背景:帕金森病(PD)患者在执行日常口面功能方面面临的困难和挑战尚未得到系统研究。在这项研究中,与匹配的对照组相比,对PD患者的特定口面非运动和运动症状和功能进行了系统检查.
方法:临床病例对照研究于2021年5月至2022年10月进行,包括患有PD的人和年龄和性别匹配的无PD的人。患有PD的参与者是在哥本哈根Bispebjerg大学医院神经内科诊断为PD的门诊患者,丹麦。参与者对口面部功能和颞下颌关节紊乱病(TMD)进行了系统的临床和相关的自我评估。主要结果是对总体口面功能的客观和主观评估,咀嚼,吞咽,口干症和流口水.次要结果是TMD和口面部疼痛的患病率。使用卡方检验和Mann-WhitneyU检验分析两组之间结果测量值的差异。
结果:该研究包括20名PD患者和20名年龄和性别匹配的无PD患者。无论是客观的还是主观的,PD患者的口面部功能比对照组差.患有PD的人对下颌活动和下颌功能的限制也更加严重。与对照组相比,PD患者的客观咀嚼功能也显着降低,60%的PD患者发现很难食用具有一定一致性的食物,而0%的对照组报告了这一问题。患有PD的人每秒可以吞咽更少的水,并且PD人的平均吞咽事件明显更长。尽管PD患者报告口干症较多(PD患者为58%,对照组为20%),他们还报告了比对照组明显更多的流口水。此外,口面疼痛在PD患者中更为普遍。
结论:PD患者的口面部功能受损。此外,该研究表明PD和口面部疼痛之间存在联系。为了相应地筛查和治疗患有PD的人,医疗保健专业人员应该意识到并解决这些限制和症状。
背景:该试验获得了首都地区研究健康伦理区域委员会的批准(H-20,047,464),丹麦数据保护局(514-0510/20-3000),并在ClinicalTrials.gov(NCT05356845)注册。
The difficulties and challenges faced by people with Parkinson\'s disease (PD) in performing daily orofacial function are not systematically investigated. In this study, specific orofacial non-motor and motor symptoms and functions were systematically examined in PD patients in comparison to a matched control group.
The clinical
case-controlled study was conducted from May 2021 to October 2022 and included persons with PD and age- and gender-matched persons without PD. The participants with PD were outpatients diagnosed with PD at the Department of Neurology at Bispebjerg University Hospital in Copenhagen, Denmark. The participants underwent a systematic clinical and relevant self-assessment of the orofacial function and temporomandibular disorders (TMD). The primary outcomes were objective and subjective assessments of the general orofacial function,
mastication, swallowing, xerostomia and drooling. The secondary outcomes were the prevalence of TMD and orofacial pain. The difference in outcome measures between the two groups was analysed using chi-square and Mann-Whitney U test.
The study included 20 persons with PD and 20 age- and gender-matched persons without PD. Both objectively and subjectively, persons with PD had poorer orofacial function than the control group. Persons with PD had also a significantly more severe limitation of jaw mobility and jaw function. The objective masticatory function was also significantly reduced for persons with PD compared to the control group, and 60% of persons with PD found it difficult to eat foods with certain consistencies while 0% of the control group reported that problem. Persons with PD could swallow less water per second and the average swallowing event was significantly longer for PD persons. Even though PD persons reported more xerostomia (58% for persons with PD and 20% for control persons), they also reported significantly more drooling than the control group. Additionally, orofacial pain was more prevalent in PD persons.
Persons with PD have a compromised orofacial function. Furthermore, the study indicates a link between PD and orofacial pain. In order to screen and treat persons with PD accordingly, healthcare professionals should be aware of and address these limitations and symptoms.
The trial was approved by the Regional Committee on Research Health Ethics of the Capital Region (H-20,047,464), the Danish Data Protection Agency (514 - 0510/20-3000), and registered at ClinicalTrials.gov (NCT05356845).