神经母细胞瘤 RAS - MAPK 通路改变的生物学和临床意义综述。A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma.-医云文献数字医云科研云海量医学决策数据服务

Abstract：

Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway\'s contribution to the development and progression of neuroblastoma. This review compiles up-to-date evidence of this pathway\'s involvement in neuroblastoma. We discuss the RAS-MAPK pathway\'s general functioning, the clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling.

摘要：

神经母细胞瘤是儿童最常见的颅外实体瘤,约占所有儿童恶性肿瘤的8%，占儿科癌症相关死亡的15%。最近的测序和转录组学研究表明RAS-MAPK通路在神经母细胞瘤的发生和发展中的作用。这篇综述汇集了该通路参与神经母细胞瘤的最新证据。我们讨论RAS-MAPK通路的一般功能，它在神经母细胞瘤中失调的临床意义，以及目前有前途的靶向参与信号传导的蛋白质的疗法。