炎症蛋白激活血小板,已观察到与癌症进展和发展直接相关。本系统综述的目的是探讨平均血小板体积(MPV)与癌症(MPV的诊断能力,关系到生存,疾病的严重程度,和转移)。在2010-2022年期间的在线数据库PubMed和GoogleScholar中进行了文献综述。总的来说,83项研究,包括21,034名患有12种不同类型癌症的参与者(即,胃癌,结肠癌,食管鳞状细胞癌,肾癌,乳腺癌,卵巢癌,子宫内膜癌,甲状腺癌,肺癌,膀胱癌,胆囊癌,和多发性骨髓瘤)被鉴定。MPV在几种癌症中的作用已被广泛研究,比如胃,结肠,乳房,肺癌,虽然其他类型的数据很少,比如肾,胆囊癌,和多发性骨髓瘤.大多数胃病研究,乳房,子宫内膜,甲状腺,肺癌患者的MPV升高。食道数据不太明确,卵巢,结肠癌,在肾细胞癌和胆囊癌中观察到MPV降低。一些关于结肠癌的研究(6个中的4个)和关于肺癌的研究较少(10个中的4个)表明MPV增加对死亡率的不利作用。至于其他类型的癌症,进行的研究较少。MPV可以用作癌症诊断中的潜在生物标志物,并且可能是优化治疗策略的有用工具。讨论了癌症和MPV之间可能的潜在机制。然而,需要进一步的研究来阐明MPV在癌症进展和转移中的确切作用.
Inflammatory proteins activate platelets, which have been observed to be directly related to cancer progression and development. The aim of this systematic
review is to investigate the possible association between Mean Platelet Volume (MPV) and cancer (diagnostic capacity of MPV, relation to survival, the severity of the disease, and metastasis). A literature
review was performed in the online database PubMed and Google Scholar for the period of 2010-2022. In total, 83 studies including 21,034 participants with 12 different types of cancer (i.e., gastric cancer, colon cancer, esophageal squamous cell carcinoma, renal cancer, breast cancer, ovarian cancer, endometrial cancer, thyroid cancer, lung cancer, bladder cancer, gallbladder cancer, and multiple myeloma) were identified. The role of MPV has been extensively investigated in several types of cancer, such as gastric, colon, breast, and lung cancer, while few data exist for other types, such as renal, gallbladder cancer, and multiple myeloma. Most studies in gastric, breast, endometrium, thyroid, and lung cancer documented an elevated MPV in cancer patients. Data were less clear-cut for esophageal, ovarian, and colon cancer, while reduced MPV was observed in renal cell carcinoma and gallbladder cancer. Several studies on colon cancer (4 out of 6) and fewer on lung cancer (4 out of 10) indicated an unfavorable role of increased MPV regarding mortality. As far as other cancer types are concerned, fewer studies were conducted. MPV can be used as a potential biomarker in cancer diagnosis and could be a useful tool for the optimization of treatment strategies. Possible underlying mechanisms between cancer and MPV are discussed. However, further studies are needed to elucidate the exact role of MPV in cancer progression and metastasis.