目的:我们旨在探讨与婴儿先天性心脏病风险相关的母系和父系危险因素。
方法:长治医学院附属和平医院收治的先天性心脏病(CHD)婴儿125例,对照组125例,山西,中国。在本研究中,受试者在2016年1月1日至2021年12月31日之间被诊断出。所有特征均采用面对面访谈的方式进行问卷调查,包括母亲和父亲的危险因素。采用条件logistic回归分析婴幼儿先天性心脏病的危险因素。
结果:对于孕产妇风险因素,我们发现年龄,怀孕次数,收缩压(SBP),舒张压(DBP),和体重指数(BMI)是CHD婴儿的危险因素,年龄的ORs(95CIs)为1.15(1.06-1.23),SBP为1.13(1.02-1.29),1.06(1.02-1.18)DBP,BMI为1.22(1.16-1.31)。与一次怀孕相比,两次妊娠的ORs(95CI)为1.17(1.05~1.29),更多妊娠的ORs为1.25(1.16~1.47).对于父亲的危险因素,我们发现年龄(OR=1.07,95CI=1.01-1.19),吸烟(OR=1.11,95CI=1.03-1.27),饮酒(OR=1.04,95CI=1.02-1.19),BMI(OR=1.15,95CI=1.03-1.28)是CHD婴儿的危险因素。
结论:我们发现年龄,怀孕次数,SBP,DBP,和BMI是CHD婴儿的母体危险因素。和年龄,吸烟,饮酒,BMI是CHD婴儿的父系危险因素。
OBJECTIVE: We aimed to explore
maternal and paternal risk factors with risk of congenital heart disease in infants.
METHODS: A total of 125 congenital heart disease (CHD) infants and 125 controls were included in Heping Hospital Affiliated to Changzhi Medical College, Shanxi, China. Subjects were diagnosed between Jan 1, 2016 and Dec 31, 2021 in the present study. All the characteristics were collected with questionnaire by face-to-face interview, including
maternal and paternal risk factors. Conditional logistic regression was conducted to explore the risk factors with risk of congenital heart disease in infants.
RESULTS: For
maternal risk factors, we found that age, number of pregnancies, systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI) were risk factors for CHD infants, and the ORs (95%CIs) were 1.15 (1.06-1.23) for age, 1.13 (1.02-1.29) for SBP, 1.06 (1.02-1.18) for DBP, 1.22 (1.16-1.31) for BMI. Compared with one pregnancy, the ORs (95%CIs) were 1.17 (1.05-1.29) for two pregnancies and 1.25 (1.16-1.47) for more pregnancies. For paternal risk factors, we found that age (OR = 1.07, 95%CI = 1.01-1.19), smoking (OR = 1.11, 95%CI = 1.03-1.27), drinking (OR = 1.04, 95%CI = 1.02-1.19), and BMI (OR = 1.15, 95%CI = 1.03-1.28) were risk factors for CHD infants.
CONCLUSIONS: We found that age, number of pregnancies, SBP, DBP, and BMI are
maternal risk factors for CHD infants. And age, smoking, drinking, and BMI are paternal risk factors for CHD infants.