Abstract:
Surface modification of lubricating coatings on biomedical devices is a pivotal strategy to improve the overall performance and clinical efficacy, significantly reducing friction between devices and human tissues and mitigating tissue damage during intervention and long-term implantation. Recently, various hydrophilic polymeric materials have been used for achieving surface functionalization, endowing the biomedical device with excellent superlubrication performance. N-Vinylpyrrolidone (NVP) and 2-methacryloyloxyethyl phosphorylcholine (MPC) are two typical representatives of nonionic and zwitterionic materials. However, there is still a research gap in a comparative study of the lubrication mechanisms and properties between them. In this study, a bioinspired and dopamine-assisted codeposition technique was used to fabricate biomimetic hydrophilic coatings, including P(DMA-NVP) and P(DMA-MPC), on polyurethane. To achieve a thorough comparative analysis of the self-adhesive coating performance, 3 M ratios of the copolymers were synthesized and comprehensive material evaluations were conducted. Additionally, surface morphology, hydrophilicity, and lubrication at both the microscale and macroscale were performed. It was found that both hydrophilic coatings exhibited good stability. The P(DMA-MPC) coating, due to the ability to attract and bind a large number of water molecules, demonstrated superior lubrication effects compared to the P(DMA-NVP) coating. The study provides an in-depth understanding of the lubrication behavior of the self-adhesive coatings to enhance the functionality and application in biomedical engineering.
摘要:
在生物医学设备上进行润滑涂层的表面改性是提高整体性能和临床疗效的关键策略。显着减少设备与人体组织之间的摩擦,并减轻介入和长期植入过程中的组织损伤。最近,各种亲水性聚合物材料已用于实现表面官能化,赋予生物医学装置优异的超润滑性能。N-乙烯基吡咯烷酮(NVP)和2-甲基丙烯酰氧基乙基磷酰胆碱(MPC)是非离子和两性离子材料的两种典型代表。然而,它们之间的润滑机理和性能的比较研究仍然存在研究空白。在这项研究中,生物启发和多巴胺辅助共沉积技术被用来制造仿生亲水涂层,包括P(DMA-NVP)和P(DMA-MPC),在聚氨酯上。为了对自粘涂层性能进行彻底的比较分析,合成了3M比例的共聚物并进行了综合材料评价。此外,表面形态,亲水性,在微观尺度和宏观尺度进行润滑。发现两种亲水涂层均表现出良好的稳定性。P(DMA-MPC)涂层,由于吸引和结合大量水分子的能力,与P(DMA-NVP)涂层相比,具有优异的润滑效果。该研究提供了对自粘涂层的润滑行为的深入了解,以增强其在生物医学工程中的功能和应用。