重新校准和均衡赔率),使其与指导准则决策规则的假设兼容。方法使用更新的汇总队列数据集,我们推导出无约束,10年ASCVD风险估计器的组重新校准和均衡赔率约束版本,并将它们的校准值与指南一致的决策阈值进行比较。
    结果:我们发现,与无约束模型相比,组重新校准改进了每个组的相关阈值之一的校准,但加剧了组间假阳性和假阴性率的差异。均衡赔率约束,旨在均衡各组的错误率,这样做是通过错误校准整个模型和相关的决策阈值。
    结论:因此,由于诱发的校准错误,由风险估计器指导的决策与均衡的赔率公平约束不一致的现有准则。相反,为每个组分别重新校准模型可以增加指南兼容性,同时增加了错误率的组间差异。因此,当指南建议以固定的决策阈值进行治疗时,组间错误率的比较可能会产生误导.
    结论:说明的满足公平性标准和保持指南兼容性之间的权衡强调了在下游干预背景下评估模型的必要性。
    OBJECTIVE: The American College of Cardiology and the American Heart Association guidelines on primary prevention of atherosclerotic cardiovascular disease (ASCVD) recommend using 10-year ASCVD risk estimation models to initiate statin treatment. For guideline-concordant decision-making, risk estimates need to be calibrated. However, existing models are often miscalibrated for race, ethnicity and sex based subgroups. This study evaluates two algorithmic fairness approaches to adjust the risk estimators (group recalibration and equalised odds) for their compatibility with the assumptions underpinning the guidelines\' decision rules.MethodsUsing an updated pooled cohorts data set, we derive unconstrained, group-recalibrated and equalised odds-constrained versions of the 10-year ASCVD risk estimators, and compare their calibration at guideline-concordant decision thresholds.
    RESULTS: We find that, compared with the unconstrained model, group-recalibration improves calibration at one of the relevant thresholds for each group, but exacerbates differences in false positive and false negative rates between groups. An equalised odds constraint, meant to equalise error rates across groups, does so by miscalibrating the model overall and at relevant decision thresholds.
    CONCLUSIONS: Hence, because of induced miscalibration, decisions guided by risk estimators learned with an equalised odds fairness constraint are not concordant with existing guidelines. Conversely, recalibrating the model separately for each group can increase guideline compatibility, while increasing intergroup differences in error rates. As such, comparisons of error rates across groups can be misleading when guidelines recommend treating at fixed decision thresholds.
    CONCLUSIONS: The illustrated tradeoffs between satisfying a fairness criterion and retaining guideline compatibility underscore the need to evaluate models in the context of downstream interventions.
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  • 文章类型: Journal Article
    身体功能与重要结果相关,然而,常规评估往往缺乏连续性。这项研究的目的是确定数据元素和工具,用于从急性护理医院过渡到家庭和家庭保健的患者在常规护理中对身体功能进行纵向测量。
    对13名具有物理治疗专业知识的参与者进行了4轮改良Delphi过程,卫生保健管理,卫生服务研究,理疗/医学,和健康信息学。三个匿名轮确定了重要且可行的数据元素。第四轮亲自完成了建议的单个数据元素列表。接下来,2个焦点小组独立提供了其他利益相关者的额外观点。
    在线第1、3和4轮的反应率为100%,第2轮的反应率为92%。在第1轮中,确定了9个结构域:身体功能,参与,不良事件,行为/情绪健康,社会支持,认知,疾病/疾病负担的复杂性,医疗保健利用,和人口统计。第四轮之后,建议使用27个单独的数据元素。其中,20(74%)是“行政”,可从大多数医院电子病历中获得。其他焦点小组确认了这些选择,并提供了有关标准化收集方法的输入。已经开发了一个网站来分享这些结果,并邀请其他医疗保健系统参与这些已识别数据元素的未来数据共享。
    使用改进的Delphi共识过程来识别关键数据元素,以跟踪患者在常规护理中从急性医院过渡到家庭健康时身体功能的变化。
    关于在常规护理中全面可行地测量身体机能的专家共识,为卫生保健专业人员和机构提供了建立离散医疗记录数据的指导,这些数据可以改善患者护理,出院决定,和未来的研究。
    Physical function is associated with important outcomes, yet there is often a lack of continuity in routine assessment. The purpose of this study was to determine data elements and instruments for longitudinal measurement of physical function in routine care among patients transitioning from acute care hospital setting to home with home health care.
    A 4-round modified Delphi process was conducted with 13 participants with expertise in physical therapy, health care administration, health services research, physiatry/medicine, and health informatics. Three anonymous rounds identified important and feasible data elements. A fourth in-person round finalized the recommended list of individual data elements. Next, 2 focus groups independently provided additional perspectives from other stakeholders.
    Response rates were 100% for online rounds 1, 3, and 4 and 92% for round 2. In round 1, 9 domains were identified: physical function, participation, adverse events, behavioral/emotional health, social support, cognition, complexity of illness/disease burden, health care utilization, and demographics. Following the fourth round, 27 individual data elements were recommended. Of these, 20 (74%) are \"administrative\" and available from most hospital electronic medical records. Additional focus groups confirmed these selections and provided input on standardizing collection methods. A website has been developed to share these results and invite other health care systems to participate in future data sharing of these identified data elements.
    A modified Delphi consensus process was used to identify critical data elements to track changes in patient physical function in routine care as they transition from acute hospital to home with home health.
    Expert consensus on comprehensive and feasible measurement of physical function in routine care provides health care professionals and institutions with guidance in establishing discrete medical records data that can improve patient care, discharge decisions, and future research.
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  • 文章类型: Journal Article
    认证是评估和监控过程,确保教育计划和机构符合学术标准和运营诚信和质量。生物医学和健康信息学领域的程序数量正在迅速增加。在本文中,我们简要介绍了由欧洲医学信息学联合会认证委员会(AC2)根据国际标准建立的认证程序。
    Accreditation is the evaluation and monitoring process assuring that educational programs and institutions meet academic standards and operational integrity and quality. The number of programs in the field of Biomedical and Health Informatics is rapidly increasing. In this paper we briefly introduce the accreditation procedure that has been established by Accreditation Committee (AC2) of European Federation of Medical Informatics according to international standards.
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  • 文章类型: Journal Article
    心血管疾病是儿童癌症幸存者晚期发病和死亡的重要原因。临床信息学工具可以增强提供者对超声心动图指南的依从性,以早期发现迟发性心肌病。
    癌症登记数据与电子健康记录数据相关联。结构化查询语言有助于在单个机构中构建蒽环类抗生素暴露队列。主要结果包括自动蒽环类抗生素提取的数据质量,国际疾病分类对心力衰竭编码的敏感性,和坚持超声心动图指南建议。
    最终分析队列包括在2013年7月1日至2018年12月31日之间诊断的385名儿科肿瘤患者,其中194名被归类为无蒽环类药物暴露。143例蒽环类药物暴露量较低(<250mg/m2),48例蒽环类药物暴露量较高(≥250mg/m2)。蒽环类抗生素暴露的手动检查与自动提取高度一致(95%)。在未曝光的群体中,15%的人在未通过标准查询语言编码捕获的外部机构使用蒽环类抗生素。超声心动图参数和临床记录的手动检查灵敏度为75%,特异性98%,心力衰竭的国际疾病分类编码的阳性预测值为68%。对于蒽环类药物暴露的患者,78.5%(n=62)遵守超声心动图监测的指南建议。与提供者依从性和种族和民族有显著关联(P=0.047),50%的以西班牙语为主要语言的患者与90%的以英语为主要语言的患者(P=.003)。
    通过临床信息学从电子健康记录中提取治疗暴露量,并与癌症登记数据进行整合,是评估心血管疾病预后和坚持幸存者指南建议的可行方法。
    Cardiovascular disease is a significant cause of late morbidity and mortality in survivors of childhood cancer. Clinical informatics tools could enhance provider adherence to echocardiogram guidelines for early detection of late-onset cardiomyopathy.
    Cancer registry data were linked to electronic health record data. Structured query language facilitated the construction of anthracycline-exposed cohorts at a single institution. Primary outcomes included the data quality from automatic anthracycline extraction, sensitivity of International Classification of Disease coding for heart failure, and adherence to echocardiogram guideline recommendations.
    The final analytic cohort included 385 pediatric oncology patients diagnosed between July 1, 2013, and December 31, 2018, among whom 194 were classified as no anthracycline exposure, 143 had low anthracycline exposure (< 250 mg/m2), and 48 had high anthracycline exposure (≥ 250 mg/m2). Manual review of anthracycline exposure was highly concordant (95%) with the automatic extraction. Among the unexposed group, 15% had an anthracycline administered at an outside institution not captured by standard query language coding. Manual review of echocardiogram parameters and clinic notes yielded a sensitivity of 75%, specificity of 98%, and positive predictive value of 68% for International Classification of Disease coding of heart failure. For patients with anthracycline exposure, 78.5% (n = 62) were adherent to guideline recommendations for echocardiogram surveillance. There were significant association with provider adherence and race and ethnicity (P = .047), and 50% of patients with Spanish as their primary language were adherent compared with 90% of patients with English as their primary language (P = .003).
    Extraction of treatment exposures from the electronic health record through clinical informatics and integration with cancer registry data represents a feasible approach to assess cardiovascular disease outcomes and adherence to guideline recommendations for survivors.
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  • 文章类型: Journal Article
    随着卫生信息技术(HIT)的普及,越来越需要了解与使用此类工具相关的潜在隐私风险。尽管隐私政策旨在告知消费者,这些政策一直被发现令人困惑,缺乏透明度。
    这项研究旨在呈现消费者对获取隐私信息的偏好;开发和应用隐私政策风险评估工具,以评估现有HIT是否符合建议的隐私政策标准;并提出指导方针,以协助卫生专业人员和服务提供商了解与HIT相关的隐私风险,这样他们就可以自信地促进他们的安全使用,作为护理的一部分。
    在第一阶段,参与式设计研讨会与参加活动的顶部空间中心的年轻人进行。他们支持的其他人,以及中心的卫生专业人员和服务提供者。对调查结果进行了知识翻译,以确定参与者对隐私信息的呈现和可用性以及支持其交付所需的功能的偏好。第二阶段包括开发23项隐私政策风险评估工具,其中纳入了国际隐私文献和标准的材料。然后,该工具用于评估34个应用程序和电子工具的隐私政策。在第三阶段,隐私指南,这是从与关键利益相关者的合作协商过程中学到的,旨在帮助卫生专业人员和服务提供商了解与将HIT纳入临床护理相关的隐私风险。
    在考虑使用HIT时,参与式设计研讨会参与者表示,他们希望隐私信息易于访问,透明,并且用户友好,使他们能够清楚地了解将收集哪些个人和健康信息以及如何共享和存储这些数据。隐私政策审查显示,可读性和透明度一直很差,这限制了这些文档作为信息来源的效用。因此,为了实现知情同意,提供的隐私准则确保卫生专业人员和消费者充分意识到使用HIT来支持健康和福祉的潜在隐私风险。
    隐私政策缺乏透明度,有可能削弱消费者相信已经采取必要措施来保护和保护其个人和健康信息的隐私的能力。从而排除了他们与HIT接触的意愿。隐私准则的应用将提高卫生专业人员和服务提供者对消费者数据隐私的信心,从而使他们能够推荐HIT提供或支持护理。
    Along with the proliferation of health information technologies (HITs), there is a growing need to understand the potential privacy risks associated with using such tools. Although privacy policies are designed to inform consumers, such policies have consistently been found to be confusing and lack transparency.
    This study aims to present consumer preferences for accessing privacy information; develop and apply a privacy policy risk assessment tool to assess whether existing HITs meet the recommended privacy policy standards; and propose guidelines to assist health professionals and service providers with understanding the privacy risks associated with HITs, so that they can confidently promote their safe use as a part of care.
    In phase 1, participatory design workshops were conducted with young people who were attending a participating headspace center, their supportive others, and health professionals and service providers from the centers. The findings were knowledge translated to determine participant preferences for the presentation and availability of privacy information and the functionality required to support its delivery. Phase 2 included the development of the 23-item privacy policy risk assessment tool, which incorporated material from international privacy literature and standards. This tool was then used to assess the privacy policies of 34 apps and e-tools. In phase 3, privacy guidelines, which were derived from learnings from a collaborative consultation process with key stakeholders, were developed to assist health professionals and service providers with understanding the privacy risks associated with incorporating HITs as a part of clinical care.
    When considering the use of HITs, the participatory design workshop participants indicated that they wanted privacy information to be easily accessible, transparent, and user-friendly to enable them to clearly understand what personal and health information will be collected and how these data will be shared and stored. The privacy policy review revealed consistently poor readability and transparency, which limited the utility of these documents as a source of information. Therefore, to enable informed consent, the privacy guidelines provided ensure that health professionals and consumers are fully aware of the potential for privacy risks in using HITs to support health and well-being.
    A lack of transparency in privacy policies has the potential to undermine consumers\' ability to trust that the necessary measures are in place to secure and protect the privacy of their personal and health information, thus precluding their willingness to engage with HITs. The application of the privacy guidelines will improve the confidence of health professionals and service providers in the privacy of consumer data, thus enabling them to recommend HITs to provide or support care.
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  • 文章类型: Journal Article
    高质量的研究对于指导循证护理至关重要,并且应该以可重复的方式报告,透明,在适当的情况下,为纳入未来的荟萃分析提供足够的细节。各种研究设计的报告指南已广泛用于临床(和临床前)研究,由包含最小点集的清单组成。随着最近使用人工智能(AI)的研究数量的增加,需要评估其他因素,不完全符合传统的报告准则(例如,与技术算法开发相关的详细信息)。在这次审查中,强调报告指南,以提高对评估医疗保健中AI干预研究所需的基本内容的认识。其中包括已发布和正在进行的对众所周知的报告指南的扩展,例如标准协议项目:对介入试验的建议-AI(研究协议),报告试验综合标准-AI(随机对照试验),诊断准确性研究报告标准-AI(诊断准确性研究)和个人预后或诊断多变量预测模型的透明报告-AI(预测模型研究)。此外,还有许多指南更广泛地考虑将人工智能用于健康干预(例如,医学影像人工智能清单(CLAIM),最小信息(MI)-索赔,用于医疗AI报告的MI)或解决特定元素,例如“学习曲线”(决策AI的发展和探索性临床研究)。人工智能健康干预措施的经济评估目前尚未解决,并可能受益于现有准则的扩展。面对AI健康干预研究的迅速涌入,报告指南有助于确保研究人员和评估研究人员同时考虑良好研究设计和报告的公认要素,同时也充分应对AI特定元素带来的新挑战。
    High-quality research is essential in guiding evidence-based care, and should be reported in a way that is reproducible, transparent and where appropriate, provide sufficient detail for inclusion in future meta-analyses. Reporting guidelines for various study designs have been widely used for clinical (and preclinical) studies, consisting of checklists with a minimum set of points for inclusion. With the recent rise in volume of research using artificial intelligence (AI), additional factors need to be evaluated, which do not neatly conform to traditional reporting guidelines (eg, details relating to technical algorithm development). In this review, reporting guidelines are highlighted to promote awareness of essential content required for studies evaluating AI interventions in healthcare. These include published and in progress extensions to well-known reporting guidelines such as Standard Protocol Items: Recommendations for Interventional Trials-AI (study protocols), Consolidated Standards of Reporting Trials-AI (randomised controlled trials), Standards for Reporting of Diagnostic Accuracy Studies-AI (diagnostic accuracy studies) and Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis-AI (prediction model studies). Additionally there are a number of guidelines that consider AI for health interventions more generally (eg, Checklist for Artificial Intelligence in Medical Imaging (CLAIM), minimum information (MI)-CLAIM, MI for Medical AI Reporting) or address a specific element such as the \'learning curve\' (Developmental and Exploratory Clinical Investigation of Decision-AI) . Economic evaluation of AI health interventions is not currently addressed, and may benefit from extension to an existing guideline. In the face of a rapid influx of studies of AI health interventions, reporting guidelines help ensure that investigators and those appraising studies consider both the well-recognised elements of good study design and reporting, while also adequately addressing new challenges posed by AI-specific elements.
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