Abstract：
To explore the clinical application of shear wave elastography (SWE) in evaluating the degree of liver fibrosis in children.
To explore the value of SWE in assessing liver fibrosis in children, the correlation between elastography values and the METAVIR grade of liver fibrosis in children with biliary system or liver diseases was studied. Children with significant liver enlargement were enrolled, and the fibrosis grade was analyzed to explore the value of SWE in assessing the degree of liver fibrosis in the presence of significant liver enlargement.
A total of 160 children with bile system or liver diseases were recruited. The areas under the receiver operating characteristic curve (AUROCs) for liver biopsy from stage F1 to F4 were 0.990, 0.923, 0.819, and 0.884. According to the degree of liver fibrosis at liver biopsy, there was a high correlation between the SWE value and the degree of liver fibrosis (correlation coefficient 0.74). There was no significant correlation between the Young\'s modulus value of the liver and the degree of liver fibrosis (correlation coefficient 0.16).
Supersonic SWE can generally accurately evaluate the degree of liver fibrosis in children with liver disease. However, When the liver is significantly enlarged, SWE can only evaluate liver stiffness based on Young\'s modulus values, and the degree of liver fibrosis must still be determined by pathologic biopsy.
To explore the value of SWE in assessing liver fibrosis in children, the correlation between elastography values and the METAVIR grade of liver fibrosis in children with biliary system or liver diseases was studied. Children with significant liver enlargement were enrolled, and the fibrosis grade was analyzed to explore the value of SWE in assessing the degree of liver fibrosis in the presence of significant liver enlargement.
A total of 160 children with bile system or liver diseases were recruited. The areas under the receiver operating characteristic curve (AUROCs) for liver biopsy from stage F1 to F4 were 0.990, 0.923, 0.819, and 0.884. According to the degree of liver fibrosis at liver biopsy, there was a high correlation between the SWE value and the degree of liver fibrosis (correlation coefficient 0.74). There was no significant correlation between the Young\'s modulus value of the liver and the degree of liver fibrosis (correlation coefficient 0.16).
Supersonic SWE can generally accurately evaluate the degree of liver fibrosis in children with liver disease. However, When the liver is significantly enlarged, SWE can only evaluate liver stiffness based on Young\'s modulus values, and the degree of liver fibrosis must still be determined by pathologic biopsy.
摘要：
目的：探讨剪切波弹性成像（SWE）评估儿童肝纤维化程度的临床应用。
方法：为了探讨SWE在评估儿童肝纤维化中的价值，研究了胆道系统或肝脏疾病患儿的弹性成像值与肝纤维化的METAVIR分级之间的相关性。有显著肝脏肿大的儿童被纳入研究，并对纤维化分级进行分析,以探讨SWE在评估肝纤维化程度时的价值。
结果：共招募了160名患有胆汁系统或肝脏疾病的儿童。从F1期到F4期肝活检的受试者工作特征曲线（AUROC）下面积分别为0.990、0.923、0.819和0.884。根据肝活检时的肝纤维化程度，SWE值与肝纤维化程度高度相关(相关系数0.74)。肝脏杨氏模量值与肝纤维化程度无显著相关性(相关系数0.16)。
结论：SupersonicSWE通常可以准确评估肝病患儿的肝纤维化程度。然而,当肝脏明显增大时，SWE只能根据杨氏模量值评估肝脏硬度，肝纤维化程度仍需通过病理活检来确定。
方法：为了探讨SWE在评估儿童肝纤维化中的价值，
结果：共招募了160名患有胆汁系统或肝脏疾病的儿童。
结论：SupersonicSWE通常可以准确评估肝病患儿的肝纤维化程度。
