未经证实:心力衰竭的病理生理学及其临床症状以炎症为特征。白细胞亚群水平的升高是众所周知的炎症指标,在确定心血管疾病患者的预后中起着预测作用。此外,血小板是炎症的重要介质,尤其是当它们与白细胞相互作用时。血小板合成,激活,和功能都受到心力衰竭的影响。因此,这项研究旨在确定血小板的大小,中性粒细胞,心力衰竭患者的淋巴细胞异常。
UNASSIGNED:2022年6月至7月在冈达尔大学综合专科医院进行了回顾性横断面研究。共纳入245份心力衰竭患者的医疗记录。关于社会人口统计的数据,临床,并从医疗记录中收集了一些血液学和生化参数。将数据输入Epi-Data4.6.0.2,然后导出到Stata11.0统计软件进行分析。计算二元逻辑回归分析及其比值比,以确定与结果变量相关的因素。P值<0.05被认为具有统计学意义。
未经证实:成人心力衰竭患者中最常见的白细胞异常是嗜中性粒细胞增多症,在17.55%(95%CI:13.26-22.87)中检测到。此外,在10.20%(95%CI:6.97-14.70)的患者中观察到淋巴细胞增多.心力衰竭患者血小板减少和血小板增多的程度分别为12.24%(95%CI:8.67-17.01%)和2.86%(95%CI:1.36-5.90%),分别。仅女性与心力衰竭患者的中性粒细胞增多显著相关(AOR=2.33;95%CI:1.05-5.16)。然而,没有一个变量与血小板和淋巴细胞异常显著相关.
未经批准:嗜中性粒细胞,淋巴细胞增多,血小板减少是心力衰竭患者常见的白细胞和血小板异常。因此,早期发现和处理这些异常的根本原因对于改善患者预后和预防进一步的并发症可能很重要.
UNASSIGNED: Heart failure pathophysiology and its clinical symptoms are characterized by inflammation. Elevated levels of leukocyte subpopulations are a well-known indicator of inflammation and play a predictive role in determining the prognosis of patients with cardiovascular diseases. Besides, platelets are essential mediators of inflammation, especially when they interact with leukocytes. Platelet synthesis, activation, and function are all impacted by heart failure. Thus, the
study was aimed at determining the magnitude of platelet, neutrophil, and lymphocyte abnormalities in patients with heart failure.
UNASSIGNED: A retrospective cross-sectional
study was conducted from June to July 2022 at the University of Gondar comprehensive specialized hospital. A total of 245 medical records of heart failure patients were included. Data regarding socio-demographic, clinical, and some hematological and biochemical parameters were collected from medical records. Data was entered into Epi-Data 4.6.0.2 and then exported to Stata 11.0 statistical software for analysis. A binary logistic regression analysis with its odds ratio was calculated to identify factors associated with the outcome variables. P-value <0.05 was considered statistically significant.
UNASSIGNED: The most frequent leukocyte abnormality among adults with heart failure was neutrophilia, which was detected in 17.55% (95% CI: 13.26-22.87). Besides,
lymphocytosis was observed in 10.20% (95% CI: 6.97-14.70) of patients. The magnitude of thrombocytopenia and thrombocytosis among patients with heart failure was 12.24% (95% CI: 8.67-17.01%) and 2.86% (95% CI: 1.36-5.90%), respectively. Only being female was significantly associated with neutrophilia in patients with heart failure (AOR = 2.33; 95% CI: 1.05-5.16). However, none of the variables were significantly associated with platelet and lymphocyte abnormalities.
UNASSIGNED: Neutrophilia,
lymphocytosis, and thrombocytopenia are the common leukocyte and platelet abnormalities in heart failure patients. Therefore, early detection and management of the underlying causes of those abnormalities may be important to improve patients\' outcomes and prevent further complications.