Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway\'s contribution to the development and progression of neuroblastoma. This review compiles up-to-date evidence of this pathway\'s involvement in neuroblastoma. We discuss the RAS-MAPK pathway\'s general functioning, the clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling.