PDF(Pubmed)
Abstract：
UNASSIGNED: Immature Platelet Fraction (IPF) is a measure of the proportion of reticulated platelets (RPs) to all platelets in circulation. IPF may have both prognostic and diagnostic values in patients with Acute Coronary Syndrome (ACS). This study aims to comprehensively summarize the diagnostic utility of IPF levels in patients with ACS, specifically focusing on its ability to differentiate between different subtypes of ACS.
UNASSIGNED: We conducted a systematic search in online databases including MEDLINE, Scopus, and Google Scholar up to March 4th 2024, to identify relevant studies. The random-effect model, employing inverse variance for mean differences (MD) and Mantel-Haenszel methods for odds ratios (OR) were utilized to combine the data. Joanna Briggs Institute (JBI) appraisal tool was employed to assess the quality of included studies.
UNASSIGNED: Our systematic review contains 15 articles with a total sample size of 2,030 ACS patients. Pooled analysis revealed significant differences in IPF levels of ACS patients compared to healthy controls (MD (95%CI): 2.85 (0.86, 4.85), P-value = 0.004) and stable angina patients (MD (95%CI): 0.58 (0.23, 0.92), P-value < 0.001). Subgroup comparisons within ACS patients demonstrated higher IPF levels in myocardial infarction (MI) vs. unstable angina (UA) (MD (95%CI): 1.81 (0.41, 3.22), P-value = 0.01), ST elevation MI (STEMI) vs. non-ST elevation (NSTEMI) ACS (MD (95%CI): 0.74 (0.31, 1.17), P-value < 0.001), and NSTEMI vs. UA (MD (95% CI): 1.07 (0.24, 1.90), P-value = 0.01).
UNASSIGNED: IPF levels could increase in patients with ACS, particularly during the acute phase of STEMI. This suggests that IPF may be a useful biomarker for early diagnosis of ACS. Additionally, IPF levels may help differentiate between ACS subtypes.
UNASSIGNED: We conducted a systematic search in online databases including MEDLINE, Scopus, and Google Scholar up to March 4th 2024, to identify relevant studies. The random-effect model, employing inverse variance for mean differences (MD) and Mantel-Haenszel methods for odds ratios (OR) were utilized to combine the data. Joanna Briggs Institute (JBI) appraisal tool was employed to assess the quality of included studies.
UNASSIGNED: Our systematic review contains 15 articles with a total sample size of 2,030 ACS patients. Pooled analysis revealed significant differences in IPF levels of ACS patients compared to healthy controls (MD (95%CI): 2.85 (0.86, 4.85), P-value = 0.004) and stable angina patients (MD (95%CI): 0.58 (0.23, 0.92), P-value < 0.001). Subgroup comparisons within ACS patients demonstrated higher IPF levels in myocardial infarction (MI) vs. unstable angina (UA) (MD (95%CI): 1.81 (0.41, 3.22), P-value = 0.01), ST elevation MI (STEMI) vs. non-ST elevation (NSTEMI) ACS (MD (95%CI): 0.74 (0.31, 1.17), P-value < 0.001), and NSTEMI vs. UA (MD (95% CI): 1.07 (0.24, 1.90), P-value = 0.01).
UNASSIGNED: IPF levels could increase in patients with ACS, particularly during the acute phase of STEMI. This suggests that IPF may be a useful biomarker for early diagnosis of ACS. Additionally, IPF levels may help differentiate between ACS subtypes.
摘要：
未成熟血小板分数(IPF)是循环中网状血小板(RP)与所有血小板的比例的量度。IPF对急性冠脉综合征（ACS）患者可能具有预后和诊断价值。本研究旨在全面总结ACS患者IPF水平的诊断价值,特别关注其区分不同ACS亚型的能力。
■我们在包括MEDLINE在内的在线数据库中进行了系统的搜索，Scopus,和截至2024年3月4日的谷歌学者，以确定相关研究。随机效应模型，采用平均差(MD)的逆方差和比值比(OR)的Mantel-Haenszel方法来合并数据.采用乔安娜·布里格斯研究所（JBI）评估工具来评估纳入研究的质量。
■我们的系统评价包含15篇文章，总样本量为2,030名ACS患者。汇总分析显示，与健康对照组相比，ACS患者的IPF水平存在显着差异（MD（95CI）：2.85（0.86，4.85），P值=0.004）和稳定型心绞痛患者（MD（95CI）：0.58（0.23，0.92），P值<0.001)。ACS患者的亚组比较显示，心肌梗死（MI）的IPF水平高于不稳定型心绞痛（UA）（MD（95CI）：1.81（0.41，3.22），P值=0.01)，ST段抬高MI(STEMI)与非ST段抬高（NSTEMI）ACS（MD（95CI）：0.74（0.31，1.17），P值<0.001)，和NSTEMIvs.UA（MD（95%CI）：1.07（0.24，1.90），P值=0.01)。
■ACS患者的IPF水平可能会增加，特别是在STEMI的急性期。这表明IPF可能是早期诊断ACS的有用生物标志物。此外,IPF水平可能有助于区分ACS亚型。
■我们在包括MEDLINE在内的在线数据库中进行了系统的搜索，Scopus,和截至2024年3月4日的谷歌学者，以确定相关研究。随机效应模型，采用平均差(MD)的逆方差和比值比(OR)的Mantel-Haenszel方法来合并数据.采用乔安娜·布里格斯研究所（JBI）评估工具来评估纳入研究的质量。
■我们的系统评价包含15篇文章，总样本量为2,030名ACS患者。汇总分析显示，与健康对照组相比，ACS患者的IPF水平存在显着差异（MD（95CI）：2.85（0.86，4.85），P值=0.004）和稳定型心绞痛患者（MD（95CI）：0.58（0.23，0.92），P值<0.001)。ACS患者的亚组比较显示，心肌梗死（MI）的IPF水平高于不稳定型心绞痛（UA）（MD（95CI）：1.81（0.41，3.22），P值=0.01)，ST段抬高MI(STEMI)与非ST段抬高（NSTEMI）ACS（MD（95CI）：0.74（0.31，1.17），P值<0.001)，和NSTEMIvs.UA（MD（95%CI）：1.07（0.24，1.90），P值=0.01)。
■ACS患者的IPF水平可能会增加，特别是在STEMI的急性期。这表明IPF可能是早期诊断ACS的有用生物标志物。此外,IPF水平可能有助于区分ACS亚型。
