■肝脏硬度测量可用于评估肝纤维化,并且可以通过使用FibroScan®和声辐射力脉冲成像的瞬时弹性成像来获得。该研究旨在在慢性丙型肝炎队列中使用FibroScan®和声辐射力脉冲建立肝脏硬度测量评分,并探讨评分与影响因素之间的相关性和一致性。
■患者使用FibroScan®(肝脏右叶)和声辐射力脉冲(肝脏右叶和左叶)进行肝脏硬度测量。我们使用Spearman的相关性来探索FibroScan®与声辐射力冲动评分之间的关系。使用Bland-Altman图来评估FibroScan®和声辐射力脉冲评分的平均百分比差异之间的偏差。单变量和多变量分析用于评估体重指数、年龄和性别影响肝脏硬度测量之间的一致性。
■Bland-Altman显示FibroScan®和声辐射力脉冲评分之间的平均(95%CI)百分比差异为27.5%(17.8,37.2),p<0.001。FibroScan®和声辐射力脉冲评分的平均差异和百分比差异之间存在负相关(r(95%CI)=-0.41(-0.57,-0.21),p<0.001),因此表明,对于更大的FibroScan®和声辐射力脉冲评分,百分比差异变得更小。体重指数是FibroScan®和声辐射力脉冲之间差异的最大影响因素(r=0.12(0.01,0.23),p=0.05)。5/8段和左叶的声辐射力脉冲评分显示出良好的相关性(r(95%CI)=0.83(0.75,0.89),p<0.001)。
■FibroScan®和声辐射力脉冲对慢性丙型肝炎感染患者肝硬度的评估具有相似的预测值;然而,协议的水平在较低和较高的分数不同。
UNASSIGNED: Liver stiffness measurements can be used to assess liver fibrosis and can be acquired by transient elastography using FibroScan® and with Acoustic Radiation Force Impulse imaging. The
study aimed to establish liver stiffness measurement scores using FibroScan® and Acoustic Radiation Force Impulse in a chronic hepatitis C cohort and to explore the correlation and agreement between the scores and the factors influencing agreement.
UNASSIGNED: Patients had liver stiffness measurements acquired with FibroScan® (right lobe of liver) and Acoustic Radiation Force Impulse (right and left lobe of liver). We used Spearman\'s correlation to explore the relationship between FibroScan® and Acoustic Radiation Force Impulse scores. A Bland-Altman plot was used to evaluate bias between the mean percentage differences of FibroScan® and Acoustic Radiation Force Impulse scores. Univariable and multivariable analyses were used to assess how factors such as body mass index, age and gender influenced the agreement between liver stiffness measurements.
UNASSIGNED: Bland-Altman showed the average (95% CI) percentage difference between FibroScan® and Acoustic Radiation Force Impulse scores was 27.5% (17.8, 37.2), p < 0.001. There was a negative correlation between the average and percentage difference of the FibroScan® and Acoustic Radiation Force Impulse scores ( r (95% CI) = -0.41 (-0.57, -0.21), p < 0.001), thus showing that percentage difference gets smaller for greater FibroScan® and Acoustic Radiation Force Impulse scores. Body mass index was the biggest influencing factor on differences between FibroScan® and Acoustic Radiation Force Impulse (r = 0.12 (0.01, 0.23), p = 0.05). Acoustic Radiation Force Impulse scores at segment 5/8 and the left lobe showed good correlation (r (95% CI) = 0.83 (0.75, 0.89), p < 0.001).
UNASSIGNED: FibroScan® and Acoustic Radiation Force Impulse had similar predictive values for the assessment of liver stiffness in patients with chronic hepatitis C infection; however, the level of agreement varied across lower and higher scores.