Lubrication

润滑
  • 文章类型: Journal Article
    背景:窥器润滑可能有助于减轻巴氏涂片采集期间的疼痛,从而增加宫颈癌筛查和重复检测的摄取,但人们担心它会干扰细胞学结果。
    目的:确定并比较宫颈细胞学涂片的充分性和接受宫颈癌筛查的妇女有无镜润滑的平均疼痛评分。
    方法:这是一项在尼日利亚一家三级医院接受宫颈癌筛查的132名妇女的随机对照研究。66名参与者被随机分配到“凝胶”和“无凝胶”组,分别。用润滑窥器(\'凝胶组\')或非润滑窥器(\'无凝胶组\')从每个参与者收集巴氏涂片。主要结局指标是宫颈细胞学涂片不满意的女性比例和平均数字评分疼痛量表。而次要结局指标是愿意进行重复检测的女性比例和巴氏涂片检查结果的细胞学诊断.
    结果:两组的基线社会人口统计学变量相似。两组宫颈涂片结果不满意的比例无显著差异(13.6%vs.21.2%,p=0.359)。然而,凝胶组的平均疼痛评分明显低于无凝胶组(45.04vs.87.96;p<0.001)。每组参与者的比例相等(90.9%vs.90.9%;p>0.999)愿意在未来重复宫颈涂片检查。
    结论:窥器润滑不影响宫颈涂片的充分性,但显著减轻了子宫颈抹片采集过程中的疼痛。此外,这并没有显着影响将来再次进行宫颈涂片检查的意愿。
    背景:该试验已在泛非临床试验注册中心注册,其唯一标识号为:PACTR2020077533364675。
    BACKGROUND: Speculum lubrication may help to reduce the pain experienced during Pap-smear collection and hence increase uptake of cervical cancer screening and repeat testing, but there are fears of its interference with cytological results.
    OBJECTIVE: To determine and compare the adequacy of cervical cytology smears and the mean pain scores of women undergoing cervical cancer screening with or without speculum lubrication.
    METHODS: This was a randomised controlled study of 132 women having cervical cancer screening at a tertiary hospital in Nigeria. Sixty-six participants were randomly assigned to the \'Gel\' and \'No Gel\' groups, respectively. Pap smears were collected from each participant with a lubricated speculum (\'Gel group\') or a non-lubricated speculum (\'No Gel group\'). The primary outcome measures were the proportion of women with unsatisfactory cervical cytology smears and the mean numeric rating scale pain scores, while the secondary outcome measures were the proportion of women who were willing to come for repeat testing and the cytological diagnosis of Pap-smear results.
    RESULTS: The baseline socio-demographic variables were similar in both groups. There was no significant difference in the proportion of unsatisfactory cervical smear results between the two groups (13.6% vs. 21.2%, p = 0.359). However, the mean pain scores were significantly lower in the gel group than in the no gel group (45.04 vs. 87.96; p<0.001). An equal proportion of the participants in each group (90.9% vs. 90.9%; p > 0.999) were willing to come for repeat cervical smears in the future.
    CONCLUSIONS: Speculum lubrication did not affect the adequacy of cervical smears but significantly reduced the pain experienced during pap smear collection. Also, it did not significantly affect the willingness to come for repeat cervical smears in the future.
    BACKGROUND: The trial was registered with the Pan-African Clinical Trial Registry with a unique identification and registration number: PACTR2020077533364675.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    具有明显收敛性的香烟会减少消费者的享受。然而,由于香烟的成分复杂,准确量化收敛性强度一直具有挑战性。为了解决这个问题,进行研究以开发一种在模拟口腔环境中评估收敛性强度的方法。采用标准感官评价方法测定了4种卷烟品牌的涩味强度。通过模拟吸烟过程制备主流烟雾吸收溶液(MS),并对其理化性质(如总酚含量和pH值)进行了分析。使用MFT-5000磨损试验机测试了五种溶液的润滑性能,并考察了影响卷烟收敛性的因素。结果表明,MS的总酚含量和pH值与收敛强度呈正相关和负相关。分别。特别是,MS的润滑性能与收敛强度显著相关,在测试过程中,相关系数受负载和速度的影响。该研究得出的结论是,与MS的总酚含量和pH值相比,摩擦系数是评估卷烟收敛程度的更可靠指标,为高档卷烟的收敛性评估和开发提供新的见解。
    Cigarettes with pronounced astringency can diminish consumers\' enjoyment. However, due to the complex composition of cigarettes, quantifying astringency intensity accurately has been challenging. To address this, research was conducted to develop a method for assessing astringency intensity in a simulated oral environment. The astringency intensity of four cigarette brands was determined using the standard sensory evaluation method. The mainstream smoke absorbing solution (MS) was prepared by simulating the cigarette smoking process, and its physicochemical properties (such as total phenol content and pH levels) were analyzed. The lubrication properties of the five solutions were tested using the MFT-5000 wear tester, and factors influencing cigarette astringency were examined. The findings showed that total phenol content and pH of MS were positively and negatively correlated with astringency intensity, respectively. Particularly, the lubrication properties of MS were significantly correlated with astringency intensity, and the correlation coefficient was affected by load and speed during testing. The study concluded that coefficient of friction was a more reliable measure for assessing the extent of astringency in cigarettes than the total phenol content and pH of MS, offering new insights into astringency evaluation and development of high-grade cigarettes.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    这项研究调查了流变学,形态学,和包含0.25、0.5和1wt。的熔融加工聚乳酸/乙烯醇(70PLA/30EVOH)共混复合材料的机械性能。%的氧化石墨烯(GO)纳米片。基于热力学的提出了纳米粒子在EVOH中的定位,SEM研究表明,在共混物中引入GO增加了分散液滴的尺寸,这归因于GO在EVOH内的本地化,如TEM所证实。流变学结果表明,含有0.25wt。与纯混合物相比,GO的百分比,这归因于添加的GO纳米片的滑动效应。然而,含有较高量的GO纳米片的样品比纯共混物表现出更优异的弹性。弹性的增加暗示性地归因于流体动力学相互作用的优势,添加纳米血小板的物理网络,和聚合物/GO相互作用超过GO纳米片在较高负载下的滑动作用。此外,研究了混合顺序的影响,与纯混合物相比,PLA和GO的预混合表现出液滴半径的减小。这归因于GO纳米片在PLA和界面中的定位,流变结果和机械评估证实了这一点。
    This study investigates the rheological, morphological, and mechanical properties of melt-processed polylactide/ethylene vinyl alcohol (70PLA/30EVOH) blend composites containing 0.25, 0.5, and 1 wt.% of graphene oxide (GO) nanoplates. Thermodynamic-based suggested the localization of nanoparticles in EVOH, SEM studies showed that the introduction of GO to the blend increased dispersed droplet size, which was attributed to the localization of GO within EVOH, as confirmed by TEM. The rheology results indicated a decrease in the elasticity for the composite containing 0.25 wt.% of GO compared to the neat blend, which was attributed to the sliding effect of the added GO nanoplatelets. However, samples containing higher amounts of GO nanoplatelets exhibited more excellent elasticity than the neat blend. The increased elasticity was suggestively attributed to the dominance of hydrodynamic interactions, the physical network of added nanoplatelets, and polymer/GO interactions over the sliding role of the GO nanoplatelets at higher loadings. In addition, the effect of the order of mixing was investigated, and the premixing of PLA and GO exhibited a decrease in the droplet radius compared to the neat blend. It was ascribed to the localization of GO nanosheets in the PLA and interface, which was confirmed by rheological results and mechanical assessments.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    在生物医学设备上进行润滑涂层的表面改性是提高整体性能和临床疗效的关键策略。显着减少设备与人体组织之间的摩擦,并减轻介入和长期植入过程中的组织损伤。最近,各种亲水性聚合物材料已用于实现表面官能化,赋予生物医学装置优异的超润滑性能。N-乙烯基吡咯烷酮(NVP)和2-甲基丙烯酰氧基乙基磷酰胆碱(MPC)是非离子和两性离子材料的两种典型代表。然而,它们之间的润滑机理和性能的比较研究仍然存在研究空白。在这项研究中,生物启发和多巴胺辅助共沉积技术被用来制造仿生亲水涂层,包括P(DMA-NVP)和P(DMA-MPC),在聚氨酯上。为了对自粘涂层性能进行彻底的比较分析,合成了3M比例的共聚物并进行了综合材料评价。此外,表面形态,亲水性,在微观尺度和宏观尺度进行润滑。发现两种亲水涂层均表现出良好的稳定性。P(DMA-MPC)涂层,由于吸引和结合大量水分子的能力,与P(DMA-NVP)涂层相比,具有优异的润滑效果。该研究提供了对自粘涂层的润滑行为的深入了解,以增强其在生物医学工程中的功能和应用。
    Surface modification of lubricating coatings on biomedical devices is a pivotal strategy to improve the overall performance and clinical efficacy, significantly reducing friction between devices and human tissues and mitigating tissue damage during intervention and long-term implantation. Recently, various hydrophilic polymeric materials have been used for achieving surface functionalization, endowing the biomedical device with excellent superlubrication performance. N-Vinylpyrrolidone (NVP) and 2-methacryloyloxyethyl phosphorylcholine (MPC) are two typical representatives of nonionic and zwitterionic materials. However, there is still a research gap in a comparative study of the lubrication mechanisms and properties between them. In this study, a bioinspired and dopamine-assisted codeposition technique was used to fabricate biomimetic hydrophilic coatings, including P(DMA-NVP) and P(DMA-MPC), on polyurethane. To achieve a thorough comparative analysis of the self-adhesive coating performance, 3 M ratios of the copolymers were synthesized and comprehensive material evaluations were conducted. Additionally, surface morphology, hydrophilicity, and lubrication at both the microscale and macroscale were performed. It was found that both hydrophilic coatings exhibited good stability. The P(DMA-MPC) coating, due to the ability to attract and bind a large number of water molecules, demonstrated superior lubrication effects compared to the P(DMA-NVP) coating. The study provides an in-depth understanding of the lubrication behavior of the self-adhesive coatings to enhance the functionality and application in biomedical engineering.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    选择性5-羟色胺再摄取抑制剂(SSRIs)是精神药理学的基石。然而,它们会引起副作用,如性功能障碍,导致停止治疗。我们旨在研究因SSRIs而不是氟西汀引起的性功能障碍的女性的药物假期的有效性和安全性。这项研究是一项为期8周的随机研究,开放标签,对照试验包括年龄在18至50岁之间、在接受SSRIs治疗时出现性功能障碍的已婚妇女。干预组实施药物假期,星期四和星期五不服药,对照组继续常规用药。采用女性性功能指数(FSFI)和28题一般健康问卷(GHQ-28)评估性功能和心理健康,分别。共有50名参与者完成了试验。药物假期组表现出觉醒的显著改善(p<0.001),欲望(p=0.001),性高潮(p<0.001),满意度(p<0.001),润滑(p=0.021),和整体性健康(p<0.001)。疼痛组间差异显著(p<0.001),尽管没有显著的组内变化。两组的心理健康都得到了改善,尽管组间无显著差异。没有报告重大不良反应。药物假期在八周的时间范围内没有立即引起安全问题或重大不良反应,这表明它可能是管理SSRI引起的女性性功能障碍的安全有效的策略,同时改善心理健康。需要进一步的研究才能得出明确的结论。
    Selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of psychopharmacology. However, they cause side effects such as sexual dysfunction, leading to the discontinuation of treatment. We aimed to investigate the efficacy and safety of drug holidays for women experiencing sexual dysfunction Induced by SSRIs other than fluoxetine. This study was an 8-week randomized, open-label, controlled trial including married women aged between 18 and 50 years who had experienced sexual dysfunction while undergoing treatment with SSRIs. The intervention group implemented drug holidays by not taking medications on Thursdays and Fridays, while the control group continued regular medication use. The female sexual function index (FSFI) and the 28-question general health questionnaire (GHQ-28) were administered to assess sexual function and mental health, respectively. A total of 50 participants completed the trial. The drug holidays\' group showed significant improvements in arousal (p < 0.001), desire (p = 0.001), orgasm (p < 0.001), satisfaction (p < 0.001), lubrication (p = 0.021), and overall sexual health (p < 0.001). The between-group difference of pain was significant (p < 0.001), despite no significant within-group change. Mental health improved in both groups, despite no significant between-group difference. No major adverse effects were reported. Drug holidays did not introduce immediate safety concerns or significant adverse effects during the timeframe of eight weeks, suggesting that it may be a safe and effective strategy for managing SSRI-induced sexual dysfunction in women, alongside improving mental health. Further research is needed to reach a definitive conclusion.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:纤维肌痛综合征(FMS)是一种风湿性疾病,已观察到影响性欲的自我感知。
    目的:该研究旨在评估性功能障碍(SD),与SD水平建立可能的关联,并评估与健康对照女性相比,西班牙FMS女性的体力活动(PA)水平对SD的影响。
    方法:本研究是横断面的。共有170名妇女自愿同意在2019年9月至2020年2月期间参加:FMS组88名,对照组82名。
    结果:主要结局指标为SD,通过女性性功能指数(FSFI)评估,和PA水平,通过结构化面试进行评估。
    结果:FMS组和对照组在每个领域和总SD评分方面存在显着差异(P<0.05)。此外,在探索FMS与SD风险之间的关联时,我们获得了中度显着的直接关联(χ2[1]=37.071,P<.05,phi=0.467)。结果表明,当PA水平未达到期望时,FMS组与对照组之间存在统计学差异。疼痛,和FSFI总分(P<0.05)。当达到PA水平时,在所有领域都发现了组间差异,以及FSFI的总分(P<0.05)。
    结论:应评估FMS女性的性功能,而未来的治疗应该针对这一临床领域,目的是在这一人群中管理SD。
    主要限制是结果测量是自我报告的。
    结论:我们发现西班牙女性FMS的SD患病率很高,对欲望等方面的影响,唤醒,润滑,性高潮,满意,性交时的疼痛。此外,FMS和SD之间存在中度直接关联。最终,结果表明,不管PA,FMS女性报告SD增加。
    Fibromyalgia syndrome (FMS) is a rheumatic disorder that has been observed to affect self-perception of sexuality.
    The study aims to assess sexual dysfunction (SD), establish possible associations with SD levels, and evaluate the impact of physical activity (PA) levels on SD in Spanish women with FMS as compared with healthy control women.
    The study was cross-sectional. A total of 170 women voluntarily agreed to participate between September 2019 and February 2020: 88 in the FMS group and 82 in the control group.
    The main outcome measures were SD, as assessed through the Female Sexual Function Index (FSFI), and PA levels, as assessed with a structured interview.
    There were significant differences in every domain and total SD score between the FMS and control groups (P < .05). In addition, we obtained a moderate significant direct association (χ2[1] = 37.071, P < .05, phi = 0.467) when exploring the associations between FMS and risk of SD. Results showed statistically significant differences between the FMS group and the control group when PA levels were not reached in the desire, pain, and total scores of the FSFI (P < .05). When the PA levels were reached, between-group differences were found in all domains, as well as in the total score of the FSFI (P < .05).
    Sexual function should be evaluated in women with FMS, while future treatments should address this clinical area with the aim of managing SD in this population.
    The main limitation is that the outcome measures were self-reported.
    We found a high prevalence of SD in Spanish women with FMS, with an impact on aspects such as desire, arousal, lubrication, orgasm, satisfaction, and pain during sexual intercourse. In addition, there is a moderate direct association between FMS and SD. Ultimately, the results showed that, irrespective of PA, women with FMS reported increased SD.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    背景:生殖器肯定手术(GAS)的需求一直在增加。黄金标准是阴茎皮肤倒置,使用皮肤移植创造新阴道。目的是在物理和功能上实现最现实的结果。不同的研究结果相互矛盾,润滑的使用不够清楚,而乙状结肠成形术的使用已被捍卫为持续润滑。
    目的:我们的目的是通过阴茎皮肤倒置评估变性女性阴道成形术后的性功能和润滑。
    方法:我们对45例原发性阴茎内翻阴道成形术患者进行了前瞻性研究。参与者在后续咨询中回答了两份问卷:女性性功能指数(FSFI)和18项自定义问卷。
    结果:我们患者的平均FSFI评分为28.9,达到定义性障碍的临界值。与Wylomanski对照组相比,FSFI评分和各亚组中无差异.考虑到润滑,69%的患者对他们的润滑感到满意或非常满意。此外,53%报告每次性高潮时液体释放。
    结论:这项研究报告了对性欲和润滑的高满意度,针对阴茎倒置的气体,在术后润滑方面声誉不佳。首次描述了喷射效应,并且在53%的患者中存在喷射效应。
    Genital affirmation surgery (GAS) requests are consistently increasing in demand. The gold standard is penile skin inversion, using cutaneous grafting for neovagina creation. The aim is to achieve the most realistic results both physically and functionally. Different studies have contradictory results, and the use of lubrication is insufficiently clear, while the use of sigmoidoplasty has been defended for constant lubrication.
    Our aim was to evaluate transgender women\'s sexual function and lubrication after vaginoplasty by penile skin inversion.
    We performed a prospective study on 45 patients who underwent primary penile inversion vaginoplasty. Participants answered two questionnaires during the follow-up consultation: the Female Sexual Function Index (FSFI) and an 18-item custom questionnaire.
    The average FSFI score of our patients was 28.9, up to the cut-off defining a sexual disorder. Compared to the Wylomanski control group, no differences were found for the FSFI score and in the subgroups. Considering lubrication, 69% of the patients were satisfied or very satisfied with their lubrication. Furthermore, 53% reported a fluid release at each orgasm.
    This study reported high satisfaction for both sexuality and lubrication, proning against penile inversion\'s GAS bad reputation concerning postoperative lubrication. A squirting effect was described for the first time and was present in 53% of our transpatients.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    目的和目的这项体外研究的目的是通过正畸金属托槽和不锈钢(SS)弓丝之间的滑动力学来评估和比较各种漱口剂对摩擦阻力的影响。材料和方法每组包括15个上颌第一前磨牙预调整边缘可移动SS样本,未粘合支架(KodenInc.,美国)用动力臂焊接,其中100克负载被悬挂。支架用弹性元件连接(KodenInc.,美国)与0.019“x0.025”SS弓丝一起在有机玻璃板上(经典正畸学,美国),并从Instron机器的上部组件上悬挂下来。在干燥条件下测试摩擦系数(对照),人工唾液(AS)(湿口,ICPA健康产品有限公司印度),0.2%葡萄糖酸氯己定(CHG)漱口水(Hexidine,ICPA健康产品有限公司印度),0.05%氟化钠(NaF)漱口水(ACT抗腔氟化物漱口水,赛诺菲公司,美国),木炭(CC)漱口水(Hello活性炭额外的新鲜漱口水,HelloProductsLLC,美国)和注入臭氧的椰子油(O3)提油溶液(O3Essentials,健康游侠商店,美国)。为了计算摩擦系数,在以5mm/min的十字头速度移动的同时将50L添加到测试样品中。使用单向方差分析(ANOVA)比较各组,和Tukey的事后分析进行多次成对比较。结果对照组摩擦系数平均值最高(2.01),其次是AS(1.79),和最小的O3(1.15)。几乎所有组的漱口剂均观察到统计学上的显着差异,但NaF对CHG和CC有重要意义。然而,CHG与CC没有任何显著差异。结论在金属托槽和不锈钢弓丝之间的滑动力学过程中,注入臭氧的椰子油拉油溶液观察到较低的摩擦系数。几乎所有的口腔清洗剂都显示出明显不同的摩擦系数值。
    Aim and objectives The aim of this in-vitro study is to evaluate and compare the effect of various mouth rinsing agents on frictional resistance through sliding mechanics among orthodontic metal brackets and stainless steel (SS) archwire. Materials and methods Each group comprised 15 samples of maxillary first premolar pre-adjusted edgewise SS movable, un-bonded brackets (Koden Inc., United States) which were welded with a power arm, where 100 g of the load was suspended. Brackets were ligated with elastic modules (Koden Inc., United States) onto the perspex sheet along with 0.019\" x 0.025\" SS archwire (Classic Orthodontics, United States) and were suspended from the upper component of the Instron machine. The coefficient of friction was tested in dry conditions (control), artificial saliva (AS) (Wet Mouth, ICPA Health Product Ltd., India), 0.2% chlorhexidine gluconate (CHG) mouthwash (Hexidine, ICPA Health Product Ltd., India), 0.05% sodium fluoride (NaF) mouthwash (ACT Anti-Cavity Fluoride Mouthwash, Sanofi Company, United States), charcoal (CC) mouthwash (Hello Activated Charcoal Extra Freshening Mouthwash, Hello Products LLC, United States) and ozone-infused oil-pulling solution with coconut oil (O3) (O3 Essentials, Health Ranger Store, United States). In order to calculate the coefficient of friction, 50 L was added to the test sample while moving at a 5 mm/min crosshead speed. The groups were compared using the one-way analysis of variance (ANOVA), and Tukey\'s post hoc analysis was performed for multiple pairwise comparisons. Results The coefficient of friction with the highest mean values was observed with the control group (2.01), followed by AS (1.79), and the least with O3 (1.15). Statistically significant differences were observed with almost all groups of mouth rinsing agents, but NaF is significant with CHG and CC. However, CHG did not have any significant difference from CC. Conclusions Lower coefficient of frictional values were observed with the ozone-infused oil-pulling solution with coconut oil during sliding mechanics between metal brackets and stainless steel archwire. Almost all the mouth rinsing agents showed a significantly different coefficient of friction value.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    离子液体与石墨烯添加剂的结合在高性能润滑材料领域得到了广泛的关注。然而,石墨烯影响ILs承载和抗磨损能力的模糊机理有待进一步研究。在这项工作中,摩擦模拟表明,添加石墨烯导致摩擦系数降低高达88%,与纯IL相比,但由于石墨烯在高应力下的破坏,润滑性能丧失。同时,与单层结构相比,多层石墨烯具有更好的减摩性能和摩擦耐久性,这归因于多层石墨烯结构中的易剪切性质和高拉伸应力位点百分比的减少。此外,研究发现,过厚的ILs膜会与石墨烯形成三体磨料磨损结构,这加速了石墨烯的结构破坏,并导致其摩擦学性能下降。相信这些发现对于设计用于实际工程的高性能润滑油具有一定的参考价值。
    Ionic liquid (IL) combined with graphene additives have garnered extensive attention in the field of high-performance lubricating materials. However, the ambiguous mechanism of graphene influencing the load-carrying and anti-wear capacity of ILs needs further study. In this work, friction simulation shows that adding graphene causes friction coefficient to reduce by up to 88% compared with pure ILs, but lubrication performance is lost due to the destruction of graphene under high stress. Meanwhile, multilayer graphene has better friction-reducing performance and friction durability as compared to the monolayer structure, which is attributed to the easy-shear property and the reduction in the percentage of high tensile stress sites in multilayer graphene structure. In addition, it was found that excessively thick ILs film would form a three-body abrasive wear structure with graphene, which accelerated the structural destruction of graphene and caused a decline in its tribological properties. It is believed these findings can be valuable for designing of high-performance lubricating oil for practical engineering.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    目标:粘贴是片剂制造过程中最常见和最具破坏性的问题之一。粘附是在压缩期间粉末粘附到工具表面上。由于它的发生涉及众多因素,了解片剂粘附需要同时研究这些因素,以阐明它们可能的相互作用。然而,通过实验进行这样的研究可能会带来巨大的财务和技术负担。在这项研究中,我们的目标是利用工业制造过程中通常产生的大量数据来获得对粘附的见解。方法:这是通过收集和分析总共71个使用基于布洛芬的制剂的历史批次来实现的。我们将每个批次与一百个参数相关联,包括一个定性的粘滞描述符,并采用主要基于多变量数据分析的预定义方法。结果和结论:我们的结果强调了润滑的作用,含水量,低熔点布洛芬的粘附倾向。基于这些发现,我们提出并讨论了一种工业制造数据分析方法及其相关的系统方法论,由收集组成,探索,和数据建模。
    UNASSIGNED: Sticking is one of the most common and damaging issues that occur during tablet manufacturing. Sticking is the adhesion of powder onto tooling surfaces during compression. Because of the numerous factors involved in its occurrence, understanding tablet sticking requires the simultaneous investigation of these factors to clarify their possible interactions. However, conducting such a study experimentally can present a significant financial and technical burden. In this study, we aimed to leverage the large amount of data that is usually generated during industrial manufacturing to gain insights into sticking.
    UNASSIGNED: This was achieved by collecting and analyzing a total of 71 historical batches that used an ibuprofen-based formulation. We associate each batch with a hundred parameters, including a qualitative descriptor of sticking, and employ a predefined methodology based primarily on multivariate data analysis.
    UNASSIGNED: Our results highlight the role of lubrication, water content, and the low melting point of ibuprofen in its sticking tendency. Based on these findings, we propose and discuss an industrial manufacturing data analysis approach to sticking and its associated systematic methodology, consisting of collection, exploration, and data modeling.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

公众号